2021
DOI: 10.1007/s00429-021-02397-3
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A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia

Abstract: Brain structural features of healthy individuals are associated with olfactory functions. However, due to the pathophysiological differences, congenital and acquired anosmia may exhibit different structural characteristics. A systematic review was undertaken to compare brain structural features between patients with congenital and acquired anosmia. A systematic search was conducted using PubMed/MEDLINE and Scopus electronic databases to identify eligible reports on anosmia and structural changes and reported a… Show more

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Cited by 31 publications
(18 citation statements)
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References 106 publications
(216 reference statements)
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“…neurons, the olfactory bulbs and adjacent brain parenchyma is a possible route of CNS entry for the virus 8 . Furthermore, similar brain regions are involved in congenital and other acquired anosmias 9 , supporting the hypothe sis that anterograde degeneration starts in the olfactory neurons or as a result of olfactory deprivation. Interestingly, olfactory symptoms are also considered as early warning signs in some neurodegenerative disorders.…”
Section: Stéphane Kremer and H Rolf Jägersupporting
confidence: 67%
“…neurons, the olfactory bulbs and adjacent brain parenchyma is a possible route of CNS entry for the virus 8 . Furthermore, similar brain regions are involved in congenital and other acquired anosmias 9 , supporting the hypothe sis that anterograde degeneration starts in the olfactory neurons or as a result of olfactory deprivation. Interestingly, olfactory symptoms are also considered as early warning signs in some neurodegenerative disorders.…”
Section: Stéphane Kremer and H Rolf Jägersupporting
confidence: 67%
“…The changes in the whole‐brain level were mainly explored by voxel‐based morphometry (VBM), which is a well‐established technique to detect the between‐group differences of the gray matter structures (Mechelli et al, 2005). A recent systematic review (Manan et al, 2022) summarized that the gray matter volumes were reduced in the gyrus rectus, medial orbitofrontal cortex, anterior cingulate cortex, insula, and cerebellum in acquired anosmia (Bitter, Brüderle, et al, 2010; Bitter, Gudziol, et al, 2010; Han et al, 2018; Peng et al, 2013; Yao et al, 2014). In addition, the duration of anosmia was positively associated with the degrees of GM atrophy in the limbic areas, as well as the dorsolateral prefrontal cortex (Bitter, Brüderle, et al, 2010; Bitter, Gudziol, et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Two independent researchers conducted a systematic search using the National Centre for Biotechnology Information (PubMed) and Scopus electronic databases. The preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) were used as the reporting guidelines [12] (Supplementary Materials Tables S1 and S2) and followed previous studies [13][14][15][16][17][18]. The search was performed to identify studies reporting diffusion tensor imaging, brain tumors, and preoperative mapping.…”
Section: Search Strategy and Study Selectionmentioning
confidence: 99%