A Systematic Review of Adherence-Enhancing Interventions in Adolescents Taking Long-term Medicines

Salema, Nde-Eshimuni; Elliott, Rachel A.; Glazebrook, Cris

doi:10.1016/j.jadohealth.2011.02.010

Cited by 45 publications

(38 citation statements)

References 54 publications

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“…Most of the key self-care evidence were published in the medical, nursing and psychology literature, as well as in Government policy papers. A scoping and synthesis of the key literature and government policy papers 3,8,13,19,20,45, identified from this narrative review process led to the development a single framework that brought together the core elements of self-care support of LTCs ( Fig. 1).…”

Section: Identifying the Core Elements Of Self-care Support Of Ltcsmentioning

confidence: 99%

“…Some of these skills include self-monitoring skills, 8 coping skills to deal with, and respond to changes in LTC signs and symptoms, 58 self-administration of certain medicines such as inhalers, 59 and adherence and ability to effectively use prescribed medicines. 45 …”

Section: Skills Training and Supportmentioning

confidence: 99%

“…8 However, there is very little published evidence in pharmacy practice. 43 The majority of the published work in pharmacy has focused on very specific aspects such as medication reviews, 36 medication management, 44 adherence to medications, 45 and diseasespecific interventions. 46 Self-care of LTCs by HCPs is however described as a much more multidimensional holistic concept that looks at how care is provided to the patient as a whole not as separate, single, disease-specific interventions.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A qualitative study exploring community pharmacists' awareness of, and contribution to, self-care support in the management of long-term conditions in the United Kingdom

Ogunbayo

Schafheutle

Cutts

et al. 2015

Research in Social and Administrative Pharmacy

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Section: Identifying the Core Elements Of Self-care Support Of Ltcsmentioning

confidence: 99%

Section: Skills Training and Supportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A qualitative study exploring community pharmacists' awareness of, and contribution to, self-care support in the management of long-term conditions in the United Kingdom

Ogunbayo

Schafheutle

Cutts

et al. 2015

Research in Social and Administrative Pharmacy

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“…Unfortunately, HIV incidence is highest in youth while medication adherence is also lowest in this population. 103,[108][109][110] The US-based Adolescent Trials Network (ATN) supported a study, ATN110, suggesting feasibility and safety in a PrEP study among young MSM aged 18-22 years as part of Project PrEPare; however, low adherence levels (63.4% detectable tenofovir at week 4 and 20% at week 24) confirmed that the most challenging aspect of this is sustained adherence. 111 In addition, adherence and effectiveness of PrEP was lowest among the Black adolescents in the trial, suggesting a potential need to reduce racial disparities in adherence rates.…”

mentioning

confidence: 99%

HIV incidence among gay men and other men who have sex with men in 2020: where is the epidemic heading?

et al. 2017

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Abstract. The goal to effectively prevent new HIV infections among gay, bisexual, and other men who have sex with men (MSM) is more challenging now than ever before. Despite declines in the late 1990s and early 2000s, HIV incidence among MSM is now increasing in many low-and high-income settings including the US, with young, adolescent, and racial/ethnic minority MSM being among those at highest risk. Potentiating HIV risks across all settings are individual-, network-, and structural-level factors such as stigma and lack of access to pre-exposure prophylaxis (PrEP) and antiretroviral treatment as prevention. To make a sustained impact on the epidemic, a concerted effort must integrate all evidence-based interventions that will most proximally decrease HIV acquisition and transmission risks, together with structural interventions that will support improved coverage and retention in care. Universal HIV treatment, increased access to HIV testing, and daily oral PrEP have emerged as integral to the prevention of HIV transmission, and such efforts should be immediately expanded for MSM and other populations disproportionately affected by HIV. Respect for human rights and efforts to combat stigma and improve access to prevention services are needed to change the trajectory of the HIV pandemic among MSM.

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“…[5][6][7] Adherence to medications, including PrEP, is known to be a significant challenge for adolescents and young adults. [8][9][10][11][12][13][14] In a recent study of PrEP use among 200 YMSM (mean age 20.2 years, 54.5% Black, 26.5% Latino), at week 4, 56% had protective levels of intracellular tenofovir-diphosphate (TFV-DP) (i.e., consistent with >4 pills/week). This decreased to 48% at week 24 and 34% at week 48.…”

Section: Introductionmentioning

confidence: 99%

Testing the Efficacy of a Social Networking Gamification App to Improve Pre-Exposure Prophylaxis Adherence (P3: Prepared, Protected, emPowered): Protocol for a Randomized Controlled Trial (Preprint)

LeGrand¹,

Knudtson²,

Benkeser³

et al. 2018

Preprint

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Background: HIV prevalence is high among young men who have sex with men (YMSM) and young transgender women who have sex with men (YTWSM), particularly among minorities. Despite its proven efficacy and safety, uptake of and adherence to pre-exposure prophylaxis (PrEP) among YMSM and YTWSM is currently limited. To date, evidencebased interventions to promote and sustain PrEP adherence have been limited and not shown to be highly efficacious. Given the widespread adoption of smartphones, mobile applications can be utilized to increase PrEP adherence for many YMSM and YTWSM. Objective:The study consists of a formative research phase to develop an app-based intervention, P3 (Prepared, Protected, emPowered), to increase PrEP adherence, and a randomized controlled trial (RCT) to test its efficacy. P3 is a mobile application built on an established health platform, which includes interactive social networking and game-based components to encourage PrEP adherence among YMSM and YTWSM. P3+ includes all P3 features plus adherence counseling delivered via two-way text messaging through the app. Methods:The formative research phase includes usability testing to assess users' comprehension of P3's educational content, understanding and use of intervention features, and overall impressions of app functionality, followed by app refinements. A subsequent field trial will identify and resolve any remaining technical challenges. A threearm RCT (P3, P3+, standard of care) will then be conducted at six iTech subject recruitment venues to assess intervention efficacy and to conduct a comparison of costs to deliver the two intervention arms.Results: This is an ongoing research project with initial results from the formative work expected in 2020 and RCT results in 2021.Conclusion: P3 features aim to provide an engaging, interactive approach that is highly appealing for the target population, leveraging technology already heavily integrated into the lives of young people, and will ensure that the users' needs are met in a familiar, stimulating way. If efficacious, P3 would be a sustainable, easily disseminated, lower-cost PrEP intervention for YMSM and YTWSM. Further, the research aims to determine the processes that are essential to developing and implementing future health-related gamification interventions.Trial Registration: ClinicalTrials.gov NCT03320512.Keywords: pre-exposure prophylaxis; gamification; young men who have sex with men; young transgender women who have sex with men; adherence; smartphone; applications (app); mHealth

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A Systematic Review of Adherence-Enhancing Interventions in Adolescents Taking Long-term Medicines

Cited by 45 publications

References 54 publications

A qualitative study exploring community pharmacists' awareness of, and contribution to, self-care support in the management of long-term conditions in the United Kingdom

A qualitative study exploring community pharmacists' awareness of, and contribution to, self-care support in the management of long-term conditions in the United Kingdom

HIV incidence among gay men and other men who have sex with men in 2020: where is the epidemic heading?

Testing the Efficacy of a Social Networking Gamification App to Improve Pre-Exposure Prophylaxis Adherence (P3: Prepared, Protected, emPowered): Protocol for a Randomized Controlled Trial (Preprint)

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