A systematic review of prevalence and incidence studies of dementia with Lewy bodies

Zaccai, Julia; McCracken, Cherie; Brayne, Carol

doi:10.1093/ageing/afi190

Cited by 295 publications

(203 citation statements)

References 28 publications

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“…Dementia with Lewy bodies (DLB) represents the second most common neurodegenerative form of dementia in the elderly, and is prevalent in up to 30% of all dementia cases in the community (Zaccai et al, 2005). The aggregation of aberrant -synuclein in Lewy bodies and in Lewy neurites is the pathological hallmark of DLB, but it often coexists with the presence of Alzheimer's disease pathology at autopsy in the form of both tau neurofibrillary tangles and amyloid-b neuritic plaques (McKeith et al, 2005;Schneider et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Sarro¹,

Senjem

Lundt

et al. 2016

Brain

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Alzheimer's disease pathology frequently coexists with Lewy body disease at autopsy in patients with probable dementia with Lewy bodies. More than half of patients with probable dementia with Lewy bodies have high amyloid-b deposition as measured with 11 C-Pittsburgh compound B binding on positron emission tomography. Biomarkers of amyloid-b deposition precede neurodegeneration on magnetic resonance imaging during the progression of Alzheimer's disease, but little is known about how amyloid-b deposition relates to longitudinal progression of atrophy in patients with probable dementia with Lewy bodies. We investigated the associations between baseline 11 C-Pittsburgh compound B binding on positron emission tomography and the longitudinal rates of grey matter atrophy in a cohort of clinically diagnosed patients with dementia with Lewy bodies (n = 20), who were consecutively recruited to the Mayo Clinic Alzheimer's Disease Research Centre. All patients underwent 11 C-Pittsburgh compound B positron emission tomography and magnetic resonance imaging examinations at baseline. Follow-up magnetic resonance imaging was performed after a mean (standard deviation) interval of 2.5 (1.1) years. Regional grey matter loss was determined on threedimensional T 1 -weighted magnetic resonance imaging with the tensor-based morphometry-symmetric normalization technique. Linear regression was performed between baseline 11 C-Pittsburgh compound B standard unit value ratio and longitudinal change in regional grey matter volumes from an in-house modified atlas. We identified significant associations between greater baseline 11 C-Pittsburgh compound B standard unit value ratio and greater grey matter loss over time in the posterior cingulate gyrus, lateral and medial temporal lobe, and occipital lobe as well as caudate and putamen nuclei, after adjusting for age (P 5 0.05). Greater baseline 11 C-Pittsburgh compound B standard unit value ratio was also associated with greater ventricular expansion rates (P 5 0.01) and greater worsening over time in Clinical Dementia Rating Scale, sum of boxes (P = 0.02). In conclusion, in patients with probable dementia with Lewy bodies, higher amyloid-b deposition at baseline is predictive of faster neurodegeneration in the cortex and also in the striatum. This distribution is suggestive of possible interactions among amyloid-b, tau and a-synuclein aggregates, which needs further investigation. Furthermore, higher amyloid-b deposition at baseline predicts a faster clinical decline over time in patients with probable dementia with Lewy bodies. Keywords: DLB; structural MRI; beta-amyloid; amyloid imaging; brain atrophy Abbreviations: AChEI = acetylcholinesterase inhibitor; CDR-SOB = Clinical Dementia Rating scale, Sum of Boxes; DLB = dementia with Lewy bodies; MMSE = Mini-Mental State Examination; PiB = 11 C-Pittsburgh compound B; SUVR = standardized uptake value ratio; TBM-SyN = tensor-based morphometry using symmetric diffeomorphic image normalization; UPDRS-III =

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Section: Introductionmentioning

confidence: 99%

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Sarro¹,

Senjem

Lundt

et al. 2016

Brain

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“…Alzheimer's disease (AD) is the most common form of dementia. Dementia with Lewy Bodies (DLB) is likely the second most common form of neurodegenerative dementia with a prevalence between 3% and 26% of all demented cases older than 65 years [9,20]. The clinical picture of DLB constitutes of fluctuations in cognitive performance and consciousness, as well as Parkinsonism, visual hallucinations, falls and severe sensitivity to neuroleptic agents [9].…”

Section: Introductionmentioning

confidence: 99%

Reduced CSF CART in dementia with Lewy bodies

Schultz

Wiehager

Nilsson

et al. 2009

Neuroscience Letters

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Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus.Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n=12) compared to controls (n=12) as well as to AD patients (n=14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

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“…A systematic review of six studies has found prevalence estimates for clinical DLB of up to 30.5% of all dementia cases. (Zaccai et al, 2005) The central feature of DLB is progressive cognitive decline accompanied by fluctuating cognition, visual hallucinations and parkinsonism. Suggestive features are REM sleep behaviour disorder, severe neuroleptic sensitivity and low dopamine transporter uptake in basal ganglia.…”

Section: Introductionmentioning

confidence: 99%

The period of hypotension following orthostatic challenge is prolonged in dementia with Lewy bodies

Andersson

Hansson

Minthon

et al. 2007

Int J Geriat Psychiatry

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ObjectivesTo determine whether orthostatic hypotension (OH) is more common in patients with dementia than in older people without cognitive impairment and to identify key differences in the profile of the orthostatic response and the pulse drive during orthostatic challenge between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).MethodsThe orthostatic response was evaluated in 235 patients with AD, 52 patients with DLB and 62 elderly controls. The blood pressure and pulse rate were measured in supine position, immediately after standing up and after 1, 3, 5 and 10 min of standing. OH was defined as a reduction of systolic blood pressure (SBP) of at least 20 mm Hg or a reduction of diastolic blood pressure (DBP) of at least 10 mm Hg.ResultsOH occurred in 69% of the DLB patients and in 42% of the AD patients, but only in 13% of the controls (p < 0.001 controls vs AD and controls vs DLB, p = 0.001 AD vs DLB) The DLB patients had a greater drop in SBP than the other study groups during orthostatic challenge and had a more prolonged period of orthostasis. The pulse drive on orthostatic challenge was similar in between groups. However, in the DLB group it was not adequate to restore the blood pressure to supine values.ConclusionsPatients with DLB react different to orthostatic challenge than patients with AD or controls, with important clinical implications for key disease symptoms and treatment. Copyright © 2007 John Wiley & Sons, Ltd.

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A systematic review of prevalence and incidence studies of dementia with Lewy bodies

Cited by 295 publications

References 28 publications

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Reduced CSF CART in dementia with Lewy bodies

The period of hypotension following orthostatic challenge is prolonged in dementia with Lewy bodies

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