2024
DOI: 10.1111/cts.70020
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A systematic review of dexmedetomidine pharmacology in pediatric patients

Aislinn O'Kane,
Sara K. Quinney,
Emily Kinney
et al.

Abstract: Dexmedetomidine is a centrally acting alpha‐2 agonist used for initiation and maintenance of procedural sedation and mechanical ventilation in adult and pediatric settings. It is commonly used in both pediatric and neonatal intensive care units. Dexmedetomidine requires extensive titration, and patients can be over or under‐sedated during titration, leading to adverse events such as hypotension and bradycardia, or inadequate sedation, which can result in self‐extubation. There is a critical need to identify fa… Show more

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