This chapter delves into the multifaceted relationship that self-rumination has with depression and suicidality through psychological, neurological, and linguistic lenses. It explores how self-focused thoughts and language contribute to depressive symptoms and suicidal behaviors. The psychological section examines the self-focus model, differentiates between rumination and reflection, and highlights their impacts on happiness and social functioning. The neurological section investigates brain areas like the default mode network, medial prefrontal cortex, and anterior cingulate cortex, focusing on the roles of these regions in self-referential processing and emotional regulation. The linguistic section discusses how language use, particularly self-focused language, reflects underlying psychological conditions and ruminative patterns. Finally, the chapter synthesizes the observations of the relevant studies, with the aim of providing a comprehensive understanding of how self-rumination exacerbates depression and suicidality.