A Systematic Review of the Uterine Relaxant Effect of Herbal Sources

Rezaeizadeh, Golnaz; Hantoushzadeh, Sedigheh; Ghiasi, Sima; Nikfar, Shekoufeh; Abdollahi, Mohammad

doi:10.2174/1389201017666160630192037

Cited by 14 publications

(8 citation statements)

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“…New drugs or herbal extracts are being used in in vitro and in vivo PTB models to explore their possible therapeutic benefits. There are some herbal extract compounds, such as the terpene and flavonoid classes, that have showed relaxing properties on uterine smooth muscle (Rezaeizadeh, Hantoushzadeh, Ghiasi, Nikfar, & Abdollahi, 2016). Citral is present in the oils of several plants, including lemon myrtle (Sharma et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

In vitro effects of citral on the human myometrium: Potential adjunct therapy to prevent preterm births

Muñoz-Pérez

Ortiz

Salas-Casa

et al. 2021

Birth Defects Research

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Background: Premature infants contribute to infant morbidity and mortality especially in low resource settings. Information on tocolytic and/or antiinflammatory effects of several plant extracts, such as citral, could help prevent preterm birth cases and reduce the number of preterm infants. The aim of this study was to evaluate the in vitro tocolytic and anti-inflammatory effect of citral on myometrial tissues of the human uterus.Methods: Myometrial samples from uteri obtained after hysterectomy were used in functional tests to evaluate the inhibitory effect of citral on PGF-2α induced contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to citral in human myometrial homogenates were measured by ELISAs. Forskolin was used as a positive control. The anti-inflammatory effect of citral was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-α (TNFα) and interleukin (IL)-1β, and the anti-inflammatory cytokine IL-10, in human myometrial explants stimulated with lipopolysaccharide (LPS).Results: Citral was able to induce a significant inhibition of PGF-2α induced contractions at the highest concentration level (p < .05). Citral caused a concentration-dependent increase in myometrial cAMP levels (p < .05) and a concentration-dependent decrease in LPS-induced TNFα and IL-1β production, while IL-10 production increased significantly (p < .05). The antiinflammatory and tocolytic effects induced by citral could be associated with an increase in cAMP levels in human myometrial samples. Conclusion:These properties place citral as a potentially safe and effective adjuvant agent in preterm birth cases, an obstetric and gynecological problem that requires urgent attention.

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Section: Discussionmentioning

confidence: 99%

In vitro effects of citral on the human myometrium: Potential adjunct therapy to prevent preterm births

Muñoz-Pérez

Ortiz

Salas-Casa

et al. 2021

Birth Defects Research

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“…Therefore, new drugs or herbal extracts are being used in preterm birth models both in vitro and in vivo in order to explore their possible therapeutic benefits. Recently, some herbal extract compounds, such as the terpene and flavonoid classes, have been linked to properties with a relaxing effect on uterine smooth muscle [ 17 ]. α-Bisabolol is a natural unsaturated monocyclic sesquiterpene alcohol obtained mainly from Matricaria recutita and Myoporum crassifolium [ 8 9 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus

Muñoz-Pérez

Ortiz

Ponce‐Monter

et al. 2018

Korean J Physiol Pharmacol

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The aim of this study was to evaluate the in vitro anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human myometrium. Samples from the pregnant human myometrium were used in functional tests to evaluate the inhibitory effect of α-bisabolol (560, 860, 1,200 and 1,860 µM) on spontaneous myometrial contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to α-bisabolol in human myometrial homogenates were measured by ELISA. The anti-inflammatory effect of α-bisabolol was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-α (TNFα) and interleukin (IL)-1β, and the anti-inflammatory cytokine IL-10, in pregnant human myometrial explants stimulated with lipopolysaccharide (LPS). Forskolin was used as a positive control to evaluate the cAMP and cytokine levels. α-Bisabolol was found to induce a significant inhibition of spontaneous myometrial contractions at the highest concentration level (p<0.05). α-Bisabolol caused a concentration-dependent decrease in myometrial cAMP levels (p<0.05) and a concentration-dependent decrease in LPS-induced TNFα and IL-1β production, while IL-10 production did not increase significantly (p>0.05). The anti-inflammatory and utero-relaxant effects induced by α-bisabolol were not associated with an increase in cAMP levels in pregnant human myometrial samples. These properties place α-bisabolol as a potentially safe and effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.

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“…Phytochemical screening of the leaves for both plants revealed the presence of terpenoids in FDA aqueous extract (Umi Romaizatul Amiera et al 2014). this compound also has been implicated as chemical stimuli that can trigger smooth muscle contraction (Rezaeizadeh et al 2016;Sommer et al 2017). however, the exact role of terpenoids and its association with increased expression level of phosphorylated p42/44 MAPK protein is not known.…”

Section: Discussionmentioning

confidence: 99%

Mechanism Identification of Ficus Deltoidea Aqueous Extract in Rat Uterine Contractions

Ibrahim

Derased

Zainudin

et al. 2018

JSKM

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Ficus deltoidea or 'mas cotek,' is a uterotonic herb traditionally consumed by women to improve menstrual circulation, assist labour, remove retained placenta and treat postpartum bleeding. The aim of the study was to elucidate the mechanism of F. deltoidea in uterine contraction. Crude extracts from 2 different variants of F. deltoidea were used in the study; F. deltoidea var. Deltoidea (FDD) and F. deltoidea var. Angustifolia (FDA). This study was conducted ex vivo on the strips of isolated rats uterus treated with either FDD or FDA aqueous extract with increasing concentrations ranging from 10 µg/ ml until 1280 µg/ml at time intervals of 5 minutes between doses. The frequency and intensity of the uterine contractions were monitored via Powerlab software. Maximum contractions for both extracts were identified, recorded and the uterine strips samples at maximum contraction were selected and homogenized in order determine the role of prostaglandin F2α (PGF2α) in the mechanism of uterine contraction. Other than that, phosphorylated 42/44 (p42/44) of mitogen activated protein kinase (MAPK) expression was also detected via immunoblotting. The results showed that the maximum contraction induced by FDD was at the concentration of 320 µg/ml, whereas for FDA was at 960 µg/ml. Both FDD and FDA increased the intensity of uterine strips contractions and there were notable trend of increased PGF2α expression as well. Further analysis revealed that the uterine contractions involved the MAPK pathway through the phosphorylation of p42/44 protein. In conclusion, Ficus deltoidea of both variants have the ability to stimulate uterine contraction through the mechanism of MAPK pathway.

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A Systematic Review of the Uterine Relaxant Effect of Herbal Sources

Cited by 14 publications

References 0 publications

In vitro effects of citral on the human myometrium: Potential adjunct therapy to prevent preterm births

In vitro effects of citral on the human myometrium: Potential adjunct therapy to prevent preterm births

Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus

Mechanism Identification of Ficus Deltoidea Aqueous Extract in Rat Uterine Contractions

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