A systematic review of influenza virus in water environments across human, poultry, and wild bird habitats

Kenmoe, S; Takuissu, GR; Ebogo-Belobo, JT; Kengne-Ndé, C; Mbaga, DS; Bowo-Ngandji, A; Ondigui Ndzie, JL; Kenfack-Momo, R; Tchatchouang, S; Lontuo Fogang, R; Zeuko'o Menkem, E; Kame-Ngasse, GI; Magoudjou-Pekam, JN; Puzelli, S; Lucentini, L; Veneri, C; Mancini, P; Bonanno Ferraro, G; Iaconelli, M; Del Giudice, C; Brandtner, D; Suffredini, E; La Rosa, G

doi:10.1016/j.wroa.2023.100210

Cited by 6 publications

(1 citation statement)

References 74 publications

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“…Influenza viruses are known for their global distribution and high infection rate among high-risk groups, resulting in a strong recommendation for vaccination in this subset of the population [1][2][3]. Some influenza strains can be zoonotic and transmitted to people [4].…”

Section: Introductionmentioning

confidence: 99%

A Computationally Optimized Broadly Reactive Hemagglutinin and Neuraminidase Vaccine Boosts Antibody-Secreting Cells and Induces a Robust Serological Response, Preventing Lung Damage in a Pre-Immune Model

Ge,

Mota,

Richardson

et al. 2024

Vaccines

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The hemagglutinin (HA) and neuraminidase (NA) surface proteins are the primary and secondary immune targets for most influenza vaccines. In this study, H2, H5, H7, N1, and N2 antigens designed by the computationally optimized broadly reactive antigen (COBRA) methodology were incorporated into an adjuvant-formulated vaccine to assess the protective efficacy and immune response against A/Hong Kong/125/2017 H7N9 virus challenge in pre-immune mice. The elicited antibodies bound to H2, H5, H7, N1, and N2 wild-type antigens; cH6/1 antigens; and cH7/3 antigens, with hemagglutinin inhibition (HAI) activity against broad panels of the H2Nx, H5Nx, and H7Nx influenza strains. Mice vaccinated with the pentavalent COBRA HA/NA vaccine showed little to no weight loss, no clinical signs of diseases, and were protected from mortality when challenged with the lethal H7N9 virus. Virus titers in the lungs of vaccinated mice were lower and cleared more rapidly than in mock-vaccinated mice. Some vaccinated mice showed no detectable lung injury or inflammation. Antibody-secreting cells were significantly increased in COBRA-vaccinated mice, with higher total Ig and H7-specific ASC. Thus, the combination of H2, H5, H7, N1, and N2 COBRA antigens presents a potential for the formulation of a universal influenza virus vaccine.

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Section: Introductionmentioning

confidence: 99%

A Computationally Optimized Broadly Reactive Hemagglutinin and Neuraminidase Vaccine Boosts Antibody-Secreting Cells and Induces a Robust Serological Response, Preventing Lung Damage in a Pre-Immune Model

Ge,

Mota,

Richardson

et al. 2024

Vaccines

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Evaluation of Trends in Influenza A and B Viruses in Wastewater and Human Surveillance Data: Insights from the 2022–2023 Season in Italy

Mancini,

Brandtner,

Veneri

et al. 2024

Food Environ Virol

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Wastewater-based epidemiology (WBE) is a recognized, dynamic approach to monitoring the transmission of pathogens in communities through urban wastewater. This study aimed to detect and quantify influenza A and B viruses in Italian wastewater during the 2022–2023 season (October 2022 to April 2023). A total of 298 wastewater samples were collected from 67 wastewater treatment plants (WTPs) across the country. These samples were analyzed for influenza A and B viruses (IAV, IBV) using primers originally developed by the Centers for Disease Control and Prevention (CDC) for real-time PCR and adapted for digital PCR. The overall detection rates of IAV and IBV across the entire study period were 19.1% and 16.8%, respectively. The prevalence of IAV in wastewater showed a gradual increase from October to December 2022, peaking at 61% in December. In contrast, IBV peaked at 36% in February 2023. This temporal discrepancy in peak concentrations suggests different seasonal patterns for the two influenza types. These trends mirrored human surveillance data, which showed influenza A cases peaking at 46% in late December and declining to around 2% by April 2023, and influenza B cases starting to increase significantly in January 2023 and peaking at about 14% in March. IAV concentrations ranged from 9.80 × 10 2 to 1.94 × 10 5 g.c./L, while IBV concentrations ranged from 1.07 × 10 3 to 1.43 × 10 4 g.c./L. Overall, the environmental data were consistent with the human surveillance trends observed during the study period in the country. These results demonstrate the value of WBE in tracking epidemiological patterns and highlight its potential as a complementary tool to infectious diseases surveillance systems. Supplementary Information The online version contains supplementary material available at 10.1007/s12560-024-09622-2.

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Tissue-resident memory T cells in protective immunity to influenza virus

Lee,

Yeung,

Watts

2024

Current Opinion in Virology

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A systematic review of influenza virus in water environments across human, poultry, and wild bird habitats

Cited by 6 publications

References 74 publications

A Computationally Optimized Broadly Reactive Hemagglutinin and Neuraminidase Vaccine Boosts Antibody-Secreting Cells and Induces a Robust Serological Response, Preventing Lung Damage in a Pre-Immune Model

A Computationally Optimized Broadly Reactive Hemagglutinin and Neuraminidase Vaccine Boosts Antibody-Secreting Cells and Induces a Robust Serological Response, Preventing Lung Damage in a Pre-Immune Model

Evaluation of Trends in Influenza A and B Viruses in Wastewater and Human Surveillance Data: Insights from the 2022–2023 Season in Italy

Tissue-resident memory T cells in protective immunity to influenza virus

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