A Systematic Review of the safety of non-TNF inhibitor biologic and targeted synthetic drugs in rheumatic disease in pregnancy

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids

“…Data relating to non-TNFi biologic use in pregnancy remain scarce, and in this guideline updated case reports and small case series were excluded for consistency. A recent systematic review summarized all available data (including case reports) on non-TNFi bDMARDs and tsDMARDs and did not identify any adverse safety signals [ 342 ].…”

“…Data relating to tsDMARD use in pregnancy remain scarce, and in this guideline, updated case reports and small case series were excluded for consistency. A recent systematic review summarized all available data including case reports and raised no additional safety concerns [ 342 ]. No studies were found relating to apremilast use in pregnancy, and therefore we were unable to make any recommendations.…”