A systematic review of the biological mechanisms linking physical activity and breast cancer

Hong, Bok Sil; Lee, Kang Pa

doi:10.20463/pan.2020.0018

Cited by 34 publications

(35 citation statements)

References 70 publications

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“…In addition, sarcopenic obesity leads to an increased risk of developing various diseases, such as hypertension, diabetes, hyperlipidemia, and arteriosclerosis ( Atkins and Wannamathee, 2020 ). Cardiometabolic-related indicators are highly correlated with the risk of major cancers, such as colon cancer, pancreatic cancer, and breast cancer, which are major causes of death in adults ( Stefan et al, 2016 ; Ma et al, 2017 ; Huh et al, 2018 ; Hong and Lee, 2020 ). In particular, the elderly have a correlation with metabolic syndrome (MetS), accompanied by coronary artery diseases, myocardial infarction, and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Sarcopenia, Obesity, Osteoporosis, and Cardiometabolic Health Conditions and Physical Activity Levels in Korean Older Adults

et al. 2021

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This study aimed to analyze the status of sarcopenia, obesity, osteoporosis, and cardiometabolic disease according to the level of physical activity (PA) among elderly people in Korea. Among the data obtained from the National Health and Nutrition Survey (2008–2011), we analyzed the data of a total of 3,573 Korean elderly people over 65 years of age who were surveyed for dual X-ray absorptiometry (DXA) and PA. Higher levels of PA were associated with a lower prevalence of cardiometabolic disease (χ2 = 33.865, p < 0.001), osteoporosis (χ2 = 94.198, p < 0.001), sarcopenia, obesity, and sarcopenic obesity (χ2 = 71.828, p < 0.001). Above moderate-active PA was associated with lower body weight (p < 0.001), body fat mass (p < 0.001), and percent body fat (p < 0.001), and higher free-fat mass (p < 0.001) and appendicular skeletal muscle mass (ASM) (p < 0.001) than in low-active PA. In addition, when high-active is the risk factors of cardiometabolic were lower in waist circumference (p = 0.001), total cholesterol (TC) (p = 0.015), and triglyceride (TG) (p < 0.001) than low- and moderate-active PA, and higher in high-density lipoprotein cholesterol (HDL-C) (p < 0.001). The prevalence of cardiometabolic diseases was significantly decreased in high-active PA (odds ratio (OR) 0.60, 95% confidence interval (CI) 0.50–0.71); waist circumference (OR 0.85, 95% CI, 0.73–0.99; OR 0.59, 95% CI, 0.50–0.70) and HDL-C (OR 0.76, 95% CI, 0.65–0.88; OR 0.56, 95% CI, 0.47–0.67) significantly improved in moderate- and high-active PA, respectively, and TG (0.67 95% CI, 0.55–0.80) significantly improved in high-active PA. Osteoporosis (OR 0.62, 95% CI, 0.53–0.74; OR 0.46, 95% CI, 0.38–0.55) and sarcopenia (OR 0.77, 95% CI, 0.60–0.98; OR 0.73, 95% CI, 0.57–0.93) were significantly improved in moderate- and high-active PA, respectively. The incidence of obesity (OR 0.47, 95% CI, 0.39–0.57) and sarcopenic obesity (OR 0.47, 95% CI, 0.30–0.75) were significantly decreased in high-active PA. Therefore, we verified a lower prevalence of sarcopenia, osteoporosis, obesity, and cardiac metabolic disease in Korean elderly with more active PA. This suggests that more active PA maybe reduce the prevalence of sarcopenia, osteoporosis, obesity, and cardiometabolic diseases in older adults.

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Section: Introductionmentioning

confidence: 99%

Relationship Between Sarcopenia, Obesity, Osteoporosis, and Cardiometabolic Health Conditions and Physical Activity Levels in Korean Older Adults

et al. 2021

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“…Physical inactivity is a major risk factor for the development of breast cancer and its prevalence is higher in women than men [ 29 , 30 , 31 ]. Decreased levels of physical preparedness, treatment side effects, and stress from being diagnosed with cancer all play a role in exacerbating the clinical conditions of a breast cancer person [ 31 , 32 ]. Studies have shown that exercise as a non-invasive and non-pharmacological treatment directly affects the components of breast cancer and improves the QoL of patients [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise on depression and fatigue in breast cancer women undergoing chemotherapy: A randomized controlled trial

Mostafaei

Azizi

Jalali

et al. 2021

Heliyon

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Background Depression and fatigue are common consequences of breast cancer that lead to dysfunction and reduced quality of life of patients. The aim of the present study was to determine the effect of exercise program on depression and fatigue in breast cancer women undergoing chemotherapy. Methods This randomized controlled trial study was performed on 60 breast cancer women undergoing chemotherapy in Kermanshah hospitals from 2017-2018. Participants were selected using convenience sampling and were randomly divided into intervention and control groups. Data collection tools included demographic information form and standard Beck depression inventory (BDI-II) and fatigue severity scale (FSS). The intervention group performed the 20-30-minute indoor exercise program 3 sessions a week for 6 weeks. Questionnaires were completed before, immediately, and one month after the intervention by both groups and data analysis was carried out using SPSS ver.22. Results There was no statistically significant difference between the two groups in terms of the mean fatigue intensity and depression scores before the intervention; however, the mean fatigue intensity scores were significantly decreased in the intervention group as compared to the control group immediately and one month after the intervention (P = 0.001). There was no statistically significant difference between the two groups in terms of mean depression score immediately and one month after the intervention (p > 0.05). Conclusion Considering that indoor exercises reduced fatigue in breast cancer women undergoing chemotherapy, patients are recommended to perform exercise interventions as a non-pharmacological, safe, easy, and non-invasive solution to improve their physiological capacities and functional abilities as well as Quality of life. On the other hand, since exercise program had no effect on depression among breast cancer women in the present study, longer studies with larger sample size are recommended.

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“…Moreover, an association between the level of physical activity and progression-free survival of patients with metastatic colorectal cancer has recently been described [77]. The protective effects are governed by multiple local and systemic mechanisms, mediated by hormones, metabolites, inflammatory factors, myokines and miRNAs [78]. In the past five years, evidence has accumulated that physical activity and exercise induce the release of EVs that contain functional molecules which are involved in the communication between tissues and organs [79][80][81].…”

Section: Evs In Physical Exercise-tumor Cross-talkmentioning

confidence: 99%

Extracellular Vesicles and Their Role in the Spatial and Temporal Expansion of Tumor–Immune Interactions

Lipinski

Tiemann

2021

IJMS

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Extracellular vesicles (EVs) serve as trafficking vehicles and intercellular communication tools. Their cargo molecules directly reflect characteristics of their parental cell. This includes information on cell identity and specific cellular conditions, ranging from normal to pathological states. In cancer, the content of EVs derived from tumor cells is altered and can induce oncogenic reprogramming of target cells. As a result, tumor-derived EVs compromise antitumor immunity and promote cancer progression and spreading. However, this pro-oncogenic phenotype is constantly being challenged by EVs derived from the local tumor microenvironment and from remote sources. Here, we summarize the role of EVs in the tumor–immune cross-talk that includes, but is not limited to, immune cells in the tumor microenvironment. We discuss the potential of remotely released EVs from the microbiome and during physical activity to shape the tumor–immune cross-talk, directly or indirectly, and confer antitumor activity. We further discuss the role of proinflammatory EVs in the temporal development of the tumor–immune interactions and their potential use for cancer diagnostics.

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A systematic review of the biological mechanisms linking physical activity and breast cancer

Cited by 34 publications

References 70 publications

Relationship Between Sarcopenia, Obesity, Osteoporosis, and Cardiometabolic Health Conditions and Physical Activity Levels in Korean Older Adults

Relationship Between Sarcopenia, Obesity, Osteoporosis, and Cardiometabolic Health Conditions and Physical Activity Levels in Korean Older Adults

Effect of exercise on depression and fatigue in breast cancer women undergoing chemotherapy: A randomized controlled trial

Extracellular Vesicles and Their Role in the Spatial and Temporal Expansion of Tumor–Immune Interactions

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