A systematic review of the structural neuroimaging correlates of thought disorder

Sumner, Philip; Bell, Imogen; Rossell, Susan L.

doi:10.1016/j.neubiorev.2017.08.017

Cited by 47 publications

(42 citation statements)

References 189 publications

(342 reference statements)

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“…Furthermore, the present study is in line with the recent mCCA + jICA study by Lottman and colleagues (Lottman et al, ), once again highlighting the relationship between GMV alterations and aberrant INA in SSD. In particular, the aberrant interrelationships between GMV and INA might contribute to the explanation of very heterogeneous symptoms in SSD patients (Kubera et al, ; Sumner, Bell, & Rossell, , ).…”

Section: Discussionmentioning

confidence: 99%

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Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Hirjak

Rashidi

Fritze

et al. 2019

Human Brain Mapping

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Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co‐altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right‐handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion technique for multimodal MRI data—multiset canonical correlation and joint independent component analysis (mCCA + jICA)—to investigate co‐altered patterns of GMV and intrinsic neural fluctuations (INF) in SSD patients exhibiting NSS. The mCCA + jICA model indicated two joint group‐discriminating components (temporoparietal/cortical sensorimotor and frontocerebellar/frontoparietal networks) and one modality‐specific group‐discriminating component (p < .05, FDR corrected). NSS motor score was associated with joint frontocerebellar/frontoparietal networks in SSD patients. This study highlights complex neural pathomechanisms underlying NSS in SSD suggesting aberrant structure and function, predominantly in cortical and cerebellar systems that critically subserve sensorimotor dynamics and psychomotor organization.

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Section: Discussionmentioning

confidence: 99%

“…In particular, the aberrant interrelationships between GMV and INA might contribute to the explanation of very heterogeneous symptoms in SSD patients Sumner, Bell, & Rossell, 2018a, 2018b.…”

Section: Group Differencesmentioning

confidence: 99%

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Hirjak

Rashidi

Fritze

et al. 2019

Human Brain Mapping

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“…The role of cerebellum in non‐motor functions is also explained by cerebrocerebellar channels that connect motor, association and parahippocampal cortex in the supratentorial brain with cerebellum, in particular the cortico‐ponto‐cerebellar and cerebello‐thalamo‐cortical loops. Moreover a bidirectional pathway connecting cerebellum and hypothalamus has been detected specifically involved in hypothalamic function (Benagiano et al ).Imaging studies have shown morphologic patterns in cerebellum in diseases like autism, schizophrenia and mood disorders (Olivito et al ; Ismail et al ; Igelström et al ; Keehn et al ; D'Mello and Stoodley ; Jiang et al ; Sumner et al ; Cierpka et al ).…”

Section: Discussionmentioning

confidence: 99%

Functional MRI activation patterns of cerebellum in patients with epilepsy and brain tumors

Zacharia

Eslinger

2019

Clinical Anatomy

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Function of cerebellum in control and coordination of motor function has been well established for several years. Recent functional magnetic resonance imaging (MRI) studies reveal activation of cerebellum with memory, speech and language tasks. We hypothesize that during every function in the brain signals are relayed to cerebellum. We seek to analyze cognitive, emotional and social functions of cerebellum in patients with brain tumors and epilepsy utilizing functional Magnetic Resonance Imaging. Fifty-one consecutive adult patients who underwent functional MRI examination were retrospectively analyzed for various activation patterns involving cerebellum. The neuropsychological battery of tasks assessed motor, language, memory, visual and auditory functions. Cognitive ability of all participants was assessed by Montreal cognitive assessment (MOCA). Patterns were analyzed for specific lobes and locations in the cerebellum. We found that simultaneous cerebellar activation is a consistent finding with brain activation during every functional MRI task that we tested except visual task. The patterns of functional MRI cerebellar activation were similar in both patient subgroups and control subjects compared to previously described patterns in normal subjects.

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“…The search method was conducted to discover the neuroimaging literature pertaining to TD. In addition to task-based functional neuroimaging studies, the search returned relevant structural (see Sumner et al, 2018), resting-state functional, and neurochemical neuroimaging studies that were not included in the current review.…”

Section: Search Protocolmentioning

confidence: 99%

“…One avenue to help elucidate the contributions of these cognitive processes to the manifestation of TD is through the use of neuroimaging. The most replicated structural correlates of TD (for reviews, see Cavelti et al, 2018;Sumner et al, 2018) encompass reduced volumes within the left posterior superior temporal gyrus, including the planum temporale (Anderson et al, 2002;Barta et al, 1997;Horn et al, 2009;Rajarethinam et al, 2000;Sans-Sansa et al, 2013;Shenton et al, 1992;Weinstein et al, 2007). However, other replicated findings implicate the left and/or right orbitofrontal cortex (Gur et al, 2004;Horn et al, 2010;Nakamura et al, 2008;Sans-Sansa et al, 2013), the left amygdala-hippocampus complex (Bogerts et al, 1993;Rajarethinam et al, 2001;Sallet et al, 2003;Spalletta et al, 2010), the bilateral nucleus accumbens (Ballmaier et al, 2004;Spalletta et al, 2010), the cerebellar vermis (Sandyk et al, 1991), and the corpus callosum (Arnedo et al, 2015;Kubicki et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A systematic review of task-based functional neuroimaging studies investigating language, semantic and executive processes in thought disorder

Sumner

Bell

Rossell

2018

Neuroscience & Biobehavioral Reviews

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A systematic review of the structural neuroimaging correlates of thought disorder

Cited by 47 publications

References 189 publications

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Functional MRI activation patterns of cerebellum in patients with epilepsy and brain tumors

A systematic review of task-based functional neuroimaging studies investigating language, semantic and executive processes in thought disorder

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