A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies

Jiménez-Labaig, Pablo; Rullan, Antonio; Hernando-Calvo, Alberto; Llop, Sandra; Bhide, Shreerang; O’Leary, Ben; Braña, Irene; Harrington, Kevin J.

doi:10.1016/j.ctrv.2024.102772

Cancer Treatment Reviews

2024

DOI: 10.1016/j.ctrv.2024.102772

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A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies

Pablo Jiménez-Labaig,

Antonio Rullan,

Alberto Hernando-Calvo

et al.

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2024

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Cited by 3 publications

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Unlocking the potential of bispecific ADCs for targeted cancer therapy

Zeng,

Ning,

Liu

et al. 2024

Front. Med.

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Unlocking the potential of bispecific ADCs for targeted cancer therapy

Zeng,

Ning,

Liu

et al. 2024

Front. Med.

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Salivary biomarkers: a promising approach for predicting immunotherapy response in head and neck cancers

Nejat Dehkordi,

Maddahi,

Vafa

et al. 2024

Clin Transl Oncol

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Tumor-related IGF2BP1-derived molecular subtypes to predict prognosis and immune microenvironment in head and neck squamous cell carcinoma

Ding,

Liu,

Pan

et al. 2024

Front. Immunol.

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BackgroundRecent studies have underscored the biological significance of RNA modifications in tumorigenicity and progression. However, the potential roles of RNA modifications in immune regulation and the formation of the tumor microenvironment (TME) in head and neck squamous carcinoma (HNSC) remain unclear.MethodsWe collected 199 untreated HNSC samples and clinicopathological data from Fujian Provincial Cancer Hospital. MeRIP-seq and RNA-seq were performed to generate methylation and gene expression profiles, respectively. Consensus molecular subtyping was employed to identify prognosis-related genes and RNA modification patterns in HNSC. Experiments confirmed the potential oncogenic behavior influenced by key genes. Molecular subtypes were identified through consensus clustering and validated using external cohort validation sets.ResultsAmong the RNA modification-related genes, IGF2BP1 emerged as the most prognostic. HNSC patients were categorized into high and low IGF2BP1 expression groups. High-expressing patients exhibited poorer survival and reduced chemosensitivity, coupled with increased tumor mutational burden, low PD-L1 expression, and limited immune cell infiltration, indicative of aggressive disease. Analysis revealed two distinct RNA modification patterns associated with IGF2BP1 expression: biosynthetically intense type (BIT) and oncogenically active type (OAT), each characterized by distinct clinical features, outcomes, and biological pathways. In an independent immunotherapy cohort, BIT patients displayed enhanced immune responses and sustained clinical benefits.ConclusionsThis study highlights the crucial link between RNA modification and TME diversity. Evaluating RNA modification in tumors improves our understanding of TME features and supports the development of effective immunotherapy strategies.

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A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies

Cited by 3 publications

References 82 publications

Unlocking the potential of bispecific ADCs for targeted cancer therapy

Unlocking the potential of bispecific ADCs for targeted cancer therapy

Salivary biomarkers: a promising approach for predicting immunotherapy response in head and neck cancers

Tumor-related IGF2BP1-derived molecular subtypes to predict prognosis and immune microenvironment in head and neck squamous cell carcinoma

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