The aim of this study was to translate into Mexican Spanish, cross-culturally adapt and validate the wound-specific quality of life (QoL) instrument Cardiff wound impact schedule (CWIS) for Mexican patients. This instrument went through the full linguistic translation process based on the guidelines of Beaton et al (Beaton DE, Bombardier C, Guillemin F, Ferraz MB, Guidelines for the process of crosscultural adaptation of self-report measures, Spine Phila Pa, 1976, 2000, 318-391). We included a total of 500 patients with chronic leg ulcers. The expert committee evaluated the Face validity and they agreed unanimously that the instrument was adequate to assess the QoL of these patients, covering all relevant areas presented by them. The content validity index obtained was of 0.95. The construct validity demonstrated moderately significant correlations between related sub-scales of CWIS and SF-36 (P = .010 to P < .001). The instrument was able to discriminate between healed and unhealed ulcers. The instrument obtained an overall Cronbach's alpha of .952, corresponding to an excellent internal consistency (.903-.771 alpha range for domains). The CWIS can be appropriately used to assess the health-related QoL of Mexican patients with chronic leg ulcers. K E Y W O R D S assessment tool, chronic lower limb ulcers, health-related quality of life, wound care 1 | INTRODUCTION Chronic wounds like venous ulcers, diabetic foot ulcers, burns, pressure ulcers and arterial ulcers, among other types, are the result of various diseases. Wound healing involves a number of complex processes that can occur over a long period of time, and the treatment may be quite difficult. These chronic wounds provoke additional complications such as lack of mobility, pain, exudate and odour. 1-5 Emotional stress due to fear of recurrence of ulceration, impaired body image, social isolation, increased family tensions, restrictions in employment and repeated bouts of infection and potential lifelong morbidity exaggerates the negative influences of the wounds on these patients. 6,7 These factors report increased depression and less satisfaction with life, and have poorer psychosocial adjustment to illness. 8-10 Due to all of these issues, chronic ulcers affect physical, psychological, social and financial aspects of the individual, leading to poor quality of life (QoL). 2,11-13 QoL is defined by the World Health Organization (WHO) as an individual's perception of their position in life in the context of the culture and value systems in which they