A Systematic Review Into the Influence of Temperature on Fibromyalgia Pain: Meteorological Studies and Quantitative Sensory Testing

Berwick, Richard; Siew, Sara; Andersson, David A.; Göebel, Andreas

doi:10.1016/j.jpain.2020.12.005

Cited by 19 publications

(18 citation statements)

References 85 publications

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“…IgG from each of the 8 individual patients, but not from any of the 6 HC subjects, rapidly produced mechanical hypersensitivity (Figure 1, A-F). In addition to pressure sensitivity, patients frequently report that pain is exacerbated by cold temperatures, and quantitative sensory testing has demonstrated an increased cold pain sensitivity in FMS (1,2,4,16). In good agreement with patient observations, administration of IgG from 7 of the 8 FMS patients gave rise to a significantly increased sensitivity to noxious cold in mice (Figure 1, G-L).…”

Section: Passive Transfer Of Sensory Hypersensitivitiessupporting

confidence: 70%

“…Fibromyalgia syndrome (FMS) is a chronic pain condition characterized by widespread pain, augmented pain sensitivity to mechanical pressure and cold temperatures (1)(2)(3)(4), as well as fatigue and emotional distress (5)(6)(7). The prevalence of FMS is at least 2% (8), and approximately 80% of FMS patients are women.…”

Section: Introductionmentioning

confidence: 99%

“…The dashed lines indicate the lower limit of quantification (LLOQ) and the dotted lines indicate the lower limit of detection (G-M). Line and whiskers indicate mean ± SEM (n =[4][5][6]. Differences between FMS IgG and HC IgG were analyzed with Mann-Whitney U test (B-F).…”

mentioning

confidence: 99%

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Passive transfer of fibromyalgia symptoms from patients to mice

Göebel¹,

Krock²,

Gentry³

et al. 2021

Journal of Clinical Investigation

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144

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Section: Passive Transfer Of Sensory Hypersensitivitiessupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Passive transfer of fibromyalgia symptoms from patients to mice

Göebel¹,

Krock²,

Gentry³

et al. 2021

Journal of Clinical Investigation

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144

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“…between groups of individuals. A recent systematic review ( 47 ) examined the perception of thermal stimulation in fibromyalgia and showed that most studies using QST reported hyperalgesia to cold (82% of the studies) and heat stimulations (77% of the studies) in fibromyalgia but no alterations in the detection of non-noxious cold stimulations (70.6%). However, results on the alterations of perception of noxious and non-noxious stimuli for other sensory modalities in fibromyalgia remain conflicting.…”

Section: Introductionmentioning

confidence: 99%

Tactile Detection in Fibromyalgia: A Systematic Review and a Meta-Analysis

et al. 2021

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Fibromyalgia is a chronic pain syndrome characterized by sensorimotor deficits and distortions of body representation, that could both be caused by alterations in sensory processing. Several studies suggest a hypersensitivity to various sensory stimulations in fibromyalgia but results on detection of both noxious and non-noxious tactile stimulation, which are particularly relevant for body representation and motor control, remain conflicting. Therefore, the aim of this study is to systematically review and quantify the detection thresholds to noxious and non-noxious tactile stimuli in individuals with fibromyalgia compared to pain-free controls. A systematic review and a meta-analysis were performed in the MEDLINE, EMBASE, CINAHL, Cochrane, PsycInfo and Web of Science databases using keywords related to fibromyalgia, tactile pain detection threshold, tactile detection threshold and quantitative sensory testing. Nineteen studies were included in the review, with 12 in the meta-analysis. Despite the heterogeneity of the results, the data from both the review and from the meta-analysis suggest a trend toward hyperalgesia and no difference of sensitivity to non-noxious tactile stimuli in participants with fibromyalgia compared to healthy controls. This contradicts the hypothesis of a general increase in responsiveness of the central nervous system to noxious and non-noxious stimulations in fibromyalgia. This study shows no alteration of the sensitivity to non-noxious tactile stimulation in fibromyalgia, suggesting that an altered unimodal processing is not sufficient to explain symptoms such as sensorimotor impairments and body representation distortions. Future research should investigate whether alterations in multisensory integration could contribute to these symptoms.

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“…Patients and healthy controls were always tested by the same examiner at the same room temperature, given that the ambient temperature has an in uence on pain sensitivity in FMS. 40…”

Section: Microbiome Analysismentioning

confidence: 99%

Fibromyalgia-Associated Hyperalgesia and Psychopathological Alterations are Unrelated to Gut Microbiome Diversity

Weber

Tatzl

Kashofer

et al. 2021

Preprint

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Fibromyalgia-syndrome (FMS) is a complex disease characterized by chronic widespread pain and additional symptoms including depression, cognitive dysfunction (“fibro-fog”) and maldigestion. We examined whether FMS-related pain parameters assessed by quantitative sensory testing (QST) are related to changes of microbial diversity.We recruited 25 patients with FMS and 26 age- and sex-matched healthy controls. Medical background, food habits, psychopathology and quality of life were assessed with questionnaires. Stool samples were analyzed by 16S rRNA gene amplification and sequencing. QST was performed according to the protocol of the German Network for Neuropathic Pain.QST showed that both lemniscal and spinothalamic afferent pathways are altered in FMS patients relative to healthy controls and that peripheral as well as central pain sensitization processes are manifest. Psychometric assessment revealed enhanced scores of depression, anxiety and stress. In contrast, neither the composition nor the alpha- and beta-diversity of the fecal microbiome was changed in FMS patients.FMS patients segregate from healthy controls in various parameters of QST and psychopathology, but not in terms of composition and diversity of the fecal microbiome. Despite consideration of several confounding factors we conclude that the impact of the gut microbiome on the pathophysiology of FMS is limited.

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A Systematic Review Into the Influence of Temperature on Fibromyalgia Pain: Meteorological Studies and Quantitative Sensory Testing

Cited by 19 publications

References 85 publications

Passive transfer of fibromyalgia symptoms from patients to mice

Passive transfer of fibromyalgia symptoms from patients to mice

Tactile Detection in Fibromyalgia: A Systematic Review and a Meta-Analysis

Fibromyalgia-Associated Hyperalgesia and Psychopathological Alterations are Unrelated to Gut Microbiome Diversity

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