A systematic review of health state utility values for thyroid cancer

Abstract

Purpose Health state utility values are commonly used to inform economic evaluations and determine the cost-effectiveness of an intervention. The aim of this systematic review is to summarise the utility values available to represent the health-related quality of life (HRQoL) of patients with thyroid cancer. Methods Eight electronic databases were searched from January 1999 to April 2019 for studies which included assessment of HRQoL for patients with thyroid cancer. Utility estimates derived from multiple sources (EuroQol questionnaire 5-dimension (EQ-5D), time trade-off [TTO] and standard gamble [SG] methods) were extracted. In addition, utility estimates were generated by mapping from SF-36 and EORTC QLQ-30 to the EQ-5D-3L UK value set using published mapping algorithms. Results Searches identified 33 eligible studies. Twenty-six studies reported HRQoL for patients with differentiated thyroid cancer and seven studies for patients with general thyroid cancer. We identified studies which used different methods and tools to quantify the HRQoL in patients with thyroid cancer, such as the EQ-5D-3L, SF-36, EORTC QLQ-30 and SG and TTO techniques to estimate utility values. Utility estimates range from 0.205 (patients with low-risk differentiated thyroid cancer) to utility values approximate to the average UK population (following successful thyroidectomy surgery and radioiodine treatment). Utility estimates for different health states, across thyroid cancer sub-types and interventions are presented. Conclusion A catalogue of utility values is provided for use when carrying out economic modelling of thyroid cancer; by including mapped values, this approach broadens the scope of health states that can be considered within cost-effectiveness modelling.

WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

“…The reason might due to the rapid development of imaging detection technologies and increasing awareness of people's health [3] , especially considering that thyroid cancer mortality remained stable at a rate of approximately 0.5 cases per 100000 persons [4] . Thyroid cancers are divided into four main sub-types(papillary, follicular, medullary, and undifferentiated cancers) [5] .To date, the mechanism of thyroid carcinogenesis remains incompletely understood, and the only well-established risk factor for thyroid cancer might be exposure to ionizing radiation [6] . DNA damaging which caused by ionizing radiation may lead to mutations, genomic instability.…”

Time trade-off health state utility values for depression: a systematic review and meta-analysis

“…Remarkable differences between various methods of utility generation have been reported [65][66][67]. Nine of the included studies used methods other than TTO to elicit utilities pertaining to the same health state.…”

Cost-Utility Analysis of Early Detection with Ultrasonography of Differentiated Thyroid Cancer: A Retrospective Study on a Korean Population

“…The input data used in the model are summarized in Table 1 [6,9,12,18,24,26,29,[34][35][36][37][38][39][40][41][42][43]. Only direct medical costs were considered for cost estimation.…”