A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications

Wang, Qirou; Wang, Jia; Li, Nannan; Liu, Junyu; Zhou, Jie; Zhuang, Pengwei; Chen, Hạixia

doi:10.3390/molecules27020444

Cited by 22 publications

(11 citation statements)

References 138 publications

(179 reference statements)

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“…On the other hand, the high dose of O. aristatus was able to reduce the HOMA-IR value to 1.70 ± 0.463, indicating a significant reverse in the insulin resistance condition. This result is in line with several previous studies that have proposed O. aristatus as an alternative treatment for type 2 diabetes [ 11 , 29 , 37 ].…”

Section: Discussionsupporting

confidence: 93%

“…This broad spectrum of benefits is attributed to the rich phenolic content, including polyphenols, diterpenes, triterpenes, lipophilic flavones, glycosides and caffeic acid derivatives such as rosmarinic acid (RA) [ 9 , 10 ]. O. aristatus is reported to have α-amylase and β-glucosidase inhibitory activities, exhibits antioxidant and anti-inflammatory properties, regulates lipid metabolism, promotes insulin secretion, improves insulin resistance, increases glucose uptake, promotes glycolysis and inhibits gluconeogenesis [ 11 ]. More importantly, a previous study provides evidence for the anti-obesity effect of O. aristatus through the inhibition of pancreatic lipase [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

et al. 2023

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Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of liver disease. Orthosiphon aristatus (Blume) Miq, a traditional plant in South Asia, has previously been shown to attenuate obesity and hyperglycaemic conditions. Eight weeks of feeding C57BL/6 mice with the standardized O. aristatus extract (400 mg/kg) inhibited the progression of NAFLD. Liver enzymes including alanine aminotransferase and aspartate transaminase were significantly reduced in treated mice by 74.2% ± 7.69 and 52.8% ± 7.83, respectively. Furthermore, the treated mice showed a reduction in serum levels of glucose (50% ± 5.71), insulin (70.2% ± 12.09), total cholesterol (27.5% ± 15.93), triglycerides (63.2% ± 16.5), low-density lipoprotein (62.5% ± 4.93) and atherogenic risk index relative to the negative control. Histologically, O. aristatus reversed hepatic fat accumulation and reduced NAFLD severity. Notably, our results showed the antioxidant activity of O. aristatus via increased superoxide dismutase activity and a reduction of hepatic malondialdehyde levels. In addition, the levels of serum pro-inflammatory mediators (IL-6 and TNFα) decreased, indicating anti-inflammatory activity. The aqueous, hydroethanolic and ethanolic fractions of O. aristatus extract significantly reduced intracellular fat accumulation in HepG2 cells that were treated with palmitic–oleic acid. Together, these findings suggest that antioxidant activities are the primary mechanism of action of O. aristatus underlying the anti-NAFLD effects.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

et al. 2023

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“…The 2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (7.12%) is also found as one of the major compositions, reported for effective inhibition of colon cancer cell growth (Ban et al 2007 ) and antioxidant activity (Chen et al 2021 ). In addition, vanillic acid (4-hydroxy-3-methoxy benzoic acid) is a phenolic derivative from plants known to possess anti-filarial, antibacterial, antioxidant, and anti-diabetic (Vinothiya and Ashokkumar 2017 ; Wang et al 2022 ), etc. Previous studies demonstrated maltol’s effectiveness against oxidative damage (Song et al 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant activity and α-glucosidase inhibitability of Distichochlamys citrea M.F. Newman rhizome fractionated extracts: in vitro and in silico screenings

et al. 2022

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Distichochlamys citrea M.F. Newman (commonly known as “Black Ginger”) is an endemic plant to Vietnam and has been extensively exploited by folk medication for treatments of infection-related diseases and diabetes. In this work, its rhizomes were subjected to fractionated extraction, phytochemical examination, evaluation of antioxidant effect by DDPH free radical neutralization, and inhibitory activity toward α -glucosidase. The compositional components were subjected to in silico screening, including density functional theory calculation, molecular docking simulation, physicochemical analysis, and pharmacokinetic regression. In the trials, EtOAc fraction is found as the bioactive part of most effectiveness, regarding both antioxidant effect (IC 50 = 90.27 µg mL −1 ) and α -glucosidase inhibitory activity (IC 50 = 115.75 μg mL −1 ). Chemical determination reveals there are 13 components of its composition. DFT-based calculations find no abnormal constraints in their structures. Docking-based simulation provides order of inhibitory effectiveness: 3-P53341 > 12-P53341 > 7-P53341 > 4-P53341 > 11-P53341 > 10-P53341 . QSARIS-based investigations implicate their biocompatibility. ADMET-based regressions indicate that all candidates are generally safe for medicinal applications. The findings would contribute to the basis for further studies on the chemical compositions of Distichochlamys citrea and their biological activities. Supplementary Information The online version contains supplementary material available at 10.1007/s11696-022-02273-2.

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“…Orthosiphon stamineus Benth. (Lamiaceae) is a perennial herb found in tropical and subtropical regions [ 7 ]. O. stamineus is used in folk medicine as an antidiabetic and diuretic and for treating abdominal pain, kidney and bladder inflammation, edema, and gout [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

In Vivo and In Vitro Antidiabetic Efficacy of Aqueous and Methanolic Extracts of Orthosiphon Stamineus Benth

et al. 2023

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Orthosiphon stamineus is a popular folk herb used to treat diabetes and some other disorders. Previous studies have shown that O. stamineus extracts were able to balance blood glucose levels in diabetic rat animal models. However, the antidiabetic mechanism of O. stamineus is not fully known. This study was carried out to test the chemical composition, cytotoxicity, and antidiabetic activity of O. stamineus (aerial) methanol and water extracts. GC/MS phytochemical analysis of O. stamineus methanol and water extracts revealed 52 and 41 compounds, respectively. Ten active compounds are strong antidiabetic candidates. Oral treatment of diabetic mice with O. stamineus extracts for 3 weeks resulted significant reductions in blood glucose levels from 359 ± 7 mg/dL in diabetic non-treated mice to 164 ± 2 mg/dL and 174 ± 3 mg/dL in water- and methanol-based-extract-treated mice, respectively. The efficacy of O. stamineus extracts in augmenting glucose transporter-4 (GLUT4) translocation to the plasma membrane (PM) was tested in a rat muscle cell line stably expressing myc-tagged GLUT4 (L6-GLUT4myc) using enzyme-linked immunosorbent assay. The methanol extract was more efficient in enhancing GLUT4 translocation to the PM. It increased GLUT4 translocation at 250 µg/mL to 279 ± 15% and 351 ± 20% in the absence and presence of insulin, respectively. The same concentration of water extract enhanced GLUT4 translocation to 142 ± 2.5% and 165 ± 5% in the absence and presence of insulin, respectively. The methanol and water extracts were safe up to 250 µg/mL as measured with a Methylthiazol Tetrazolium (MTT) cytotoxic assay. The extracts exhibited antioxidant activity as measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. O. stamineus methanol extract reached the maximal inhibition of 77 ± 10% at 500 µg/mL, and O. stamineus water extract led to 59 ± 3% inhibition at the same concentration. These findings indicate that O. stamineus possesses antidiabetic activity in part by scavenging the oxidants and enhancing GLUT4 translocation to the PM in skeletal muscle.

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A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications

Cited by 22 publications

References 138 publications

Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

Antioxidant activity and α-glucosidase inhibitability of Distichochlamys citrea M.F. Newman rhizome fractionated extracts: in vitro and in silico screenings

In Vivo and In Vitro Antidiabetic Efficacy of Aqueous and Methanolic Extracts of Orthosiphon Stamineus Benth

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