A systematic review of 3-D printing in cardiovascular and cerebrovascular diseases

Sun, Zhonghua; Lee, Shen Yuan

doi:10.14744/anatoljcardiol.2017.7464

Cited by 44 publications

(63 citation statements)

References 61 publications

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“…Some recent systematic reviews have shown the value of 3D printing in cardiovascular and liver diseases. A systematic review of 48 studies has summarised the findings of using 3D printed models in cardiovascular and cerebrovascular diseases, with high accuracy of 3D printing in reproducing complex cardiac anatomy and pathologies, and usefulness in both education and surgical planning (8). Another recent systematic review of 28 studies focuses on the 3D printing in congenital heart disease (10).…”

Section: Discussionmentioning

confidence: 99%

“…Patient-specific 3D printed models based on computed tomography (CT) or magnetic resonance imaging (MRI) data have been shown to accurately replicate complex anatomical structures and pathologies when compared to original source images (2)(3)(4)7). 3D printed models can also be used to assist pre-surgical planning and simulation, improve understanding of anatomy and individual lesions (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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A systematic review of clinical value of three-dimensional printing in renal disease

Sun

Liu

2018

Quant. Imaging Med. Surg.

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The aim of this systematic review is to analyse current literature related to the clinical value of three-dimensional (3D) printed models in renal disease. A literature search of PubMed and Scopus databases was performed to identify studies reporting the clinical application and usefulness of 3D printed models in renal disease. Fifteen studies were found to meet the selection criteria and were included in the analysis. Eight of them provided quantitative assessments with five studies focusing on dimensional accuracy of 3D printed models in replicating renal anatomy and tumour, and on measuring tumour volume between 3D printed models and original source images and surgical specimens, with mean difference less than 10%. The other three studies reported that the use of 3D printed models significantly enhanced medical students and specialists' ability to identify anatomical structures when compared to two-dimensional (2D) images alone; and significantly shortened intraoperative ultrasound duration compared to without use of 3D printed models. Seven studies provided qualitative assessments of the usefulness of 3D printed kidney models with findings showing that 3D printed models improved patient's understanding of renal anatomy and pathology; improved medical trainees' understanding of renal malignant tumours when compared to viewing medical images alone; and assisted surgical planning and simulation of renal surgical procedures with significant reductions of intraoperative complications. The cost and time associated with 3D printed kidney model production was reported in 10 studies, with costs ranging from USD$100 to USD$1,000, and duration of 3D printing production up to 31 h. The entire process of 3D printing could take up to a few days. This review shows that 3D printed kidney models are accurate in delineating renal anatomical structures and renal tumours with high accuracy. Patient-specific 3D printed models serve as a useful tool in preoperative planning and simulation of surgical procedures for treatment of renal tumours. Further studies with inclusion of more cases and with a focus on reducing the cost and 3D model production time deserve to be investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic review of clinical value of three-dimensional printing in renal disease

Sun

Liu

2018

Quant. Imaging Med. Surg.

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“…Three‐dimensional (3D) printing technology has shown increasing use in the medical field in recent years, such as creating customised prosthetics, implants, fixtures and surgical tools, as well as reproducing patient‐specific 3D printed models for surgical preparation . In order to achieve a more comprehensive viewing of CHD, 3D physical models of the heart and blood vessels can be fabricated based on volumetric scans such as computed tomography (CT), magnetic resonance imaging (MRI) and echocardiography imaging data which allow full exploitation of the 3D potential of the scans and provide more information than conventional imaging visualisations …”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional printing in congenital heart disease: A systematic review

Lau

Sun

2018

J of Medical Radiation Sci

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115

113

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Three‐dimensional (3D) printing has shown great promise in medicine with increasing reports in congenital heart disease (CHD). This systematic review aims to analyse the main clinical applications and accuracy of 3D printing in CHD, as well as to provide an overview of the software tools, time and costs associated with the generation of 3D printed heart models. A search of different databases was conducted to identify studies investigating the application of 3D printing in CHD. Studies based on patient's medical imaging datasets were included for analysis, while reports on in vitro phantom or review articles were excluded from the analysis. A total of 28 studies met selection criteria for inclusion in the review. More than half of the studies were based on isolated case reports with inclusion of 1–12 cases (61%), while 10 studies (36%) focused on the survey of opinion on the usefulness of 3D printing by healthcare professionals, patients, parents of patients and medical students, and the remaining one involved a multicentre study about the clinical value of 3D printed models in surgical planning of CHD. The analysis shows that patient‐specific 3D printed models accurately replicate complex cardiac anatomy, improve understanding and knowledge about congenital heart diseases and demonstrate value in preoperative planning and simulation of cardiac or interventional procedures, assist surgical decision‐making and intra‐operative orientation, and improve patient‐doctor communication and medical education. The cost of 3D printing ranges from USD 55 to USD 810. This systematic review shows the usefulness of 3D printed models in congenital heart disease with applications ranging from accurate replication of complex cardiac anatomy and pathology to medical education, preoperative planning and simulation. The additional cost and time required to manufacture the 3D printed models represent the limitations which need to be addressed in future studies.

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“…The applications of 3D printed cardiac models are vast in scope and include, but are not limited to: (i) assisting in diagnostics, (ii) optimizing therapeutic outputs, (iii) testing novel devices, (iv) assessing patient-specific suitability for treatments, (v) providing visualized insight for surgical procedures, (vi) allowing for performance of parametric studies on hydrodynamics, and (vii) validating computational simulations. Additionally, 3D printed cardiac models present a robust didactic and communication medium for students, patients, and the greater medical public [21,23,74]. So far, considering the requisite precision, formability, and stability of 3D printed models, current strategies for cardiovascular 3D printing in clinical practices have relied on robust, non-living manufacturing technologies.…”

Section: Cardiovascular System and Tissue Modelsmentioning

confidence: 99%

“…3D scanners, computed tomography (CT), magnetic resonance imaging (MRI) systems, and other imaging technologies, as well as computer-aided design (CAD) software, are employed to collect, draw, and digitize the complex structural information of native tissues in order to create 3D printable files, (typically stereolithography (STL) files) [16,20]. Based on a highly precise, layer-by-layer building process, 3D printing techniques have been utilized to create patient-specific models for cardiovascular surgeons to visualize anatomical structures, thus facilitating a more comprehensive understanding of tissue abnormalities and promoting better surgical procedures [21–23]. For engineered active tissues/organs, 3D bioprinting is able to fabricate complex tissue architecture with spatiotemporal distribution of bioactive substances (cells, growth factors, and others) to better guide tissue regeneration [16,19,24].…”

Section: Introductionmentioning

confidence: 99%

3D bioprinting for cardiovascular regeneration and pharmacology

Cui

Miao

Esworthy

et al. 2018

Advanced Drug Delivery Reviews

150

116

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Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of the most advanced techniques for creating complicated cardiovascular implants with biomimetic features, which are capable of recapitulating both the native physiochemical and biomechanical characteristics of the cardiovascular system. The present review provides an overview of the cardiovascular system, as well as describes the principles of, and recent advances in, 3D bioprinting cardiovascular tissues and models. Moreover, this review will focus on the applications of 3D bioprinting technology in cardiovascular repair/regeneration and pharmacological modeling, further discussing current challenges and perspectives.

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A systematic review of 3-D printing in cardiovascular and cerebrovascular diseases

Cited by 44 publications

References 61 publications

A systematic review of clinical value of three-dimensional printing in renal disease

A systematic review of clinical value of three-dimensional printing in renal disease

Three‐dimensional printing in congenital heart disease: A systematic review

3D bioprinting for cardiovascular regeneration and pharmacology

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