A systematic review into the role of pubertal timing and the social environment in adolescent mental health problems

Vijayakumar, Nandita; Whittle, Sarah

doi:10.1016/j.cpr.2023.102282

Cited by 11 publications

(4 citation statements)

References 189 publications

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“…Second, as youth self-report of internalising problems was first measured at the six-month follow-up, we were only able to control for earlier internalising problems at this timepoint and not at baseline when the neuroimaging data were first collected. Finally, the current study focused on brain maturation and the emergence of internalising problems in youth, but a host of socio-environmental factors, and other biological processes like puberty, are known to influence neurodevelopment and mental health risk (58)(59)(60). Future work should examine the complex interplay between biological and psychosocial factors and how they shape developmental outcomes during adolescence and beyond.…”

Section: Discussionmentioning

confidence: 99%

Multimodal brain age indicators of internalising problems in adolescence: A longitudinal investigation

MacSweeney,

Beck,

Whitmore

et al. 2024

Preprint

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Background: Adolescence is a time of increased risk for the onset of internalising problems, particularly in females. However, how individual differences in brain maturation relate to the increased vulnerability for internalising problems in adolescence remains poorly understood due to a scarcity of longitudinal studies. Methods: Using Adolescent Brain Cognitive Development (ABCD) Study data, we examined longitudinal associations between multimodal brain age and youth internalising problems. Brain age models were trained, validated, and tested independently on T1-weighted (T1; N=9523), diffusion tensor (DTI; N=8834), and resting-state functional (rs-fMRI; N=8233) MRI data at baseline (Mage= 9.9 years) and 2-year follow-up (Mage= 11.9 years). Self-reported internalising problems were measured at 3-year follow-up (Mage= 12.9 years) using the Brief Problem Monitor.Results: Latent change score models demonstrated that although brain age gap (BAG) at baseline was not related to later internalising problems, an increase in BAG between timepoints was positively associated with internalising problems at 3-year follow-up in females but not males. This association between an increasing BAG and higher internalising problems was observed in the T1 (β=0.071, SE=0.050, p=0.009) and rs-fMRI (β=0.091, SE=0.025, p=0.005) models but not DTI (β=-0.024, SE=0.053, p=0.648), and remained significant when accounting for earlier internalising problems. Conclusions: A greater increase in BAG over time may reflect the heightened vulnerability shown by female youth to internalising problems. Longitudinal research is necessary to understand if this increasing BAG signifies accelerated brain development and its relationship to the trajectory of internalising problems throughout adolescence.

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Section: Discussionmentioning

confidence: 99%

Multimodal brain age indicators of internalising problems in adolescence: A longitudinal investigation

MacSweeney,

Beck,

Whitmore

et al. 2024

Preprint

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“…The first aim was to examine associations between pubertal timing and corticolimbic connectivity, hypothesizing that earlier timing would be related to decreased connectivity between amygdala/hippocampus and higher-order cognitive networks (e.g., cingulo-opercular, frontoparietal and default mode). Next, we examined whether functional connectivity mediated the well-characterized association between pubertal timing and mental health problems, focusing on depression and rule-breaking delinquency that have been most consistently implicated in the literature (Vijayakumar & Whittle, 2022). It was hypothesized that decreased connectivity of the amygdala/hippocampus and higher-order networks would significantly mediate the association between earlier timing and greater mental health problems.…”

Section: Puberty and Corticolimbic Connectivitymentioning

confidence: 99%

Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems

Vijayakumar

Whittle

Silk

2023

Preprint

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Background: Undergoing puberty ahead of peers (earlier pubertal timing) is an important risk factor for mental health problems during early adolescence. The current study examined pathways between pubertal timing and mental health via connectivity of neural systems implicated in emotional reactivity and regulation (specifically corticolimbic connections) in 9- to 14-year-olds. Method: Research questions were examined in the Adolescent Brain Cognitive Development (ABCD) Study, a large population representative sample in the United States. Linear mixed models examined associations between pubertal timing and resting-state corticolimbic connectivity. Significant connections were examined as potential mediators of the relationship between pubertal timing and mental health (withdrawn depressed and rule-breaking delinquency) problems. Exploratory analyses interrogated whether the family environment moderated neural risk patterns in those undergoing puberty earlier than their peers. Results: Earlier pubertal timing was related to decreased connectivity between limbic structures (bilateral amygdala and right hippocampus) and the cingulo-opercular network (CON), as well as between the left hippocampus and ventral attention network (VAN). Corticolimbic connections also mediated the relationship between earlier pubertal timing and increased withdrawn depressed problems (but not rule-breaking delinquency). Finally, parental acceptance buffered against limbic-CON connectivity patterns that were implicated in withdrawn depressed problems in those undergoing puberty earlier than their peers. Conclusion: Findings highlight the role of decreased corticolimbic connectivity in mediating pathways between earlier pubertal timing and withdrawn depressed problems, and we present preliminary evidence that the family environment may buffer against these neural risk patterns during early adolescence.

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“…The goal of the current study was to investigate associations between pubertal timing, corticolimbic connectivity and mental health problems. We focus specifically on (i) connectivity of two limbic structures, the amygdala and hippocampus, given the density of pubertal hormone receptors in these regions, and (ii) depressive and rule-breaking problems as outcome measures as they have been most consistently implicated in relation to earlier pubertal timing (Vijayakumar & Whittle, 2023). We examined their connectivity to large scale, distributed functional networks in the cortex during resting-state, building upon research that has implicated these networks in mental health problems.…”

Section: The Current Studymentioning

confidence: 99%

Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems

2023

Self Cite

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Background Undergoing puberty ahead of peers (‘earlier pubertal timing’) is an important risk factor for mental health problems during early adolescence. The current study examined pathways between pubertal timing and mental health via connectivity of neural systems implicated in emotional reactivity and regulation (specifically corticolimbic connections) in 9- to 14-year-olds. Method Research questions were examined in the Adolescent Brain Cognitive Development (ABCD) Study, a large population representative sample in the United States. Linear mixed models examined associations between pubertal timing and resting-state corticolimbic connectivity. Significant connections were examined as potential mediators of the relationship between pubertal timing and mental health (withdrawn depressed and rule-breaking) problems. Exploratory analyses interrogated whether the family environment moderated neural risk patterns in those undergoing puberty earlier than their peers. Results Earlier pubertal timing was related to decreased connectivity between limbic structures (bilateral amygdala and right hippocampus) and the cingulo-opercular network, left amygdala and somatomotor (mouth) network, as well as between the left hippocampus and ventral attention network and visual network. Corticolimbic connections also mediated the relationship between earlier pubertal timing and increased withdrawn depressed problems (but not rule-breaking problems). Finally, parental acceptance buffered against connectivity patterns that were implicated in withdrawn depressed problems in those undergoing puberty earlier than their peers. Conclusion Findings highlight the role of decreased corticolimbic connectivity in mediating pathways between earlier pubertal timing and withdrawn depressed problems, and we present preliminary evidence that the family environment may buffer against these neural risk patterns during early adolescence.

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A systematic review into the role of pubertal timing and the social environment in adolescent mental health problems

Cited by 11 publications

References 189 publications

Multimodal brain age indicators of internalising problems in adolescence: A longitudinal investigation

Multimodal brain age indicators of internalising problems in adolescence: A longitudinal investigation

Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems

Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems

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