A Systematic Review of Discrete Choice Experiment Studies in Rheumatoid Arthritis Biological Medicines

Abstract

Objective: Rheumatoid arthritis is a chronic disease with various clinical characteristics. The introduction of biological drugs has enhanced the efficacy and increased diversity of treatment options. Considering the patients’ preferences in decision-making about treatment can improve their adherence. A discrete choice experiment is a type of conjoint method that can elicit preferences in more realistic scenarios. This article reviewed discrete choice experiment (DCE) studies to extract which attributes and levels were included in surveys. In addition, we focused on the process of designing surveys and the method that they used. Method: PubMed, EMBASE, Web of Science, Scopus, Ovid (Medline) and ProQuest were systematically searched in order to find studies that evaluated rheumatoid arthritis patients’ preferences about biological medicines. Studies published in peer-reviewed journals between 1/1/1990 and 12/31/2019 were included. The included studies were analyzed using a narrative synthesis method and descriptive statistics. Results: A total of 7124 studies were initially found. After deleting irrelevant and duplicate studies, 15 studies were included. The most common attributes that were used in surveys were efficacy, adverse effect, route of administration, frequency of administration, and cost. Most studies used a literature review for developing attributes and levels. The median number of included attributes and levels were seven and three, respectively. Eight studies explained their experimental design while seven studies did not. Conditional logit and mixed logit were the most common methods for modeling reciprocally. Conclusion: Several aspects of DCE studies investigating biological drugs in RA were assessed. Explaining the sample size, experimental design, and qualitative work for developing attributes can improve this type of study.

Factors influencing choice of b/ts DMARDs in managing inflammatory arthritis from a patient perspective: a systematic review of global evidence and a patient-based survey from Hong Kong

“…This is the first study to propose a diagram for the decision-making process on b/ts DMARDs that potentially explains the dynamics of patients’ attitudes given the long-term treatment course for IA and the complicated trade-off between benefits and risks imposed on patients. This study also synthesised evidence from discrete choice event (DCE) studies which had only been explored in terms of methodology in conducting DCE in a prior systematic review 19…”

“…This study also synthesised evidence from discrete choice event (DCE) studies which had only been explored in terms of methodology in conducting DCE in a prior systematic review. 19 …”

“…Overview Two thousand two hundred and sixty-one studies were searched out of four databases, and 15 studies were added from the manual research of a systematic review. 19 After removing 466 duplications, 1713 irrelevant studies during abstract screening, and 63 other ineligible studies by inclusion/exclusion criteria, 34 papers were included and assessed for content analysis (initiation: N=4 [20][21][22][23] ; preference: N=8 [24][25][26][27][28][29][30][31] ; discontinuation: N=8 [32][33][34][35][36][37][38][39] ; initiation/preference: N=13 [40][41][42][43][44][45][46][47][48][49][50][51][52] ; initiation/discontinuation: N=1 53 ). The study selection flow diagram is shown in online supplemental figure 1.…”

Public Preferences and Willingness to Pay for a COVID-19 Vaccine in Iran: A Discrete Choice Experiment

“…The conditional logit is one of the common estimation models used for statistical analysis [21][22][23][24]. The selection set was estimated by a conditional logit regression model using Stata software.…”

Preferences for Rehabilitation in Persons with a History of Stroke: A Discrete Choice Experiment

“…There is an increasing need to investigate patient preferences in assessing the value of health, [18][19][20] and it would be meaningful to investigate the preferences of stroke patients for rehabilitation, which is an important need worldwide. In particular, stroke patients were considered to have a high need for outpatient rehabilitation to gain mobility and compensatory methods of activities of daily living even after discharge from the hospital.…”