A systematic review and network meta-analysis comparing various non-pharmacological treatments for older people with mild cognitive impairment

Wang, Yuan‐Yuan; Wang, Xiao-xian; Chen, Lei; Liu, Yan

doi:10.1016/j.ajp.2023.103635

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Additionally, we opted for cycling exercises, given their documented cognitive benefits compared with walking or running exercises [73]. Notably, our research is distinctive in its clinical focus, aiming to elucidate the potential for maximizing cognitive benefits through combined training compared with physical training alone, which is considered a leading nonpharmacological therapy [74]. The group engaging in training simultaneously with cognitive games exhibited a notably superior effect, and this positive impact persisted for at least four weeks post-training.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Ayed,

Aouichaoui,

Ammar

et al. 2024

EJIHPE

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Background: This study investigated whether combining simultaneous physical and cognitive training yields superior cognitive outcomes compared with aerobic training alone in individuals with mild cognitive impairment (MCI) and whether these benefits persist after four weeks of detraining. Methods: Forty-four people with MCI (11 males and 33 females) aged 65 to 75 years were randomly assigned to an 8-week, twice-weekly program of either aerobic training (AT group, n = 15), aerobic training combined with cognitive games (ACT group, n = 15), or simply reading for controls (CG group, n = 14). Selective attention (Stroop), problem-solving (Hanoi Tower), and working memory (Digit Span) tasks were used to assess cognitive performances at baseline, in the 4th (W4) and 8th weeks (W8) of training, and after 4 weeks of rest (W12). Results: Both training interventions induced beneficial effects on all tested cognitive performance at W4 (except for the number of moves in the Hanoi tower task) and W8 (all p <0.001), with the ACT group exhibiting a more pronounced positive impact than the AT group (p < 0.05). This advantage was specifically observed at W8 in tasks such as the Stroop and Tower of Hanoi (% gain ≈40% vs. ≈30% for ACT and AT, respectively) and the digit span test (% gain ≈13% vs. ≈10% for ACT and AT, respectively). These cognitive improvements in both groups, with the greater ones in ACT, persisted even after four weeks of detraining, as evidenced by the absence of a significant difference between W8 and W12 (p > 0.05). Concerning neuropsychological assessments, comparable beneficial effects were recorded following both training regimens (all p < 0.05 from pre- to post-intervention). The control group did not show any significant improvement in most of the cognitive tasks. Conclusions: The greater mid-term and long-lasting effects of combined simultaneous physical–cognitive training underscores its potential as a cost-effective intervention for the prevention and management of cognitive decline. While these results are valuable in guiding optimal physical and mental activity recommendations for adults with MCI, further neurophysiological-based studies are essential to offer robust support and deepen our understanding of the mechanisms underlying these promising findings.

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Section: Strengths and Limitationsmentioning

confidence: 99%

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Ayed,

Aouichaoui,

Ammar

et al. 2024

EJIHPE

View full text Add to dashboard Cite

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“…Thus, delaying MCI’s progression is crucial to slowing patients’ cognitive decline and reducing caregivers’ burden. Early MCI interventions encompass both pharmacological and non-pharmacological treatments ( Wang et al, 2023 ). Given the limited efficacy of drugs, non-drug therapies are now the focal point for delaying MCI progression ( Ligo Teixeira et al, 2012 ; Cooper et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Intervention of computer-assisted cognitive training combined with occupational therapy in people with mild cognitive impairment: a randomized controlled trial

Wen,

Song,

Tian

et al. 2024

Front. Aging Neurosci.

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ObjectiveInvestigate the impact of combined computerized cognitive training and occupational therapy on individuals with mild cognitive impairment (MCI).MethodsWe randomly assigned 118 MCI patients into two groups: a combined intervention group (n = 37) and a control group (n = 81), the latter receiving standard nursing care. The intervention group additionally underwent 12 weeks of computerized cognitive training and occupational therapy. Blind assessors evaluated cognitive performance, anxiety, depression, and daily living activities before the intervention, post-intervention, and at a 3-month follow-up.ResultsRepeated-measures analysis of variance showed that the sMoCA scores, HAMA scores, and ADL scores of the experimental group at T2 (post-intervention) and T3 (3-month follow-up) were higher than those of the control group, and the difference was statistically significant (p < 0.001, p < 0.001, p = 0.026).ConclusionComputerized cognitive training combined with occupational therapy can improve patients’ cognitive status, enhance their compliance with continuing care, and maintain their anxiety and self-care ability at a stable level.Clinical trial registrationhttps://www.chictr.org.cn/index.html, identifier ChiCTR2200065014.

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Use of Complementary and Integrative Medicine for Alzheimer’s Disease and Cognitive Decline

Nguyen,

Oughli,

Lavretsky

2024

JAD

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Integrative medicine takes a holistic approach because it considers multiple aspects of the individual. This includes a person’s physical, emotional, interpersonal, behavioral, nutritional, environmental, and spiritual dimensions of wellbeing that contribute to the Whole Person Health. There is increasing interest and popularity of integrative approaches to treating cognitive decline and dementia because of the multifactorial nature of aging and the limited pharmacological interventions available in treating cognitive decline and dementia, particularly Alzheimer’s disease, the most common type of dementia. This review summarizes the existing evidence using complementary and integrative medicine therapies in cognitive decline and Alzheimer’s disease. This includes the use of mind-body therapies, lifestyle interventions (nutritional, physical exercise, stress reduction), and other integrative modalities. Unfortunately, there are still limited studies available to guide clinicians despite the increasing popularity of integrative treatments.

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A systematic review and network meta-analysis comparing various non-pharmacological treatments for older people with mild cognitive impairment

Cited by 4 publications

References 42 publications

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Intervention of computer-assisted cognitive training combined with occupational therapy in people with mild cognitive impairment: a randomized controlled trial

Use of Complementary and Integrative Medicine for Alzheimer’s Disease and Cognitive Decline

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