“…On the financial front, the annual total cost of Semaglutide therapy was approximately five times higher than other antidiabetic regimens, translating to a significant extra expense of around $4200 USD per patient per year ( Laursen et al, 2023 ). The existing literature presents conflicting views on the cost-effectiveness of GLP-1 analogues compared to other hypoglycemic agents, largely due to variations in study methodology, choice of decision-analytical models, and potential sponsorship bias ( Laursen et al, 2023 ). Recent reviews and studies from other countries suggest that new hypoglycemic agents are cost-effective when added to metformin for managing uncontrolled T2DM, although SGLT2 inhibitors often emerge as the most economical option ( Zhu et al, 2023 , Chien et al, 2020 , Thomsen et al, 2022 , Wysham et al, 2018 , Poonawalla et al, 2021 ).…”