A Systematic Review of Host Genomic Variation and Neuropsychological Outcomes for Pediatric Cancer Survivors

Kautiainen, Rella J.; Aleksonis, Holly A.; King, Tricia Z.

doi:10.1007/s11065-022-09539-2

Cited by 4 publications

(2 citation statements)

References 85 publications

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“…Capturing these measures at the time of other medically necessary blood panel monitoring may help reduce overall burden on the patients as science better understands the benefits of different and plausibly complementary biomarkers. Furthermore, future studies should consider homogeneity of samples to provide greater precision in characterizing individual contributors to outcomes including tumor location (e.g., cerebellum; Clark et al, 2021), tumor genetics (e.g., Northcott et al, 2019) and host genetics (Kautianen et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

A systematic review of pediatric neuropsychological outcomes with proton versus photon radiation therapy: A call for equity in access to treatment

Peterson

King

2022

J Int Neuropsychol Soc

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Objective: There is increasing interest in the utilization of proton beam radiation therapy (PRT) to treat pediatric brain tumors based upon presumed advantages over traditional photon radiation therapy (XRT). PRT provides more conformal radiation to the tumor with reduced dose to healthy brain parenchyma. Less radiation exposure to brain tissue beyond the tumor is thought to reduce neuropsychological sequelae. This systematic review aimed to provide an overview of published studies comparing neuropsychological outcomes between PRT and XRT. Method: PubMed, PsychINFO, Embase, Web of Science, Scopus, and Cochrane were systematically searched for peer-reviewed published studies that compared neuropsychological outcomes between PRT and XRT in pediatric brain tumor patients. Results: Eight studies were included. Six of the studies utilized retrospective neuropsychological data; the majority were longitudinal studies (n = 5). XRT was found to result in lower neuropsychological functioning across time. PRT was associated with generally stable neuropsychological functioning across time, with the exception of working memory and processing speed, which showed variable outcomes across studies. However, studies inconsistently included or considered medical and sociodemographic differences between treatment groups, which may have impacted neuropsychological outcomes. Conclusions: Despite methodological limitations, including limited baseline neuropsychological evaluations, temporal variability between radiation treatment and first evaluation or initial and follow-up evaluations, and heterogenous samples, there is emerging evidence of sociodemographic inequities in access to PRT. With more institutions dedicating funding towards PRT, there may be the opportunity to objectively evaluate the neuropsychological benefits of patients matched on medical and sociodemographic variables.

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Section: Discussionmentioning

confidence: 99%

A systematic review of pediatric neuropsychological outcomes with proton versus photon radiation therapy: A call for equity in access to treatment

Peterson

King

2022

J Int Neuropsychol Soc

View full text Add to dashboard Cite

show abstract

“…protocol. Research on outcomes due to host genome single-nucleotide polymorphisms (SNPs) is beginning to emerge (Kautiainen, Aleksonis, & King, 2022). For example, in the general population, individuals who are carriers of an at-risk allele have been found to perform more poorly on cognitive tests.…”

Section: Accepted Sciencementioning

confidence: 99%