Background: Literature suggests that eHealth interventions can improve the efficiency and accuracy of health service delivery, improve health outcomes, and are generally well received by patients; however, there is limited data on provider experiences using eHealth interventions in resource-limited settings. The HITSystem is an eHealth intervention designed to improve early infant diagnosis (EID) outcomes among HIV-exposed infants.Objective: We aimed to compare providers' experiences with standard EID and HITSystem implementation at 6 Kenyan hospitals and 3 laboratories with the goal of highlighting the multilevel factors that may facilitate or impede the uptake of eHealth in similar settings.
Methods:As part of a randomized control trial to evaluate the HITSystem, we conducted semi-structured interviews with 17 EID providers at participating intervention and control hospitals and laboratories. We used the Consolidated Framework for Implementation Research (CFIR) to guide data coding and analysis.Results: Qualitative analysis revealed salient themes falling under 11 constructs within 3 domains of the CFIR model (inner setting, outer setting, and intervention characteristics). Providers emphasized relative advantages of the HITSystem over standard EID as strong facilitators to implementation, including improved efficiency in sample tracking and patient follow up, strengthened communication networks among key stakeholders, and improved capacity to meet patient needs. These advantages were realized from an intervention that providers saw as easy to use and compatible with workflow. Supply stock outs and patient psychosocial factors (including disclosure, stigma, and poverty) provided on-going challenges to EID service provision. Furthermore, slow or sporadic access to Internet and heavy workload prevented real-time HITSystem data entry for some clinicians.Discussion: Providers underscored the relative advantages of the HITSystem over standard EID as the primary facilitator of implementation. These results suggest that eHealth interventions can maximize implementation success by ensuring that end-users can see clear advantages of intervention use and can easily integrate it into varying workflows.Trial Registration: clinicaltrials.gov, NCT02072603: https://clinicaltrials.gov/ct2/show/NCT02072603