A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

You, Longtai; Yang, Chenlu; Du, Yuanyuan; Wang, Wenping; Sun, Mingyi; Liu, Jing; Ma, Baorui; Pang, Linnuo; Zeng, Yawen; Zhang, Zhiqin; Dong, Xiaoxv; Yin, Xingbin; Ni, Jian

doi:10.3389/fphar.2020.01067

Cited by 70 publications

(46 citation statements)

References 153 publications

(176 reference statements)

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“…The second phenanthridine type alkaloid is matrine, a bioactive ingredient of Sophora flavescens and Sophora tonkinensis , two medicinally used plant species in China and many Eastern countries [ 29 , 30 , 31 ]. The compound was found to possess a variety of pharmacological activities comprising different types of cancer [ 29 , 30 , 31 , 32 ]. Same as lycorine, also matrine was used as natural lead compound, also because it is very stable and shows only a few functional groups; therefore, it can be easily modified [ 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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A literature search on plant natural products with antimyeloma activity until the end of 2020 resulted in 92 compounds with effects on at least one human myeloma cell line. Compounds were divided in different compound classes and both their structure–activity-relationships as well as eventual correlations with the pathways described for Multiple Myeloma were discussed. Each of the major compound classes in this review (alkaloids, phenolics, terpenes) revealed interesting candidates, such as dioncophyllines, a group of naphtylisoquinoline alkaloids, which showed pronounced and selective induction of apoptosis when substituted in position 7 of the isoquinoline moiety. Interestingly, out of the phenolic compound class, two of the most noteworthy constituents belong to the relatively small subclass of xanthones, rendering this group a good starting point for possible further drug development. The class of terpenoids also provides noteworthy constituents, such as the highly oxygenated diterpenoid oridonin, which exhibited antiproliferative effects equal to those of bortezomib on RPMI8226 cells. Moreover, triterpenoids containing a lactone ring and/or quinone-like substructures, e.g., bruceantin, whitaferin A, withanolide F, celastrol, and pristimerin, displayed remarkable activity, with the latter two compounds acting as inhibitors of both NF-κB and proteasome chymotrypsin-like activity.

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Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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“…Matrine is the main bioactive compound in Kushen and has several pharmacological effects (You et al, 2020;Zhang et al, 2020), such as anti-cancer, anti-oxidant, anti-inflammatory properties. With these pharmacological properties, matrine has been widely used in the treatment of several diseases (You et al, 2020;Zhang et al, 2020), such as cancers, myocardial ischemia, rheumatoid arthritis, and Alzheimer's disease. Considering the wide broad spectrum activities of matrine, whether it affects platelet function and thrombus formation remains poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, matrine participates in the reversion of multidrug resistance through regulating the expression of several proteins, such as P-glycoprotein (P-gp), multidrug resistancerelated protein (MRP) (Chai et al, 2010;Zhou et al, 2018). Moreover, matrine has anti-inflammatory effects via regulation of the expression of several inflammatory cytokines (such as TNF-α, IL-1) or signaling (such as NF-κB) or the inflammatory mediators (nitric oxide and matrix metalloproteinases) (You et al, 2020). In this study, we showed that matrine also exerts antiplatelet effect as demonstrated by a significant decrease of platelet aggregation, dense granule release, platelet spreading, and clot retraction after matrine treatment compared to vehicle treatment.…”

Section: Discussionmentioning

confidence: 99%

“…At present, the compound Kushen injection has been used as an adjuvant therapy for the treatment of multiple cancers in clinic (Ma et al, 2016;Wang et al, 2016;Yang et al, 2018;Ao et al, 2019). As the main bioactive compound in Kushen, matrine is a naturally occurring alkaloid and has been demonstrated to possess a wide range of pharmacological effects, such as anti-cancer, anti-oxidant, anti-inflammatory, antibacterial, anti-virus, and anti-fibrotic properties (You et al, 2020;Zhang et al, 2020). Due to these pharmacological properties, the role and effect of matrine has been investigated in several diseases, such as cardiovascular diseases (Yu et al, 2014;Zhang et al, 2021), liver diseases (Gao et al, 2018), autoimmune diseases (Zhao et al, 2011;Kan et al, 2015), or multiple cancers (Liu et al, 2014a).…”

Section: Introductionmentioning

confidence: 99%

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Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production

et al. 2021

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Matrine is a naturally occurring alkaloid and possesses a wide range of pharmacological properties, such as anti-cancer, anti-oxidant, anti-inflammatory effects. However, whether it affects platelet function and thrombosis remains unclear. This study aims to evaluate the effect of matrine on platelet function and thrombus formation. Human platelets were treated with matrine (0–1 mg/ml) for 1 h at 37°C followed by measuring platelet aggregation, granule secretion, receptor expression by flow cytometry, spreading and clot retraction. In addition, matrine (10 mg/kg) was injected intraperitoneally into mice to measure tail bleeding time, arterial and venous thrombus formation. Matrine dose-dependently inhibited platelet aggregation and ATP release in response to either collagen-related peptide (Collagen-related peptide, 0.1 μg/ml) or thrombin (0.04 U/mL) stimulation without altering the expression of P-selectin, glycoprotein Ibα, GPVI, or αIIbβ3. In addition, matrine-treated platelets presented significantly decreased spreading on fibrinogen or collagen and clot retraction along with reduced phosphorylation of c-Src. Moreover, matrine administration significantly impaired the in vivo hemostatic function of platelets, arterial and venous thrombus formation. Furthermore, in platelets stimulated with CRP or thrombin, matrine significantly reduced Reactive oxygen species generation, inhibited the phosphorylation level of ERK1/2 (Thr202/Tyr204), p38 (Thr180/Tyr182) and AKT (Thr308/Ser473) as well as increased VASP phosphorylation (Ser239) and intracellular cGMP level. In conclusion, matrine inhibits platelet function, arterial and venous thrombosis, possibly involving inhibition of ROS generation, suggesting that matrine might be used as an antiplatelet agent for treating thrombotic or cardiovascular diseases.

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“…Ridix Sophorae Flavescentis (Ku Shen), documented in editions of the pharmacopoeia of the People's Republic of China, has had more than 200 compounds isolated and extracted. Modern pharmacological studies have shown that matrine is the most active of these components with multiple pharmacological effects, including anti-tumor, antiviral, and antiinflammation, as well as anti-asthmatic activities (Wang et al, 2015a;You et al, 2020). The main target of matrine's anti-tumor therapeutic effects is to induce autophagic cell death and apoptosis in the cancer cells.…”

Section: The Single Herbs In Modulating Autophagymentioning

confidence: 99%

Autophagy Modulators From Chinese Herbal Medicines: Mechanisms and Therapeutic Potentials for Asthma

Zhang

Wang

et al. 2021

Front. Pharmacol.

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Asthma has become a global health issue, suffering more than 300 million people in the world, which is a heterogeneous disease, usually characterized by chronic airway inflammation and airway hyperreactivity. Combination of inhaled corticosteroids (ICS) and long acting β-agonists (LABA) can relieve asthma symptoms and reduce the frequency of exacerbations, especially for patients with refractory asthma, but there are limited treatment options for people who do not gain control on combination ICS/LABA. The increase in ICS dose generally provides little additional benefit, and there is an increased risk of side effects. Therefore, therapeutic interventions integrating the use of different agents that focus on different targets are needed to overcome this set of diseases. Some findings suggest autophagy is closely correlated with the severity of asthma through eosinophilic inflammation, and its modulation may provide novel therapeutic approaches for severe allergic asthma. The chinese herbal medicine (CHM) have been demonstrated clinically as potent therapeutic interventions for asthma. Moreover some reports have found that the bioactive components isolated from CHM could modulate autophagy, and exhibit potent Anti-inflammatory activity. These findings have implied the potential for CHMs in asthma or allergic inflammation therapy via the modulation of autophagy. In this review, we discuss the basic pathomechanisms underpinning asthma, and the potential role of CHMs in treating asthma with modulating autophagy.

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A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

Cited by 70 publications

References 153 publications

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production

Autophagy Modulators From Chinese Herbal Medicines: Mechanisms and Therapeutic Potentials for Asthma

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