A systematic review of clinical studies on electrical stimulation therapy for patients with neurogenic bowel dysfunction after spinal cord injury

Deng, Yuling; Dong, Yonghai; Liu, Yun; Zhang, Qiong; Guan, Xiaohui; Chen, Xiaodan; Meng, Long; Xu, Lei; Yan, Cheng

doi:10.1097/md.0000000000012778

Cited by 32 publications

(26 citation statements)

References 30 publications

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“…In addition to the disruption of neuronal pathways controlling micturition, nerves involved in gut regulation are usually affected after spinal trauma [193]. Loss of neuronal inputs from CNS results in neurogenic bowel that is characterized by situations of faecal incontinence and constipation, but has a major impact on patients' quality of life, requiring strict daily management [189,194].…”

Section: Spinal Cord Injury and Visceral Dysfunction: Are Ngf And Bdnmentioning

confidence: 99%

Partners in Crime: NGF and BDNF in Visceral Dysfunction

Coelho

Oliveira

Antunes-Lopes

et al. 2019

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: Neurotrophins (NTs), particularly Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), have attracted increasing attention in the context of visceral function for some years. Here, we examined the current literature and presented a thorough review of the subject. : After initial studies linking of NGF to cystitis, it is now well-established that this neurotrophin (NT) is a key modulator of bladder pathologies, including Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS. NGF is upregulated in bladder tissue and its blockade results in major improvements on urodynamic parameters and pain. Further studies expanded showed that NGF is also an intervenient in other visceral dysfunctions such as endometriosis and Irritable Bowel Syndrome (IBS). : More recently, BDNF was also shown to play an important role in the same visceral dysfunctions, suggesting that both NTs are determinant factors in visceral pathophysiological mechanisms. Manipulation of NGF and BDNF improves visceral function and reduce pain, suggesting that clinical modulation of these NTs may be important; however, much is still to be investigated before this step is taken. : Another active area of research is centered on urinary NGF and BDNF. Several studies show that both NTs can be found in the urine of patients with visceral dysfunction in much higher concentration than in healthy individuals, suggesting that they could be used as potential biomarkers. However, there are still technical difficulties to be overcome, including the lack of a large multicentre placebo-controlled studies to prove the relevance of urinary NTs as clinical biomarkers.

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Section: Spinal Cord Injury and Visceral Dysfunction: Are Ngf And Bdnmentioning

confidence: 99%

Partners in Crime: NGF and BDNF in Visceral Dysfunction

Coelho

Oliveira

Antunes-Lopes

et al. 2019

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“…Die Botox-Injektion bei spastischem Analsphinkter kommt nur für Patienten mit Läsionen des oberen motorischen Neurons infrage [ 15 ]. Bei Patienten mit inkompletter Lähmung könnte die Sakralnervenmodulation (SNM) dazu beitragen, neben der besser validierten Wirkung auf die Blasen- auch die Darmfunktion zu verbessern, wobei sich die Evidenz aus kleinen Fallserien begründet und dementsprechend keine klare Empfehlung ausgesprochen werden kann [ 10 , 20 ].…”

Section: Ergebnisseunclassified

Der querschnittgelähmte Patient – Besonderheiten der viszeralchirurgischen Diagnostik und Therapie

Seifert

Böthig

Wolter

et al. 2021

Chirurg

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Zusammenfassung Hintergrund Patienten mit einer Querschnittlähmung entwickeln syndromspezifische, viszeralchirurgisch relevante Krankheitsbilder, die im Rahmen des akuten spinalen Schocks auftreten können oder Folge der zumeist progredienten neurogenen Darmfunktionsstörung (NBD) mit Ausbildung eines Colon elongatum und/oder Megakolons sind. Auch die akuten abdominalchirurgischen Notfälle, wie akute Appendizitis, Cholezystitis, Divertikultis oder Ileusbilder, stellen den Kliniker bei untypischer oder teils fehlender Klinik vor diagnostische und therapeutische Herausforderungen. Einen zunehmenden Stellenwert nimmt die Ausweitung adipositaschirurgischer Indikationen auf Patienten mit einer Querschnittlähmung ein Ziel der Arbeit Dieser Artikel soll einen Überblick über die speziellen Anforderungen und Aspekte in der Behandlung dieses speziellen Patientenkollektivs geben und die Evidenz querschnittspezifischer viszeralchirurgischer Behandlungen aufzeigen. Material und Methoden Es wurde eine selektive Literaturrecherche in den Datenbanken Medline und Cochrane Library in deutscher und englischer Sprache (1985–2020) durchgeführt. Ergebnisse und Diskussion Die klinische Behandlung querschnittgelähmter Patienten erfordert einen profunden Kenntnisstand über die pathophysiologischen Veränderungen bei unterschiedlicher Querschnitthöhe (oberes vs. unteres motorisches Neuron) und die Phasen der Erkrankung (spinaler Schock vs. Langzeitverlauf). Fehlende oder atypische klinische Symptome akuter Erkrankungen verzögern eine rasche Diagnosefindung und machen eine frühzeitige Durchführung gezielter Diagnostik unabdingbar. Die Evidenz der chirurgischen Behandlung der akuten und chronischen Folgen der NBD ist gering und basiert auf Fallserien und „case reports“ ebenso wie die für spezielle Indikationen wie adipositaschirurgische Eingriffe.

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“…In clinical setting, electric stimulation has been used in different instances with mixed outcomes. Recent studies, for example, include the use of electric stimulation to treat neurogenic bowel dysfunction in patients that suffered spinal cord injuries, but without consistent results [131]. On the other hand, EF stimulation resulted in a reliable recovery of motor functions in patients experienced a stroke [132], an improvement in visual abilities by the placement skin electrodes in patients with retinitis pigmentosa [133] and accelerated wound healing [19], collectively indicating the potential of EF stimulation in reparative medicine.…”

Section: Electric Field Stimulation In Vitro and In Vivomentioning

confidence: 99%

Electric field stimulation for tissue engineering applications

2021

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Electric fields are involved in numerous physiological processes, including directional embryonic development and wound healing following injury. To study these processes in vitro and/or to harness electric field stimulation as a biophysical environmental cue for organised tissue engineering strategies various electric field stimulation systems have been developed. These systems are overall similar in design and have been shown to influence morphology, orientation, migration and phenotype of several different cell types. This review discusses different electric field stimulation setups and their effect on cell response.

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A systematic review of clinical studies on electrical stimulation therapy for patients with neurogenic bowel dysfunction after spinal cord injury

Abstract: Supplemental Digital Content is available in the text

Cited by 32 publications

References 30 publications

Partners in Crime: NGF and BDNF in Visceral Dysfunction

Partners in Crime: NGF and BDNF in Visceral Dysfunction

Der querschnittgelähmte Patient – Besonderheiten der viszeralchirurgischen Diagnostik und Therapie

Electric field stimulation for tissue engineering applications

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