A Systematic Review of Biocompatible Cardiopulmonary Bypass Circuits and Clinical Outcome

Risk factors for pre, intra, and postoperative hospital mortality in patients undergoing aortic surgery

“…Ranucci et al [21] suggest that a multifactorial approach seems better suited to meet the complex reactions that lead to inflammatory lesions and activation of the coagulation cascade during cardiac surgeries. Probably, the key issue is the thrombin formation which, simultaneously, is a marker of activation of the clotting cascade and a trigger for the reactions of endothelial base, including consumption of antithrombin and protein C, activation, platelet adhesion and aggregation, expression of molecules adhesion and leukocyte adhesion and activation.…”

ECMO Biocompatibility: Surface Coatings, Anticoagulation, and Coagulation Monitoring

“…With respect to inflammation, most studies demonstrate reduced inflammatory response, particularly in the interleukins, alternative complement pathway and polymorphonuclear cells, compared to controls and other coating systems [12,[20][21][22][23][24][25]26]. Meta-analyses of the benefits of heparin coating have consistently found improvements in transfusion requirements, arrhythmias, ventilator times, and lengths of stay in the hospital or ICUs when using heparin-coated circuits for cardiopulmonary bypass [17,27,28,29]. One important aspect of many of these studies has been that many have focused on short-term impacts of heparin coatings.…”

Revascularização do miocárdio minimamente invasiva videoassistida

“…However, since its presentation, over 40 years ago, few innovations have been added to this therapy. Off-pump myocardial revascularization surgeries have been proposed in order to minimize the deleterious effects of ECC such as hemodilution, blood contact with foreign surfaces and the air and, thus, decrease the inflammatory response, resulting in fewer coagulation disorders and minor dysfunction of the involved target organs [23][24][25][26] .…”