A systematic review and meta-analysis of epidemiology of depression in people living with HIV in east Africa

Ayano, Getinet; Solomon, Melat; Abraha, Mebratu

doi:10.1186/s12888-018-1835-3

Cited by 70 publications

(68 citation statements)

References 39 publications

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“…However, to our surprise, only 13.2% of nurses in Vietnam have depression [55], as well as 24.9% of Iranian nurses working in military hospitals [56]. In addition, the Chinese nurses even seem to have higher prevalence of depression than some special populations, such as people living with HIV with 38% [57], outpatients with 27.0% [58], and Indian elderly population with 34.4% [59]. Therefore, we may conclude that Chinese nurses were at a particularly high risk of having depressive symptoms.…”

Section: Plos Onementioning

confidence: 99%

Prevalence of depressive symptoms among nurses in China: A systematic review and meta-analysis

Xie

Yan

Wang³

et al. 2020

PLoS ONE

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Background Depression is one of the most common mental disorders, profoundly impacting an individual's performance and quality of life. Due to their unique working conditions, nursing is counted among the occupational groups at high risk for developing depression. Because of the shortage of nursing resources in China, Chinese nurses suffer from heavy daily workloads more than those in many other countries. Therefore, this study aimed to evaluate the overall prevalence of depressive symptoms and analyse the potential risk factors of depressive symptoms in Chinese nurses. Methods A systematic literature search in PubMed, EMBASE, Web of Science, the Chinese BioMedical Literature Database (CBM), the China National Knowledge Infrastructure (CNKI), and the Weipu and Wanfang databases up to Dec 31st, 2019 was performed regarding the prevalence of depressive symptoms in Chinese nurses. Eligibility assessment and data extraction were performed independently by 2 researchers, and meta-analysis was used to synthesize the data. Heterogeneity was evaluated using Cochran's Q test and quantified using the I 2 statistic. To explore the potential source of heterogeneity, subgroup analyses were also performed. In addition, both funnel plot and Egger's tests were adopted to assess publication bias. Results A total of 102 studies published from 1996 to 2019 covering 22 provinces were included for further analysis. The total number of participants was 52,592, with a range of 46 to 7205 per study. The overall prevalence of depressive symptoms in Chinese nurses was 43.83% (95% CI: 40.26%-47.42%), and 31.12% (95%CI: 27.30%-35.07%) were classified as mild degrees of depressive symptoms. The prevalence of depressive symptoms may be significantly affected by region, province or municipality and department marital status. Moreover, an increasing trend in the prevalence of depressive symptoms was observed in recent years.

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Section: Plos Onementioning

confidence: 99%

Prevalence of depressive symptoms among nurses in China: A systematic review and meta-analysis

Xie

Yan

Wang³

et al. 2020

PLoS ONE

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“…A systematic review of studies from SSA found a range of 9 to 32% prevalence of probable depression [ 10 ]. A meta-analysis of studies from East Africa indicated a 38% pooled prevalence of probable depression [ 11 ]. A systematic review of studies from Ethiopia reported a 37% pooled prevalence of probable depression among PLWHA [ 12 ] which was much higher compared to the 11% pooled prevalence in the general population [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Major depressive disorder and its association with adherence to antiretroviral therapy and quality of life: cross-sectional survey of people living with HIV/AIDS in Northwest Ethiopia

et al. 2020

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Background Major depression is believed to affect treatment adherence and overall quality of life (QoL) of people living with HIV/AIDS (PLWHA). Comorbid major depression contributes to a two-fold higher risk of mortality among PLWHA. Understanding the relationships of major depression, adherence to antiretroviral therapy (ART) and QoL is important to identify areas for intervention. The aim of this study is to examine relationship of major depressive disorder (MDD) and adherence to ART with QoL, and to investigate socio-demographic and clinical factors associated with MDD, adherence and QoL among PLWHA in Northwest Ethiopia. Method A cross-sectional study was conducted in the ART clinic of Felege-Hiwot referral hospital in Northwest Ethiopia from July to October 2019. Adult PLWHA were selected using a systematic random sampling technique. Data were collected using interview administered questionnaires and chart reviews. Mini International Neuropsychiatric Interview and WHOQOL-HIV-BREF-Eth instruments were used to measure MDD and QoL respectively. Adherence to ART was assessed using pill count data from patients’ adherence monitoring chart. Univariate and multivariate Poisson regressions were used to assess associations of socio-demographic and clinical factors with MDD and adherence to ART. A multivariate linear regression was used to examine the associations of both MDD and adherence with overall QoL. Result Of the total of 393 invited participants, 391 (99.5%) completed the interviews. MDD was negatively associated with overall QoL: participants with MDD had a lower QoL score of 0.17 points compared to those with no MDD. MDD was associated with reduced adherence to ART when functional disability was controlled (RR = 1.43; 95%CI = 1.05, 1.96; p = 0.025). However, there was no statistical association between adherence to ART and overall QoL. Functional disability was associated with both MDD (RR = 5.07; 95%CI = 3.27,7.86; p < 0.001) and overall QoL (β = 0.29; 95%CI = 0.21,0.36; p < 0.001). Conclusion The relationship between MDD and QoL indicates the need for feasible, acceptable and evidence-based mental health interventions to reduce depression and improve overall QoL of PLWHA. We recommend future studies investigate causal relationships of MDD, adherence to ART and QoL of PLWHA to better understand priority areas for intervention.

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“…Likewise, living with HIV significantly increased MD among participants. Previous study noted that HIV significantly increase the risk of MD and that relationship between HIV and MD is mediated through more than 10 risk factors for depression (33). Additionally, being 30+ years of age (older age) was found to significantly increase MD.…”

Section: Discussionmentioning

confidence: 81%

Prevalence and Factors Associated with Major Depression Among Female Sex Workers in Post-Conflict Gulu District: A Cross-Sectional Study

Ouma

Tumwesigye

Ndejjo

et al. 2020

Preprint

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Background: Depression is the world’s leading cause of disability and a major contributor to the overall global burden of disease. Female sex workers operating in conflict-affected settings could be more prone to depression, yet the prevalence and factors associated with depression among this special population remain inadequately addressed. This study thus aimed to determine the prevalence and factors associated with major depression among female sex workers in post-conflict Gulu district. Methods: This cross-sectional study was conducted among 300 randomly selected female sex workers in Gulu district between March and June 2020. Possible factors associated with depression were assessed using pre-tested semi-structured questionnaire and participants assessed for major depression using Mini-International Neuropsychiatric Interview (MINI) version 7.0.0. We utilized STATA 14.0 for univariate, bivariate and multivariate data analyses.Results: The mean age of study participants was 26.4 years (SD = 6), 57.7% attained primary education, 51.7% never married and 42.1% were living with HIV. Almost half (47.7%) of the participants had major depression, of whom half (50.4%) had severe depression and one-thirds (34.3%) had suicidal ideation. At multivariate level, factors that showed positive association with major depression were: psychological stressor (aOR = 11.0, 95%CI: 5.77-20.86), living with HIV (aOR= 2.32, 95%CI: 1.29-4.15), being verbally abused (aOR = 2.27, 95%CI: 1.26-4.07), and being 30+ years of age (aOR = 1.95, 95%CI: 1.05-3.61). Meanwhile, factors that showed negative association with major depression were: providing sexual services at client’s place (aOR=0.46, 95%CI: 0.24-0.91), using modern family planning method (aOR=0.47, 95%CI: 0.25-0.87), and daily intake of alcohol (aOR=0.50, 95%CI: 0.28-0.88).Conclusion: The findings underscore the high prevalence of major depression among female sex workers driven by psychological stress, living with HIV/AIDs, being verbally abused by clients and being 30+years of age. The high prevalence of major depression has important public health ramifications at individual and societal levels and requires urgent attention of all stakeholders.

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A systematic review and meta-analysis of epidemiology of depression in people living with HIV in east Africa

Cited by 70 publications

References 39 publications

Prevalence of depressive symptoms among nurses in China: A systematic review and meta-analysis

Prevalence of depressive symptoms among nurses in China: A systematic review and meta-analysis

Major depressive disorder and its association with adherence to antiretroviral therapy and quality of life: cross-sectional survey of people living with HIV/AIDS in Northwest Ethiopia

Prevalence and Factors Associated with Major Depression Among Female Sex Workers in Post-Conflict Gulu District: A Cross-Sectional Study

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