ConclusionsPharmacological methods seem to focus on managing withdrawal, and hold little promise in managing or preventing relapses, except varenicline. Despite heavy emphasis placed on NRT, nortriptyline seems to be safer, cheaper and equally effective. Brief advice given by doctors is as effective as NRT.Which non-pharmacological method work best with regards to relapse prevention is yet to be determined. Psychiatrists may use MI or personalised psychoeducation with or without nortriptyline, NRT, bupropion or varenicline. Clonidine is reserved as a second line intervention for inpatients. NRT may also be useful for temporary withdrawal of tobacco use for heavy smokers who are unwilling to quit. E-cigarettes are not to be recommended. Further research on unassisted cessation, safer interventions such as simple advice, and the role of tobacco and pharmaceutical industries is needed. New treatment guidance, better informed by evidence, is warranted.