A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: Clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity

Lassi, Zohra S; Ana, Ali; Das, Jai K; Padhani, Zahra Ali; Irfan, Omer; Bhutta, Zulfiqar A

doi:10.7189/jogh.11.05018

Cited by 101 publications

(124 citation statements)

References 54 publications

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“…The current study revealed that severity of the infection and parity were significantly associated with the adverse obstetric and neonatal outcomes of COVID-19. This study confirmed that pregnant women with moderate to severe infection were more likely to be older by approximately 3 to 4 years than those with asymptomatic or having mild symptoms of the disease 23 , 36 . Moreover, our study reported a significant association between parity (being multigravida) and developing adverse obstetric outcomes of COVID-19, which confirms Samadi et al .…”

Section: Discussionsupporting

confidence: 77%

“…This is consistent with the evidence which declared a significant association between severe form of COVID-19 in pregnancy and iatrogenic preterm delivery (75.0%); particularly in the third trimester 22 . Likewise, a systematic review included 31,016 pregnant women from 62 studies supported our findings showing around two folds increase in preterm labor and low birth weight among pregnancies with severe COVID-19 symptoms compared to control 23 . These consequences can be related to the maternal pneumonia during the COVID-19 course, which is the main contributing factor of pregnancy complications including preterm labor, placental abruption and possible maternal or fetal death 24 .…”

Section: Discussionsupporting

confidence: 74%

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Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Dileep¹,

ZainAlAbdin

AbuRuz

2022

Sci Rep

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Pregnant women with COVID-19 require special attention and care, since the infection does not only affect the mother, but also her neonate and adversely affects pregnancy outcomes. The main goal of this retrospective cohort study is to investigate association between the maternal COVID-19 severity and risk of developing adverse neonatal outcomes. Patients were stratified into asymptomatic/mild and moderate to severe COVID-19. The following neonatal outcomes were assessed: gestational age at the time of delivery, birth weight, neonatal infection, neonatal intensive care unit (NICU) admission. The average age of patients was 28.5 ± 1.4 years old and majority were multigravida (74.0%, n = 148). Of total 200 pregnant women with COVID-19, 26.5% (n = 53) had moderate/severe disease and presented with higher incidence of preterm delivery and low birth weight (88.7%, n = 47; p < 0.001). In addition, more than half of the newborns delivered by mothers with severe disease were infected by SARS-COV-2 (58.5%, n = 31) and majority were admitted to the NICU (95.0%, n = 52). Based on the multivariate logistic regression analysis, pregnant women with moderate to severe COVID-19 were at much higher risk of preterm delivery, lower birth weight, neonatal infection, as well as neonatal ICU admission (p < 0.001). In addition, multigravida women were at higher risk for preterm delivery and lower birth weight (p = 0.017 and p = 0.02; respectively). Appropriate protective measures and early detection of suspected COVID-19 should be addressed for more favorable obstetric outcomes.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 74%

Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Dileep¹,

ZainAlAbdin

AbuRuz

2022

Sci Rep

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“…The importance of monitoring children involved in the problem of SARS-CoV-2 in-fection is further highlighted by the recently acquired evidence that infection of the pregnant women can have a relevant negative impact on the neonates [ 14 , 15 ]. Maternal infections during the second and the third trimester of pregnancy have been frequently found associated with an increased risk of obstetric complications leading to preterm birth, low birth weight and several neonatal diseases, including respiratory distress syndrome, hyperbilirubinemia and need for assistance in ICU [ 14 ].…”

Section: Outcome Of Covid-19-related Neurologic Complications In Pediatric Agementioning

confidence: 99%

Are we sure that the neurological impact of COVID 19 in childhood has not been underestimated?

Principi

Esposito

2021

Ital J Pediatr

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Background Presently, it is known that, even if less frequently than in adults, children can develop a severe new coronavirus disease 2019 (COVID-19). Children with the SARS-CoV-2 infection can have neurological signs and symptoms of disease more frequently than previously thought, revealing the involvement of the central nervous system, the peripheral nervous system, or both. Aim of this manuscript is to highlight the neurologic complications associated with SARS-CoV-2 among pediatric patients with COVID-19, suggesting when to monitor carefully neurologic development. Main findings Children with a severe chronic underlying disease, infants and toddlers and those who develop the so-called multisystem inflammatory syndrome (MIS-C) are those with the highest incidence of neurological complications. Fortunately, in most of the cases, neurological manifestations, mainly represented by headache and anosmia, are mild and transient and do not significantly complicate the COVID-19 course. However, in some cases, very severe clinical problems associated with relevant alterations of neuroimaging, electroencephalography, nerve conduction studies and electromyography findings can develop. Generally, almost all the children with COVID-19 and neurological manifestations till now described have made a complete recovery, although in some cases this has occurred after several weeks of treatment. Moreover, COVID-19 infection during pregnancy has been found associated with an increased risk of obstetric complications that can lead to neurological acute and long-term manifestations in neonates. Conclusions Based on data showing the neurologic impact of COVID-19 in pediatric age, we suggest monitoring neurological development a few months after healing in pediatric patients who have presented MIS-C, seizures or other neurological manifestations and in children of pregnant women with COVID-19 in order to detect overt and subtle deficits.

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“…Symptoms of fatigue may be reported more commonly in female adults and in older age groups. 24 COVID‐19 symptoms may be more severe in pregnant women 47 and pregnancy itself (and the postpartum period) is a well‐known cause of fatigue because of a host of biologic and behavioral factors. In addition, people who identify with racial or ethnic minority groups may have a baseline level of chronic fatigue that should be considered in the assessment and treatment approach.…”

Section: Pasc Fatigue Treatment Recommendationsmentioning

confidence: 99%

Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in postacute sequelae of SARS‐CoV‐2 infection (PASC) patients

Herrera

Niehaus

Whiteson

et al. 2021

PM&R

104

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A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: Clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity

Cited by 101 publications

References 54 publications

Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Are we sure that the neurological impact of COVID 19 in childhood has not been underestimated?

Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in postacute sequelae of SARS‐CoV‐2 infection (PASC) patients

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