A systematic review of pharmacogenetic testing in primary care: Attitudes of patients, general practitioners, and pharmacists

Hansen, Johanne Mølby; Nørgaard, Josefine D.S.V.; Sporrong, Sofia Kälvemark

doi:10.1016/j.sapharm.2021.12.002

Cited by 14 publications

(31 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, use of highthroughput analysis machines on a larger scale and in clinical settings, together with powerful decision-making software may soon enable healthcare providers to use pharmacogenomics in drug-related decision-making on a regular basis (Gammal et al, 2019). Genetic variations are at the base of interindividual variability in drug response, that may result in adverse drug reactions or lack of drug efficacy (Hansen et al, 2021). Adverse drug reactions (ADRs) may cause discomfort, lower the quality of life and alter medication adherence, or even worse, cause hospital admission, morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Nation-Wide Survey Assessing the Knowledge and Attitudes of Romanian Pharmacists Concerning Pharmacogenetics

et al. 2022

View full text Add to dashboard Cite

Background: Pharmacogenetics (PGx) is an important component of personalized medicine that has the potential to improve medicines’ effectiveness and safety. However, despite progress in technology and availability, PGx testing application into patient-care in Eastern Europe countries, has been slow.Objectives: Our aim was to describe knowledge and attitudes of Romanian pharmacists concerning PGx, and identify potential factors limiting PGx implementation.Method: An anonymous, web-based questionnaire was distributed to Romanian pharmacists registered in the National Pharmacists’ Association (NPA) via an official e-mail sent by NPA representatives.Results: A total of 1,058 pharmacists completed the questionnaires, resulting in a response rate of 7.6%. Pharmacists were predominantly female (90.1%), younger than 49 years (87.5%) and mostly worked in community pharmacies (80.2%). Most pharmacists (64.8%) had a knowledge score between 30 and 49 points out of 60, and (75.4%) had attitude scores between 9 and 7 out of 10. Attitude and knowledge scores positively correlated.Conclusion: Despite performing fairly well on general questions regarding PGx, Romanian pharmacists may lack in-depth knowledge, which can affect their readiness to discuss PGx information with patients or other healthcare professionals. High pricing was considered an important impediment in PGx implementation.

show abstract

Section: Introductionmentioning

confidence: 99%

Nation-Wide Survey Assessing the Knowledge and Attitudes of Romanian Pharmacists Concerning Pharmacogenetics

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The most consistent hurdles to PGx testing identified by numerous studies 29,35–38,72,73 are knowledge and education gaps among physicians, pharmacists, genetic counsellors, nurse practitioners, and the public. Studies to date suggest that 80%–90% of health‐care professionals agree about the value of PGx testing in drug selection and dose optimization; however, only 10%–20% are properly trained or confident enough to routinely use PGx testing in their practice 23,73–75 . The lack of training stems from the fact that most medical schools have not integrated pharmacogenomics into their curriculum 76 .…”

Section: Hurdlesmentioning

confidence: 99%

“…Studies to date suggest that 80%-90% of health-care professionals agree about the value of PGx testing in drug selection and dose optimization; however, only 10%-20% are properly trained or confident enough to routinely use PGx testing in their practice. 23,[73][74][75] The lack of training stems from the fact that most medical schools have not integrated pharmacogenomics into their curriculum. 76 In 2016, the Center for the Advancement of Pharmacy Education recommended "pharmacogenomics" to be incorporated into the clinical realm of pharmacy education.…”

Section: Knowledge and Education Gapsmentioning

confidence: 99%

“…18 Notably, the National Health Service Improvement and Genomics England recently announced plans to implement pharmacogenetic testing by 2025. 19 Moreover, members of the International Society of Psychiatric Genetics have published a consensus supporting PGx testing for specific antidepressants, antipsychotics, mood stabilizers and ADHD medications, 20 reflecting the increasingly favorable attitudes toward PGx testing among health-care providers, 21,22 patients, 23 and the public. 24 Despite the growing evidence-base, enthusiasm, and successful efforts to implement PGx testing, a consensus on how best to implement PGx testing into practice has not been established and numerous hurdles to widespread adoption remain to be overcome.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, the National Health Service Improvement and Genomics England recently announced plans to implement pharmacogenetic testing by 2025 19 . Moreover, members of the International Society of Psychiatric Genetics have published a consensus supporting PGx testing for specific antidepressants, antipsychotics, mood stabilizers and ADHD medications, 20 reflecting the increasingly favorable attitudes toward PGx testing among health‐care providers, 21,22 patients, 23 and the public 24 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Approaches and hurdles of implementing pharmacogenetic testing in the psychiatric clinic

Maruf

Bousman

2022

PCN Reports

View full text Add to dashboard Cite

Pharmacogenetic (PGx) testing has emerged as a tool for predicting a person's ability to process and react to drugs. Despite the growing evidence‐base, enthusiasm, and successful efforts to implement PGx testing in psychiatry, a consensus on how best to implement PGx testing into practice has not been established and numerous hurdles to widespread adoption remain to be overcome. In this article, we summarize the most used approaches and commonly encountered hurdles when implementing PGx testing into routine psychiatric care. We also highlight effective strategies that have been used to overcome hurdles. These strategies include the development of user‐friendly clinical workflows for test ordering, use, and communication of results, establishment of test standardization and reimbursement policies, and development of tailored curriculums for educating health‐care providers and the public. Although knowledge and awareness of these approaches and strategies to overcome hurdles alone may not be sufficient for successful implementation, they are necessary to ensure the effective spread, scale, and sustainability of PGx testing in psychiatry and other areas of medicine.

show abstract

Knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students: A systematic review

Wondrasek,

Fryza,

Aziz

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

Background and AimsPharmacists have been recognized as one of the most qualified healthcare professionals in the clinical implementation of pharmacogenomics, yet its widespread implementation in clinical pharmacy practice has remained limited. The review aims to systematically investigate knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students to inform the future delivery of pharmacogenomics education programs.MethodsPubMed, MEDLINE, Embase, Scopus, and the International Pharmaceutical Abstracts were searched up to May 17, 2022. Studies were selected if they included data on pharmacists' or pharmacy students' knowledge, perception, or attitude about pharmacogenomics and were published in a peer‐reviewed, English‐language journal with full‐text availability. Any published study not deemed original research was excluded. All included studies were critically appraised using the Center for Evidence‐Based Management's critical appraisal tools. The data were descriptively analyzed and presented based on pharmacists' and pharmacy students' knowledge/awareness, perception/attitudes toward pharmacogenomic (PGx), confidence in using or interpreting PGx testing results, and their desire to get further PGx education or their most preferred method of further education.ResultsA combined total of 12,430 pharmacists and pharmacy students from 26 countries are represented in the 52 included studies. Despite overwhelmingly positive attitudes and perceptions toward pharmacogenomics among pharmacists and pharmacy students, an overall lack of adequate knowledge and confidence was found. The review also found a strong desire for further pharmacogenomics education among pharmacists and pharmacy students.ConclusionPharmacists and pharmacy students have positive perceptions and attitudes toward pharmacogenomics, which is hindered by a lack of knowledge and confidence. However, inadequate control for confounders, limited representativeness of the studied population or region, and small sample sizes diminish the generalizability of the review results. Knowledge and confidence could be improved through enhanced delivery of pharmacogenomic courses within the pharmacy curriculum and continuing education programs.

show abstract

A systematic review of pharmacogenetic testing in primary care: Attitudes of patients, general practitioners, and pharmacists

Cited by 14 publications

References 32 publications

Nation-Wide Survey Assessing the Knowledge and Attitudes of Romanian Pharmacists Concerning Pharmacogenetics

Nation-Wide Survey Assessing the Knowledge and Attitudes of Romanian Pharmacists Concerning Pharmacogenetics

Approaches and hurdles of implementing pharmacogenetic testing in the psychiatric clinic

Knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students: A systematic review

Contact Info

Product

Resources

About