A systematic review of experimental animal studies on microbial bioaerosols: Dose-response data for the derivation of exposure limits

Zamfir, Mihai; Gerstner, Doris; Walser, Sandra M.; Bünger, Jürgen; Eikmann, Thomas; Heinze, Stefanie; Kolk, Annette; Nowak, Dennis; Raulf, Monika; Sagunski, H.; Sedlmaier, Nadja; Suchenwirth, R; Wiesmüller, Gerhard Andreas; Wollin, Klaus‐Michael; Tesseraux, Irene; Herr, Caroline

doi:10.1016/j.ijheh.2018.11.004

Cited by 15 publications

(10 citation statements)

References 39 publications

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“…lease microorganisms along with plant debris into the atmosphere, strong air motions induce higher dispersion. These observations are in good agreement with those previously reported (Jones and Harrison, 2004;Liang et al, 2013;Zhang et al, 2010Zhang et al, , 2015Zhu et al, 2018b). For instance Liang et al (2013) have found a negative correlation between wind speed and polyol concentrations, and the highest atmospheric fungal spores concentrations were observed for a wind speed range of 0.6 to 1.0 m s −1 .…”

Section: Influence Of Meteorological Parameters On Ambient Concentratsupporting

confidence: 92%

“…Based on parallel measurements of spore counts and PM 10 polyol concentrations at three sites within the area of Vienna (Austria), Bauer et al (2008) found an average arabitol and mannitol content per fungal spores of, respectively, 1.2 pg per spore (range 0.8-1.8 pg per spore) and 1.7 pg per spore (range 1.2-2.4 pg per spore). Mannitol and arabitol have also often been identified in the green algae and lower plants Di Filippo et al, 2013;Gosselin et al, 2016;Vélëz et al, 2007;Xu et al, 2018;Zhang et al, 2010). Gosselin et al (2016) observed a relatively low (R 2 = 0.31) to high (R 2 = 0.84) coefficient of determination between mannitol and arabitol for total suspended particles (TSPs) collected at a pine-forested area during dry and rainy periods, respectively.…”

Section: Data Analysesmentioning

confidence: 99%

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Arabitol, mannitol, and glucose as tracers of primary biogenic organic aerosol: the influence of environmental factors on ambient air concentrations and spatial distribution over France

et al. 2019

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The primary sugar compounds (SCs, defined as glucose, arabitol, and mannitol) are widely recognized as suitable molecular markers to characterize and apportion primary biogenic organic aerosol emission sources. This work improves our understanding of the spatial behavior and distribution of these chemical species and evidences their major effective environmental drivers. We conducted a large study focusing on the daily (24 h) PM 10 SC concentrations for 16 increasing space scale sites (local to nationwide), over at least 1 complete year. These sites are distributed in several French geographic areas of different environmental conditions. Our analyses, mainly based on the examination of the short-term evolutions of SC concentrations, clearly show distance-dependent correlations. SC concentration evolutions are highly synchronous at an urban city scale and remain well correlated throughout the same geographic re-Published by Copernicus Publications on behalf of the European Geosciences Union. 11014A. Samaké et al.: Arabitol, mannitol, and glucose as tracers of primary biogenic organic aerosol gions, even if the sites are situated in different cities. However, sampling sites located in two distinct geographic areas are poorly correlated. Such a pattern indicates that the processes responsible for the evolution of the atmospheric SC concentrations present a spatial homogeneity over typical areas of at least tens of kilometers. Local phenomena, such as the resuspension of topsoil and associated microbiota, do no account for the major emissions processes of SC in urban areas not directly influenced by agricultural activities. The concentrations of SC and cellulose display remarkably synchronous temporal evolution cycles at an urban site in Grenoble, indicating a common source ascribed to vegetation. Additionally, higher concentrations of SC at another site located in a crop field region occur during each harvest periods, indicating resuspension processes of plant materials (crop detritus, leaf debris) and associated microbiota for agricultural and nearby urbanized areas. Finally, ambient air temperature, relative humidity, and vegetation density constitute the main effective drivers of SC atmospheric concentrations.

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Section: Influence Of Meteorological Parameters On Ambient Concentratsupporting

confidence: 92%

Section: Data Analysesmentioning

confidence: 99%

Arabitol, mannitol, and glucose as tracers of primary biogenic organic aerosol: the influence of environmental factors on ambient air concentrations and spatial distribution over France

et al. 2019

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“…Phys., 19, 11013-11030, 2019 at three sites within the area of Vienna (Austria), Bauer et al (2008) found an average arabitol and mannitol content per fungal spores of, respectively, 1.2 pg per spore (range 0.8-1.8 pg per spore) and 1.7 pg per spore (range 1.2-2.4 pg per spore). Mannitol and arabitol have also often been identified in the green algae and lower plants (Buiarelli et al, 2013;Di Filippo et al, 2013;Gosselin et al, 2016;Vélëz et al, 2007;Xu et al, 2018;Zhang et al, 2010). Gosselin et al (2016) observed a relatively low (R 2 = 0.31) to high (R 2 = 0.84) coefficient of determination between mannitol and arabitol for total suspended particles (TSPs) collected at a pine-forested area during dry and rainy periods, respectively.…”

Section: Data Analysesmentioning

confidence: 99%

Answer to referee #1

SAMAKE¹

2019

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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“…Although some microbial species, such as bacteria, are suspected to have a protective effect against asthma development and exacerbation, it is not the case for mold exposure [12]. Inflammatory effects of fungal bioaerosols were also observed in experimental animal studies [13].…”

Section: Introductionmentioning

confidence: 99%

Relationships between Exposure to Bioaerosols, Moldy Surface and Symptoms in French Mold-Damaged Homes

et al. 2020

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Air quality in homes is a major concern in Europe, where people spend most of their time indoors. According to the World Health Organization, numerous houses are subject to dampness that can lead to mold growth, with associated health and economic consequences. Our goal was to characterize the human exposure to bioaerosols in French mold-damaged houses but also to study the effects of these bioaerosols as suffered by the inhabitants of these houses. A global approach including both field study and laboratory experimentation was used to investigate 48 mold-damaged homes. Among a wide fungal diversity, 101 viable species, Aspergillus versicolor, Penicillium chrysogenum and P. crustosum were observed as recurrent species and could be used as microbial indicators of indoor air quality. Statistical analyses highlighted a relationship between the concentrations of these recurrent molds and the levels of surface contamination by molds in homes. Fever, cough, dyspnea, flu-like symptoms were observed with several fungal strains (A. versicolor, P. chrysogenum and P. crustosum) or in relation to moldy odor. Relationships between particles of 2 to 15 µm diameter and headaches and dizziness were also observed. In our study, we identified a cutaneous effect (itching) in relationship to the airborne concentration of A. versicolor.

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A systematic review of experimental animal studies on microbial bioaerosols: Dose-response data for the derivation of exposure limits

Cited by 15 publications

References 39 publications

Arabitol, mannitol, and glucose as tracers of primary biogenic organic aerosol: the influence of environmental factors on ambient air concentrations and spatial distribution over France

Arabitol, mannitol, and glucose as tracers of primary biogenic organic aerosol: the influence of environmental factors on ambient air concentrations and spatial distribution over France

Answer to referee #1

Relationships between Exposure to Bioaerosols, Moldy Surface and Symptoms in French Mold-Damaged Homes

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