A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk

Ye, Zhuo-Miao; Li, Lijuan; Luo, Meiling; Qing, Hong-Yuan; Zheng, Jinghui; Zhang, Chi; Lu, Yong; Tang, Youming

doi:10.18632/aging.104128

Cited by 7 publications

(5 citation statements)

References 87 publications

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“…Single nucleotide polymorphisms (SNPs) have become important predictors of tumors and indicators of the effectiveness of response to radiation therapy. [6][7][8] SNPs may affect gene expression, mRNA stability, and protein function. 9 Among them, SNPs of the fat mass and obesity associated gene (FTO), the first obesity-related gene identified by genome-wide association studies (GWAS), has been linked to the occurrence, progression, and prognosis of many cancers, including breast cancer, ovarian cancer, Wilms tumor, thyroid cancer, pancreatic cancer, prostate cancer, colorectal cancer, etc.…”

Section: Introductionmentioning

confidence: 99%

FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma

Xiao¹,

Zhou²

2021

PGPM

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Background Nasopharyngeal carcinoma (NPC) is mainly concentrated in East and Southeast Asia. This study aims to elucidate the potential associations of functional SNPs in the fat mass and obesity associated gene (FTO) with NPC risk and radiotherapy outcomes in a Chinese population. Methods Functional SNP rs1477196 G>A, rs9939609 T>A, rs7206790 C>G, and rs8047395 A>G were genotyped and evaluated for their associations with NPC risk and radiotherapy outcomes. Results Both rs9939609 (allele A versus allele T: OR=1.59; 95% CI=1.17–2.17; P -value=0.003) and rs8047395 (allele G versus allele A: OR=0.76; 95% CI=0.64–0.9; P -value=0.002) were significantly associated with risk of NPC. GTEx showed risk allele A of rs9939609 and rs8047395 were significantly associated with higher FTO mRNA levels in skeletal muscle tissue, which also corroborated our findings. Meanwhile, both rs1477196 (allele A versus allele G: OR=1.64; 95% CI=1.09–2.49; P -value=0.019) and rs9939609 (allele A versus allele T: OR=0.61; 95% CI=0.43–0.87; P -value=0.006) were significantly associated with complete remission (CR) of NPC. Conclusion Our study identified that FTO polymorphisms contributed to the susceptibility and radiotherapy efficacy of NPC. These results shed light on the potential of establishing markers for predicting risk and personalized treatment of NPC.

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Section: Introductionmentioning

confidence: 99%

FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma

Xiao¹,

Zhou²

2021

PGPM

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“…Notably, CD4 + Treg cells possess potent immunosuppressive capabilities, thus fostering tumor advancement by impeding the efficacy of anti-tumor treatment [ 43 , 44 ]. Regulatory T (Treg) cells, known for their immunosuppressive functions, have been implicated in promoting tumor immune evasion and resistance to various cancer therapies [ 17 ]. Studies have shown that increased infiltration of Tregs within the tumor microenvironment correlates with poor prognosis and resistance to chemotherapy and immunotherapy in multiple cancer types, including pancreatic cancer [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Stimulating and mobilizing the human immune system to enhance the anti-tumor ability of TME has emerged as a promising research direction for PC immunotherapy. PC Patients with a smaller volume of stromal cells and higher levels of peritumoral T lymphocytes, monocytes/macrophages, CTLA4, and PDL-1 experienced poorer overall survival (OS) [ [16] , [17] , [18] , [19] ]. Tumor-associated macrophages (TAMs) play a crucial role in regulating the response to TME treatment.…”

Section: Introductionmentioning

confidence: 99%

Identification of gemcitabine resistance-related AHNAK2 gene associated with prognosis and immune infiltration in pancreatic cancer

Ou,

Tian,

et al. 2024

Heliyon

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“…Последний метаанализ данных, включающий 36 360 больных РПЖ и 54 752 контрольных лица, выявил статистически достоверную связь между TP53 rs9895829 (ОР 1,23, 95 % ДИ 1,14-1,33), VDR rs2228570 (ОР 1,98, 95 % ДИ 1,50-2,61) и CTLA-4 rs231775 (ОР 0,33, 95 % ДИ 0,22-0,49) и РПЖ [48].…”

Section: однонуклеотидный полиморфизм последовательностей (Single Nuc...unclassified

Descriptive, analytical and molecular epidemiology of pancreatic cancer

2022

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The purpose of the study was to present current data on the role of lifestyle and heredity factors in the etiology of pancreatic cancer (PC). Material and Methods. A systemic literature search was conducted using Medline and Elibrary databases. Results. Pancreatic cancer is the 9th leading cause of cancer-related deaths worldwide. PC has an extremely poor prognosis. The 5-year survival rate of patients with PC does not exceed 9 %. The highest incidence and mortality rates from PC are found in Eastern Europe, including Russia. The incidence of PC in 2019 was 9.3 per 100,000 males and 5.7 per 100,000 females. In Russia, PC incidence and mortality rates in both males and females show a steady increase. Risk factors associated with PC include smoking, heavy alcohol drinking, overweight and obesity, diabetes and chronic pancreatitis. The microbiome of the oral cavity and colon infuence the risk of PС. Approximately 10 % of PC is estimated to have familial inheritance. The risk of PC in patients with inherited syndromes ranges from 2 (hereditary breast and ovarian cancer syndrome) to 132 (Peutz-Jeghers syndrome). Regions of the genome containing variants of single nucleotide polymorphism (SNPs), which are more common in patients with PC than in healthy people, were identifed. The most common somatic mutations include mutations in the driver genes of prostate cancer, which include the KRAS oncogene and tumor suppressor genes TP53, CDKN2A, and SMAD4.The less common mutations of genes include AIB1/NCOA, ERBB2/HER2/EGFR2, AKT2, BRAF, CCND1, RB1, etc. They are identifed as “passenger” mutations although the combined effect of polymorphism of these genes can be signifcant and comparable to the infuence of the driver gene. Conclusion. A signifcant disadvantage of our understanding of the process of carcinogenesis is the lack of information about carcinogenic factors that cause specifc mutations, i.e. the formation of mutational signatures. To solve this problem, in 2017, the international scientifc project GRAND CHALLENGE “Mutograph” was launched. The scientists of the Department of Cancer Epidemiology of N. N. Blokhin National Medical Research Center of Oncology are members of the international team working on this project.

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A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk

Cited by 7 publications

References 87 publications

FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma

FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma

Identification of gemcitabine resistance-related AHNAK2 gene associated with prognosis and immune infiltration in pancreatic cancer

Descriptive, analytical and molecular epidemiology of pancreatic cancer

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