A systematic review of clinical studies on hereditary factors in pelvic organ prolapse

Lince, Sabrina L.; Kempen, Léon C van; Vierhout, Mark E.; Kluivers, Kirsten B.

doi:10.1007/s00192-012-1704-4

Cited by 89 publications

(48 citation statements)

References 48 publications

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“…For example, a meta-analysis of clinical studies on family history of POP calculated that the relative odds for POP among women with a genetic predisposition was of 2.58. 22 A meta-analysis provided moderate evidence of the genetic association for urinary symptoms in women, with certain genes having an odds ratio (OR) of 2.5 for OAB and 2.1 for SUI. 23 Although specific genetic predisposition has not been identified, a systematic review of genetic studies found that collagen type 3 alpha 1 was associated with POP (OR 4.79).…”

Section: Phase I: Predisposing Factors For Pelvic Floor Disordersmentioning

confidence: 99%

The Epidemiology of Pelvic Floor Disorders and Childbirth

Hallock

Handa²

2016

Obstetrics and Gynecology Clinics of North America

163

122

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SYNOPSIS Using a life span model, this article presents new scientific findings regarding risk factors for pelvic floor disorders (PFDs), with a focus on the role of childbirth in the development of single or multiple co-existing PFDs. Phase I of the life span model includes predisposing factors such as genetic predisposition and race. Phase II of the model includes inciting factors such as obstetric events. Prolapse, urinary incontinence (UI) and fecal incontinence (FI) are more common among vaginally parous women, although the impact of vaginal delivery on risk of FI is less dramatic than for prolapse and UI. Finally, Phase III includes intervening factors such as age and obesity. Both age and obesity are associated with prevalence of PFDs. The prevention and treatment of obesity is an important component to PFD prevention.

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Section: Phase I: Predisposing Factors For Pelvic Floor Disordersmentioning

confidence: 99%

The Epidemiology of Pelvic Floor Disorders and Childbirth

Hallock

Handa²

2016

Obstetrics and Gynecology Clinics of North America

163

122

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“…POP severely affects women’s quality of life in several ways. It has socioeconomic and health consequences, affecting overall health and sexual function 3. It has been a major gynecologic problem in developed and developing nations 4.…”

Section: Introductionmentioning

confidence: 99%

Determinants of pelvic organ prolapse among gynecologic patients in Bahir Dar, North West Ethiopia: a case–control study

Asresie¹,

Admassu²,

Setegn³

2016

IJWH

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IntroductionPelvic organ prolapse (POP) is a significant public health problem in developing countries including Ethiopia. However, less has been documented on risk factors of POP. Therefore, the aim of this study was to identify the determinants factors of POP.MethodsAn unmatched case–control study was conducted among gynecologic patients in Bahir Dar city, North West Ethiopia, from July to October 2014. A total of 370 women (selected from outpatient departments) were included in the study. Cases (clients with stage III or IV POP) and controls (who declared free of any stages of POP) were identified by physicians using the Pelvic Organ Prolapse Quantitative Examination tool. Data analysis was carried out by SPSS version 20.0. Descriptive, bivariate, and multivariable logistic regression analyses were performed. Statistical differences were considered at P<0.05, and the strength of association was assessed by odds ratio (OR) and respective confidence intervals (CIs).ResultsThis study revealed that determinants such as age of women (>40 years) (adjusted OR [AOR] =3.0 [95% CI: 1.59–5.89]), sphincter damage (AOR =8.1 [95% CI: 1.67–39.7]), family history of POP (AOR =4.9 [95% CI: 1.94–12.63]), parity (≥4) (AOR =4.5 [95% CI: 2.26–9.10]), nonattendance of formal education (AOR =4.3 [95% CI: 1.25–14.8]), carrying heavy objects (AOR =3.1 [95% CI: 1.56–6.30]), body mass index (BMI) <18.5 kg/m2 (AOR =3.1 [95% CI: 1.22–7.82]), and delivery assisted by nonhealth professionals (AOR =2.6 [95% CI: 1.24–5.56]) were significantly associated with POP.ConclusionIn our study, sphincter damage, family history of POP, being uneducated, having ≥4 vaginal deliveries, carrying heavy objects, BMI <18.5 kg/m2, age ≥40 years, and having delivery assisted by nonhealth professional were the independent determinants of POP. Therefore, skilled delivery, further promoting family planning and girls’ education, early pelvic floor assessment, and counseling on avoidance of carrying heavy objects are recommended.

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“…It is well recognized that POP clusters in families, giving credence to a hereditary contribution to the phenotype. 7, 8 Genetic contributions to POP are under investigation. 9, 10, 11 …”

Section: Introductionmentioning

confidence: 99%

Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17

Allen‐Brady

Cannon‐Albright

Farnham

et al. 2015

American Journal of Obstetrics and Gynecology

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Objective We conducted a genome-wide linkage analysis to identify pelvic organ prolapse (POP) predisposition genes using a resource of high-risk POP pedigrees. Study Design Cases are defined as women who reported bothersome symptoms of POP based on standardized symptom questions (Pelvic Floor Distress Inventory (PFDI), moderately or quite bothered), and/or received treatment for POP documented in medical records. Our complete pedigree resource contains 299 familial POP cases in 83 high-risk pedigrees. Genotype data were obtained from Illumina HumanHap550, 610Q, the Human1M-Duo, Human Omni1-Quad, or the Human Omni 2.5 platforms. A set of single nucleotide polymorphism (SNP) markers common to all platforms was identified and markers in high linkage disequilibrium were removed. We performed a genome-wide linkage analysis under general dominant and recessive models using a Markov Chain, Monte Carlo linkage analysis method implemented in MCLINK software. Because 70 individuals in 32 pedigrees were used in a previously published linkage analysis for a phenotype of POP requiring treatment/surgery, we also performed linkage only including the 225 newly recruited and genotyped cases in 61 pedigrees. Results Linkage analysis using our complete pedigree resource for the loosened criteria of bothersome POP showed evidence for significant genome-wide linkage on chromosome 10q24-26 (recessive model, max HLOD 3.4); suggestive evidence was identified on chromosomes 6, 17, and an additional region on chromosome 10. In the subset of only the newly recruited familial POP cases, significant evidence for genome-wide linkage was observed on chromosome 17q25 (recessive model, max HLOD 3.3), and suggestive evidence for linkage was observed on chromosomes 10 and 11. Neither analysis duplicated the previously published linkage evidence for the POP-requiring-treatment/surgery phenotype observed on chromosome 9. Conclusion While the etiology of this common condition is unknown, this study provides evidence that loci on chromosomes 10q and 17q may contribute to POP etiology.

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A systematic review of clinical studies on hereditary factors in pelvic organ prolapse

Cited by 89 publications

References 48 publications

The Epidemiology of Pelvic Floor Disorders and Childbirth

The Epidemiology of Pelvic Floor Disorders and Childbirth

Determinants of pelvic organ prolapse among gynecologic patients in Bahir Dar, North West Ethiopia: a case–control study

Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17

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A systematic review of clinical studies on hereditary factors in pelvic organ prolapse

Cited by 89 publications

References 48 publications

The Epidemiology of Pelvic Floor Disorders and Childbirth

The Epidemiology of Pelvic Floor Disorders and Childbirth

Determinants of pelvic organ prolapse among gynecologic patients in Bahir Dar, North West Ethiopia: a case&ndash;control study

Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17

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Determinants of pelvic organ prolapse among gynecologic patients in Bahir Dar, North West Ethiopia: a case–control study