A systematic review of transcranial direct current stimulation effects in attention-deficit/hyperactivity disorder

Cosmo, Camila; DiBiasi, Melany; Lima, Vania; Grecco, Luanda Collange; Muszkat, Mauro; Philip, Noah S.; Sena, Eduardo Pondé de

doi:10.1016/j.jad.2020.06.054

Cited by 18 publications

(11 citation statements)

References 97 publications

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“…Systematic reviews and meta-analyses of tDCS studies in ADHD suggest limited evidence of clinical or cognitive improvement with tDCS ( Brauer et al, 2021 , Cosmo et al, 2020 , Salehinejad et al, 2019 ). However, the majority of studies applied 1–5 tDCS sessions over mainly left dorsolateral prefrontal cortex (DLPFC), and only one study applied 5 sessions over the right inferior frontal cortex (IFC) ( Breitling-Ziegler et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial

Westwood

Bozhilova

Criaud

et al. 2022

IBRO Neuroscience Reports

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Section: Introductionmentioning

confidence: 99%

The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial

Westwood

Bozhilova

Criaud

et al. 2022

IBRO Neuroscience Reports

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“…The stimulation arises by providing a constant weak current through two electrodes (anodal and cathodal) placed over the head, which subsequently leads to modulation of neuronal activity ( Thair et al, 2017 ; Chase et al, 2020 ). It is assumed that tDCS has a positive effect on executive functions, such as working memory, attention and inhibitory control, which are typically impaired in people with ADHD ( Cosmo et al, 2020 ). Also, in patients affected by this disease, tDCS is considered to alleviate symptoms of impulsivity ( Allenby et al, 2018 ).…”

Section: Devices As a Novel Promising Methods Of Adhd Treatmentmentioning

confidence: 99%

Treatment of ADHD: Drugs, psychological therapies, devices, complementary and alternative methods as well as the trends in clinical trials

Nazarova

Соколов

Chubarev³

et al. 2022

Front. Pharmacol.

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Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders having a high influence on social interactions. The number of approved treatments and clinical trials for ADHD have increased markedly during the recent decade. This analytical review provides a quantitative overview of the existing pharmacological and non-pharmacological methods of ADHD treatments investigated in clinical trials during 1999–2021. A total of 695 interventional trials were manually assessed from clinicaltrial.gov with the search term « ADHD», and trial data has been used for analysis. A clear majority of the studies investigated non-pharmacological therapies (∼80%), including many behavioral options, such as social skills training, sleep and physical activity interventions, meditation and hypnotherapy. Devices, complementary and other alternative methods of ADHD treatment are also gaining attention. The pharmacological group accounts for ∼20% of all the studies. The most common drug classes include central nervous system stimulants (e.g., methylphenidate hydrochloride, lisdexamfetamine dimesylate, amphetamine sulfate, mixed amphetamine salts, a combination of dexmethylphenidate hydrochloride and serdexmethylphenidate chloride), selective noradrenaline reuptake inhibitors (atomoxetine, viloxazine), and alpha2 adrenergic receptor agonists (guanfacine hydrochloride, clonidine hydrochloride). Several studies investigated antidepressants (e.g., bupropion hydrochloride, vortioxetine), and atypical antipsychotics (e.g., quetiapine, aripiprazole) but these are yet not approved by the FDA for ADHD treatment. We discuss the quantitative trends in clinical trials and provide an overview of the new drug agents and non-pharmacological therapies, drug targets, and novel treatment options.

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“…tingling). These results suggest that tDCS is a promising remote treatment option for AD/HD, and further studies are needed to optimize tDCS parameters for eliciting larger effects (Cosmo et al, 2020;Leffa et al, 2022).…”

Section: Tes In Ad/hdmentioning

confidence: 96%

Remote neurocognitive interventions for attention-deficit/hyperactivity disorder – opportunities and challenges

Zhang¹,

Johnstone²,

Sauce³

et al. 2022

Preprint

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Improving neurocognitive functions through remote interventions has been a promising approach to developing new treatments for attention-deficit/hyperactivity disorder (AD/HD). Remote neurocognitive interventions may address the shortcomings of the current prevailing pharmacological therapies for AD/HD, e.g., side effects and access barriers. Here we review the current options for remote neurocognitive interventions to reduce AD/HD symptoms, including cognitive training, EEG neurofeedback training, transcranial electrical stimulation, and external cranial nerve stimulation. We begin with an overview of the neurocognitive deficits in AD/HD to identify the targets for developing interventions. The role of neuroplasticity in each intervention is then highlighted, due to its essential role in facilitating neuropsychological adaptations. Following this, each intervention type is discussed in terms of the key details of the intervention protocols, the role of neuroplasticity, and the available evidence. Finally, we offer suggestions for future directions in terms of optimizing the existing intervention protocols and developing novel protocols.

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A systematic review of transcranial direct current stimulation effects in attention-deficit/hyperactivity disorder

Cited by 18 publications

References 97 publications

The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial

The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial

Treatment of ADHD: Drugs, psychological therapies, devices, complementary and alternative methods as well as the trends in clinical trials

Remote neurocognitive interventions for attention-deficit/hyperactivity disorder – opportunities and challenges

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