A Systematic Review of the Association between Sedentary Behavior and Non-Motor Symptoms of Parkinson’s Disease

Abstract

BackgroundParkinson’s disease, known for motor symptoms, often brings early non-motor issues that severely affect patients’ quality of life. While there are not many effective treatments, physical activity and exercise can help. Yet, another component of the movement intensity continuum warrants examination—prolonged sitting or sedentary behavior. Thus, aim of this study was to perform a systematic review to investigate the relationship between sedentary behaviour and non-motor symptoms, specifically cognitive decline, depression and sleep deficits in Parkinson’s disease.MethodsConforming to PRISMA guidelines, we reviewed the literature up to February 28, 2023, to investigate how sedentary behavior correlates with non-motor symptoms such as cognitive impairment, depression, and sleep disturbances in Parkinson’s disease. A systematic search of the literature was conducted via electronic databases including MEDLINE, CINAHL, Scopus, PubMed and PsycINFO. The eligibility criteria for study selection was: (i) If it studied the Individuals with Parkinson’s disease with sedentary behaviour(iii) studies investigating the association between sedentary behavior and at least one of the non-motor symptoms, including depression, sleep quality, and/or cognitive impairment. New-castle-Ottawa scale for cross-sectional and cohort studies was used to perform quality assessment of the studies.ResultsOf the 463 publications found, 7 studies met the inclusion criteria. All the studies were observational. Total number of cases across all studies were 980. Collectively, these studies show that prolonged sedentary time is associated with increased cognitive, depressive, and sleep-related problems.ConclusionRecognizing sedentary behavior as an independent factor holds pivotal significance. The intricate relationship between sedentary behavior and Parkinson’s disease non-motor symptoms necessitates further exploration to potentially enhance therapeutic strategies for those living with the disease.