A Systematic Review of MicroRNA Signatures Associated with the Progression of Leukoplakia with and without Epithelial Dysplasia

Kaunein, Nadia; Ramani, Rishi Sanjay; Koo, Kendrick; Moore, Caroline B.; Celentano, Antonio; McCullough, Michael; Yap, Tami

doi:10.3390/biom11121879

Cited by 6 publications

(2 citation statements)

References 50 publications

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“…De acordo com Kaunein (2021), a desregulação de miRNAs foi relatada em muitos tipos de câncer e demonstrou desempenhar um papel fundamental na iniciação, progressão, invasão e ativação da metástase da doença. No Carcinoma de Células Escamosas Oral (CECO), os microRNAs têm sido implicados na tumorigênese com a identificação de diferentes padrões de expressão dessas moléculas, o que permite caracterizar a massa neoplásica em sua fase inicial, embora alguns microRNAs possam se diferenciar independentemente entre lesões progressivas e não progressivas.…”

Section: Desenvolvimentounclassified

Diagnóstico de câncer oral através de biomarcadores, uma proposta não invasiva

Tifany Lima Silva,

Alves Nicolau,

Simone Pereira Domingos Moreira

et al. 2024

ISJHR

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The present study aimed to identify, through scientific literature, the use of biomarkers that help in the diagnosis of cancer in the oral cavity. This is a narrative review study with a qualitative and descriptive approach. To investigate the data, the databases of Periódicos Capes, PubMed and Sciencedirect were used, on the use of scientific articles, published during the time frame from 2019 to 2023, in Portuguese, English and Spanish, available online and free of charge, with expanded summary and in full text format. After applying filters, selecting descriptors and including review studies, meta-analysis, controlled and randomized tests, 52 articles were identified, among which 27 were from PubMed, 14 from Periódicos Capes and 11 from Science direct, in addition considering suitability, only 17 articles were registered for review. In this important study, it became evident that despite advances in the identification of tumor markers, they still do not have sufficient capacity to diagnose cancer in the oral cavity. However, it highlights its influence as an important tool for the prognosis of clinical conditions. Furthermore, it appears as a less invasive alternative, with more accessible samples such as saliva and promising results.

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Section: Desenvolvimentounclassified

Diagnóstico de câncer oral através de biomarcadores, uma proposta não invasiva

Tifany Lima Silva,

Alves Nicolau,

Simone Pereira Domingos Moreira

et al. 2024

ISJHR

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“…It is worth noting that the differentially expressed miRNAs in OLK are identified to associate with its malignant transformation [ 63 – 66 ]. In the latest scoping review, the authors have included fifteen articles for analysis and identified 21 differentially expressed miRNAs in OLK [ 67 ].…”

Section: The Evs-borne Cargo Are Changed By Cs Exposurementioning

confidence: 99%

The potential roles of cigarette smoke-induced extracellular vesicles in oral leukoplakia

et al. 2023

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Background The onset of oral leukoplakia (OLK), the most common oral lesion with a high risk of malignant transformation, is closely associated with the exposure of cigarette smoke. Cigarette smoke is a complicated mixture of more than 4500 different chemicals including various oxidants and free radical, which contributes to the onset of immune and inflammatory response or even carcinogenesis. Recent studies have proved that the exposure of cigarette smoke leads to the onset and aggravation of many diseases via significantly changed the production and components of extracellular vesicles. The extracellular vesicles are membrane-enclosed nanosized particles secreted by diverse cells and involved in cell–cell communication because of their ability to deliver a number of bioactive molecules including proteins, lipids, DNAs and RNAs. Getting insight into the mechanisms of extracellular vesicles in regulating OLK upon cigarette smoke stimulation contributes to unravel the pathophysiology of OLK in-depth. However, evidence done on the role of extracellular vesicles in cigarette smoke-induced OLK is still in its infancy. Materials and methods Relevant literatures on cigarette smoke, oral leukoplakia and extracellular vesicles were searched in PubMed database. Conclusions In this review, we summarize the recent findings about the function of extracellular vesicles in the pathogenesis of cigarette smoke-induced diseases, and to infer their potential utilizations as diagnostic biomarkers, prognostic evaluation, and therapeutic targets of OLK in the future.

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