A systematic review of prevalence, disease characteristics and management of systemic lupus erythematosus in <scp>A</scp>ustralia: identifying areas of unmet need

Nikpour, Mandana; Bridge, Jeffrey A.; Richter, S.

doi:10.1111/imj.12568

Cited by 39 publications

(31 citation statements)

References 41 publications

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“…The prevalence of SLE in Aboriginal people living in the Darwin, Katherine and East Arnhem regions of the Northern Territory was estimated 20 years ago to be twice that of the non‐Aboriginal Australian population . Several other studies focusing on remote Australian populations have also identified a higher prevalence of SLE in Aboriginal compared with non‐Aboriginal people living in the same regions . One of the authors (PB) collected a database of SLE patients from 2009 to 2015, and estimated prevalence of SLE amongst Top End Aboriginal Australians to be 140 per 100 000 people.…”

Section: Discussionmentioning

confidence: 99%

“…14 Several other studies focusing on remote Australian populations have also identified a higher prevalence of SLE in Aboriginal compared with non-Aboriginal people living in the same regions. 15 One of the authors (PB) collected a database of SLE patients from 2009 to 2015, and estimated prevalence of SLE amongst Top End Aboriginal Australians to be 140 per 100 000 people.…”

Section: Discussionmentioning

confidence: 99%

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Off‐label use of rituximab in autoimmune disease in the Top End of the Northern Territory, 2008–2016

Wongseelashote

Tayal

Bourke

2018

Internal Medicine Journal

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Off‐label use of rituximab in autoimmune disease in the Top End of the Northern Territory, 2008–2016

Wongseelashote

Tayal

Bourke

2018

Internal Medicine Journal

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“…In addition, it has been reported that patients with SLE feel misunderstood by their families, the community and even the specialists treating them [15]. Consequently, patients feel that their quality of life needs are not being met by treating teams [16, 17]. …”

Section: Introductionmentioning

confidence: 99%

Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study

et al. 2017

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BackgroundSystemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous to low disease activity in rheumatoid arthritis, was preliminarily validated as associated with protection from damage accrual. The LLDAS definition has not been previously evaluated for association with patient-reported outcomes. The objective of this study was to determine whether LLDAS is associated with better HR-QoL, and examine predictors of HR-QoL, in a large multiethnic, multinational cohort of patients with SLE.MethodsHR-QoL was measured using the Medical Outcomes Study 36-item short form health survey (SF-36v2) in a prospective study of 1422 patients. Disease status was measured using the SLE disease activity index (SLEDAI-2 K), physician global assessment (PGA) and LLDAS.ResultsSignificant differences in SF-36 domain scores were found between patients stratified by ethnic group, education level and damage score, and with the presence of active musculoskeletal or cutaneous manifestations. In multiple linear regression analysis, Asian ethnicity (p < 0.001), a higher level of education (p < 0.001), younger age (p < 0.001) and shorter disease duration (p < 0.01) remained significantly associated with better physical component scores (PCS). Musculoskeletal disease activity (p < 0.001) was negatively associated with PCS, and cutaneous activity (p = 0.04) was negatively associated with mental component scores (MCS). Patients in LLDAS had better PCS (p < 0.001) and MCS (p < 0.001) scores and significantly better scores in multiple individual SF-36 domain scores. Disease damage was associated with worse PCS (p < 0.001), but not MCS scores.ConclusionsEthnicity, education, disease damage and specific organ involvement impacts HR-QoL in SLE. Attainment of LLDAS is associated with better HR-QoL.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-017-1256-6) contains supplementary material, which is available to authorized users.

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“…4,5 Earlier studies described a high frequency of clinical manifestations of LN in IA patients, 2,3 but there are no data on the underlying renal histopathology in IA. 6 This study investigated the incidence, histological characteristics and clinical outcome of LN in the largest hospital of the Northern Territory (NT), Australia, where approximately 27% of the population identifies as IA. 7 …”

Section: Introductionmentioning

confidence: 99%

Renal histology in Indigenous Australians with lupus nephritis

2017

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A systematic review of prevalence, disease characteristics and management of systemic lupus erythematosus in Australia: identifying areas of unmet need

Abstract: Background: Few epidemiological studies of systemic lupus erythematosus (SLE) have

Cited by 39 publications

References 41 publications

Off‐label use of rituximab in autoimmune disease in the Top End of the Northern Territory, 2008–2016

Off‐label use of rituximab in autoimmune disease in the Top End of the Northern Territory, 2008–2016

Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study

Renal histology in Indigenous Australians with lupus nephritis

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