A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

Li, Mi; Li, Yuchen; Sun, Mengru; Zhang, Peilin; Li, Yang; Yang, Hua

doi:10.1016/s1875-5364(21)60050-x

Cited by 24 publications

(23 citation statements)

References 155 publications

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“…Many new processing methods for Aconitum have been developed in recent years [ 119 , 120 ]. Decoctions are often combined with dried ginger, licorice, and ginseng [ 118 , 121 ]. Examples of these decoction combinations are Sini and Shenfu.…”

Section: Resultsmentioning

confidence: 99%

Higenamine in Plants as a Source of Unintentional Doping

Kozhuharov

Ivanov

Ivanova

2022

Plants

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Background: Higenamine is a β2 agonist of plant origin. The compound has been included in WADA’s prohibited list since 2017. Higenamine may be detected in different plants and many food supplements of natural origin. Methods: Our literature search was conducted through PubMed, Science Direct, Google Scholar, and Web of Science studies investigating the presence of higenamine in plants that are used in traditional folk medicine or included in food supplements. Our study aimed to assess the risk of adverse analytical findings caused by higenamine-containing plants. Results: Based on our literature search, Nelumbo nucifera, Tinospora crispa, Nandina domestica, Gnetum parvifolium, Asarum siebodii, Asarum heterotropoides, Aconitum carmichaelii, and Aristolochia brasiliensis are higenamine-containing plants. Based on data from Eastern folk medicine, these plants can provide numerous health benefits. Professional athletes likely ingest these plants without knowing that they contain higenamine; these herbs are used in treatments for different conditions and various foods/food supplements in addition to folk medicine. Conclusion: Athletes and their teams must be aware of the issues associated with the use of plant-based products. They should avoid consuming higenamine-containing plants during and outside of competition periods.

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Section: Resultsmentioning

confidence: 99%

Higenamine in Plants as a Source of Unintentional Doping

Kozhuharov

Ivanov

Ivanova

2022

Plants

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“…Aconitum alkaloids, which include C19-diterpenoid alkaloids (mainly comprising aconitine, mesaconitine, and hypaconitine) and C20-diterpenoid alkaloids (predominantly benzoylmesaconitine, benzoylaconitine, and benzoylhypacoitine) and other alkaloids (mainly comprising higenamine and salsolinol) have versatile chemical structures ( Zhou et al, 2015 ). Their cardiotoxicity and neurotoxicity hinder the use of Aconitum alkaloids; however, in TCM’s theory that even toxic substances are powerful medicines and can show reduced toxicity by proper methods ( Liu et al, 2017 ; Zong et al, 2019 ; Mi et al, 2021 ). Emerging evidence also shows that Aconitum alkaloids could improve energy metabolism and mitochondrial function to generate cardioprotective effects.…”

Section: Mechanisms Of Traditional Chinese Medicine In Treating Heart...mentioning

confidence: 99%

Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

et al. 2022

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Heart failure (HF) is one of the main public health problems at present. Although some breakthroughs have been made in the treatment of HF, the mortality rate remains very high. However, we should also pay attention to improving the quality of life of patients with HF. Traditional Chinese medicine (TCM) has a long history of being used to treat HF. To demonstrate the clinical effects and mechanisms of TCM, we searched published clinical trial studies and basic studies. The search results showed that adjuvant therapy with TCM might benefit patients with HF, and its mechanism may be related to microvascular circulation, myocardial energy metabolism, oxidative stress, and inflammation.

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“…Diterpenoid alkaloids (DAs) are a large group of highly specialized metabolites that have demonstrated various excellent bioactivities, especially impressive anti‐inflammatory, analgesic and antiarrhythmic effects, which exert great value for related in‐depth investigations. [ 14 ] The tribe Delphineae (Ranunculaceae), which consists of approximately 800 species from two closely related genera, namely, Aconitum L. and Delphinium L., is the richest source of DAs, as more than ninety percent of all naturally occurring DAs have been found within this phytogroup. [ 15‐18 ] However, in Delphineae plants, DAs possessing homologous core skeletons usually coexist in certain species as dozens of structurally similar compounds, which creates a major dereplication obstacle for related phytochemical studies.…”

Section: Background and Originality Contentmentioning

confidence: 99%

2D NMR‐based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids^†

Yin

Liu

et al. 2022

Chin. J. Chem.

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The tribe Delphineae, comprising two genera, Aconitum L. and Delphinium L., is the richest source of bioactive diterpenoid alkaloids (DAs), while their highly similar chemical structures create a major challenge for dereplication from complex mixture. To solve the inefficient discovery process of natural DAs, a novel dereplication strategy based on pattern recognition of specific heteronuclear multiple bond correlation (HMBC) signals has been established in this study. This strategy utilized the diagnostic signals in the HMBC spectra of C 19 -DAs, which could indicate the structural categories. The newly designed software MatchNat allowed in silico recognition of C 19 -DA types. The developed dereplication system was demonstrated to be a practical strategy to dereplicate a variety of natural products from two Delphineae plants, including Aconitum vilmorinianum Kom. and Delphinium pachycentrum Hemsl. Known compounds could be rapidly recognized from the mixture, and novel DAs were found with the aid of MatchNat. Consequently, targeted isolation led to the explosive discovery of a series of novel DAs. This dereplication system has the potential to be adopted for dereplication of any other class of natural products and has shown promising application as a complementary tool in the nuclear magnetic resonance analysis of traditional Chinese medicines.

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A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

Cited by 24 publications

References 155 publications

Higenamine in Plants as a Source of Unintentional Doping

Higenamine in Plants as a Source of Unintentional Doping

Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

2D NMR‐based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids^†

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A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

Cited by 24 publications

References 155 publications

Higenamine in Plants as a Source of Unintentional Doping

Higenamine in Plants as a Source of Unintentional Doping

Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

2D NMR‐based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids†

Contact Info

Product

Resources

About

2D NMR‐based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids^†