A systematic review of the evidence on the effectiveness and risks of inactivated influenza vaccines in different target groups

Michiels, Bart; Govaerts, Frans; Remmen, Roy; Vermeire, Etienne; Coenen, Samuel

doi:10.1016/j.vaccine.2011.08.008

Cited by 133 publications

(102 citation statements)

References 59 publications

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“…12 In randomized clinical trials (RCTs) among healthy adults, vaccine efficacy ranges from 16 to 76%, with a median of 50% (interquartile range: 42-68). 13,14 VE is similar in observational studies. The US Flu Vaccine Effectiveness Network estimates VE every year in the USA, in adults aged 18 to 49 years.…”

Section: Benefits and Risks In Healthcare Settingssupporting

confidence: 78%

Vaccination of healthcare workers: A review

Haviari

Bénet

Saadatian‐Elahi

et al. 2015

Human Vaccines & Immunotherapeutics

155

124

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Section: Benefits and Risks In Healthcare Settingssupporting

confidence: 78%

Vaccination of healthcare workers: A review

Haviari

Bénet

Saadatian‐Elahi

et al. 2015

Human Vaccines & Immunotherapeutics

155

124

View full text Add to dashboard Cite

“…The protection in children (range 20–77%) and in healthy adults (range 50–59%) seen in the tropics and subtropics was comparable with that seen in developed countries 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74. Vaccine protection studies from the tropics and subtropics faced certain limitations.…”

Section: Discussionsupporting

confidence: 57%

Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics – a systematic literature review

Hirve

Lambach

Paget

et al. 2016

Influenza Resp Viruses

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AimThe evidence needed for tropical countries to take informed decisions on influenza vaccination is scarce. This article reviews policy, availability, use and effectiveness of seasonal influenza vaccine in tropical and subtropical countries.MethodGlobal health databases were searched in three thematic areas – policy, availability and protective benefits in the context of human seasonal influenza vaccine in the tropics and subtropics. We excluded studies on monovalent pandemic influenza vaccine, vaccine safety, immunogenicity and uptake, and disease burden.ResultsSeventy‐four countries in the tropics and subtropics representing 60% of the world's population did not have a national vaccination policy against seasonal influenza. Thirty‐eight countries used the Northern Hemisphere and 21 countries the Southern Hemisphere formulation. Forty‐six countries targeted children and 57 targeted the elderly; though, the age cut‐offs varied. Influenza vaccine supply increased twofold in recent years. However, coverage remained lower than five per 1000 population. Vaccine protection against laboratory‐confirmed influenza in the tropics ranged from 0% to 42% in the elderly, 20–77% in children and 50–59% in healthy adults. Vaccinating pregnant women against seasonal influenza prevented laboratory‐confirmed influenza in both mothers (50%) and their infants <6 months (49–63%).ConclusionGuidelines on vaccine composition, priority risk groups and vaccine availability varied widely. The evidence on vaccine protection was scarce. Countries in the tropics and subtropics need to strengthen and expand their evidence‐base required for making informed decisions on influenza vaccine introduction and expansion, and how much benefit to expect.

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“…[11,[92][93][94] Special considerations Vaccination coverage among HCWs remains low, despite the relative accessibility of this target population, as well as a number of efforts to increase coverage (recommendations from major health care organizations, educational campaigns, free and easily available vaccines). [17,[95][96][97][98][99] A systematic review of HCW attitudes toward influenza vaccine identified two critical reasons for lack of vaccine uptake.…”

Section: Vaccine Safetymentioning

confidence: 99%