A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars

Truong, Kelvin; Prasidha, Ines; Wain, Tevi

doi:10.1007/s10103-021-03296-z

Cited by 11 publications

(6 citation statements)

References 31 publications

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“…Using laser that penetrates only the cuticle and superficial epidermis can increase the transdermal absorption of drugs and avoid other side effects. 37 Because the penetration depth is shallow and the repair speed is fast, skin trauma will not be caused. There are no visible erythema, edema and other inflammatory reactions at the treatment site, and no other side effects will be caused.…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective study was conducted to evaluate the efficacy of a wavelength of 2 940 nm dot array laser combined with betamethasone ointment in the treatment of keloid. 36 , 37 Results showed that the average response rate was 50%, especially for hypertrophic scar formation after acne (response rate was 77%), and the average patient satisfaction rate was 70%.…”

Section: Application Of Laser-assisted Transdermal Drug Deliverymentioning

confidence: 99%

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Principles and clinical applications of transcutaneous laser-assisted drug delivery: A narrative review

Liu,

Sood,

Wang

et al. 2024

Scars, Burns & Healing

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Introduction Transcutaneous laser-assisted drug delivery (LADD) is recognized as a developing therapy for skin disorders. Method Current literature was reviewed to summarize current applications for LADD. Discussion 12 clinical applications for this therapy are currently reported. Conclusion LADD has potential for wide application in skin disorder treatment. Lay Summary Laser assisted drug delivery improves drug bioavailability for treatment of skin disorders. This technique is being assessed clinically in disorders ranging from skin cancers to alopecia.

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Section: Discussionmentioning

confidence: 99%

Section: Application Of Laser-assisted Transdermal Drug Deliverymentioning

confidence: 99%

Principles and clinical applications of transcutaneous laser-assisted drug delivery: A narrative review

Liu,

Sood,

Wang

et al. 2024

Scars, Burns & Healing

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“…Although there are specific types of lasers depending on depth and pigment target including pulse-dye laser (PDL) (for erythema), carbon dioxide, (CO 2 ) (for ablation), neodymium-doped yttrium aluminum garnet (Nd: YAG) (for post-inflammatory pigmentation). More recently, laser-assisted drug delivery (LAAD), is popularized where a topical agent is applied to a targeted area, as a “two-pronged” attack ( 57 ). This approach is thought to increase the bioavailability of the drugs used, and shown to be of benefit in keloids ( 57 ).…”

Section: Current Management Strategiesmentioning

confidence: 99%

“…More recently, laser-assisted drug delivery (LAAD), is popularized where a topical agent is applied to a targeted area, as a “two-pronged” attack ( 57 ). This approach is thought to increase the bioavailability of the drugs used, and shown to be of benefit in keloids ( 57 ). Photodynamic therapy (PDT) is widely used to treat skin cancers due to its cytotoxic effect, induction of fibrotic tissue degradation, by decreasing collagen I and III gene expression is now also used for treatment of raised scar endotypes, although current evidence on therapeutic efficacy is limited ( 58 ).…”

Section: Current Management Strategiesmentioning

confidence: 99%

Skin scarring: Latest update on objective assessment and optimal management

Basson

2022

Front. Med.

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Although skin scarring is considered by some to be a minor, unavoidable consequence in response to skin injury, for many patients, cosmetically unsightly scars may cause uncomfortable symptoms and loss of function plus significant psycho-social distress. Despite their high prevalence and commonality, defining skin scars and their optimal management has proven problematic. Therefore, a literature search to assess the current evidence-base for scarring treatment options was conducted, and only those deemed Levels of Evidence 1 or 2 were included. Understanding the spectrum of skin scarring in the first instance is imperative, and is mainly comprised of four distinct endotypes; Stretched (flat), Contracted, Atrophic, and Raised for which the acronym S.C.A.R. may be used. Traditionally, scar assessment and response to therapy has employed the use of subjective scar scales, although these are now being superseded by non-invasive, objective and quantitative measurement devices. Treatment options will vary depending on the specific scar endotype, but fall under one of 3 main categories: (1) Leave alone, (2) Non-invasive, (3) Invasive management. Non-invasive (mostly topical) management of skin scarring remains the most accessible, as many formulations are over-the-counter, and include silicone-based, onion extract-based, and green tea-based, however out of the 52 studies identified, only 28 had statistically significant positive outcomes. Invasive treatment options includes intralesional injections with steroids, 5-FU, PDT, and laser with surgical scar excision as a last resort especially in keloid scar management unless combined with an appropriate adjuvant therapy. In summary, scar management is a rapidly changing field with an unmet need to date for a structured and validated approach.

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“…Additionally, the pressure generated by the bubbles can increase the propulsion efficiency of the laser in water [16] . Thus, some researchers are using underwater laser propulsion in a variety of applications, such as underwater impact molding [17] , underwater laser cleaning [18][19] and drug transportation [20] . With further research development, the goal of laser propulsion has changed from macro to micro.…”

Section: Introductionmentioning

confidence: 99%

Study on nanosecond pulse laser propulsion microspheres based on a tapered optical fiber in water environment

Zhou,

Li,

Yang

et al. 2023

AOPC 2023: Laser Technology and Applications; And Optoelectronic Devices and Integration

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A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars

Cited by 11 publications

References 31 publications

Principles and clinical applications of transcutaneous laser-assisted drug delivery: A narrative review

Principles and clinical applications of transcutaneous laser-assisted drug delivery: A narrative review

Skin scarring: Latest update on objective assessment and optimal management

Study on nanosecond pulse laser propulsion microspheres based on a tapered optical fiber in water environment

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