A systematic review identifying outcomes and outcome measures in Dupuytren’s disease research

Abstract

This systematic review summarizes the outcome reporting standards in Dupuytren’s disease treatment research. A search of Ovid Medline, Ovid Embase, and CINAHL was conducted. Randomized controlled trials, cohort studies, and case series published between 1997 and 2017, investigating treatment of Dupuytren’s disease with fasciectomy, fasciotomy, or collagenase, were eligible for inclusion. Range of motion was the most commonly reported outcome, appearing in 77% of included studies. Outcomes, such as range of motion, recurrence, and clinical success, were frequently defined, however many different definitions were used. We identified 37 unique measurement methods for range of motion, 28 for recurrence, and 25 for clinical success. Most outcomes were assessed at multiple time points, and only a few studies reported results according to established clinical significance thresholds. Development of a core outcome set will help standardize outcome reporting, and ensure future research in this field is relevant, interpretable, and amenable to systematic review and/or meta-analysis.

Improving the Science in Plastic Surgery

“…Data from such studies cannot be pooled in systematic reviews or meta-analyses because of the heterogeneity of outcomes. [43][44][45] The creation of a core outcome set for each common surgical A core outcome set is an agreed-upon list of outcomes deemed to be the most important to measure in clinical research. 46 Outcomes within a core outcome set are to be measured and reported, as a minimum, in all clinical research studies of the given health state.…”

“…Outcome Measurement 49 and the Core Outcome Sets and Measures Adapted to Surgery [43][44][45]50 research group.…”

Treatment of Dupuytren’s Contracture With Collagenase: A Systematic Review

“…The heterogeneity of reporting and measuring outcomes is an existing trend in Dupuytren's research. 36 The lack of reported analyses of variance also limited measurement of heterogeneity between studies. By excluding articles from recurrence rates with follow-up times of less than 1 year, contractures that recur shortly after CCH treatment are overlooked; conversely, the lack of long-term follow-up also presents challenges in effectively tracking recurrences.…”

Acquired Disorders of Collagen and Elastin

“…In case of clear functional disorders, surgical intervention with removal of the palmar aponeurosis (fasciotomy with full skin transplantation, Z-plastic, or secondary granulation) is indicated. By injecting the clostridium histolyticum isolated collagenase, a significant reduction in contractures and an improvement in finger mobility can be achieved (Karpinski et al 2020).…”