2018
DOI: 10.1016/j.critrevonc.2018.01.003
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A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors

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Cited by 260 publications
(214 citation statements)
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References 41 publications
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“…Three or four weeks after completion of CCRT, two additional cycles of consolidation chemotherapy (docetaxel 75mg/m 2 on day 1 and cisplatin 25mg/m 2 on days 1-3) were performed at 3-or 4-weeks intervals. (b) Patients were administered oral S-1 (70 mg/m 2 , twice per day) alone on days 1-14 and days [29][30][31][32][33][34][35][36][37][38][39][40][41][42].…”
Section: Treatments and Assessmentsmentioning
confidence: 99%
“…Three or four weeks after completion of CCRT, two additional cycles of consolidation chemotherapy (docetaxel 75mg/m 2 on day 1 and cisplatin 25mg/m 2 on days 1-3) were performed at 3-or 4-weeks intervals. (b) Patients were administered oral S-1 (70 mg/m 2 , twice per day) alone on days 1-14 and days [29][30][31][32][33][34][35][36][37][38][39][40][41][42].…”
Section: Treatments and Assessmentsmentioning
confidence: 99%
“…Radiation-related lymphopenia (RRL) affects clinical outcomes of patients with various cancers (10), most of which are aggressive or at an advanced stage, including glioblastoma, small cell lung cancer, and locally advanced pancreatic cancer. However, the association between RRL and clinical outcomes of EBC patients remains unexplored, likely owing to the unpredictable influence of various chemotherapy (CTx) regimens, dosages, and individual RT fields on the reduction in absolute lymphocyte counts (ALCs) (11).…”
mentioning
confidence: 99%
“…Lower numbers of circulating lymphocytes after RT were associated with oncogenic immunosuppression and worse survival outcomes in patients with various solid tumors. [18][19][20] Therefore, elevated post-SBRT inflammatory markers, which can reflect a decline in lymphocyte numbers, may be indicative of the complex factors contributing to patient survival and the immunologic response of liver tumors. Currently, there is no consensus on the cutoff value of post-treatment PLR and NLR for poor prognosis, and various methods including the receiver operating characteristics curve (ROC) and median values have been used to determine the optimal segregation points.…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that patients receiving RT may experience a marked decline or even depletion of circulating lymphocytes, 16,17 and a decreased lymphocyte count can be connected to a weaker anti-tumor immune response and an inferior prognosis. [18][19][20] It is therefore of great clinical significance to investigate the predictive roles of the NLR and PLR both before and after SBRT in patients with sHCC.…”
Section: Introductionmentioning
confidence: 99%