A Systematic Review of Treatment Strategies Including Future Novel Therapies in Crimean-Congo Hemorrhagic Fever

Kouhpayeh, Hamidreza

doi:10.5812/iji.113427

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Mild or moderate cases are discharged with recommendation to complete the ribavirin course. A supportive therapy such as steroids was also recommended by the physician for mild, moderate, and severe cases [33] .…”

Section: Discussionmentioning

confidence: 99%

Alarming update on incidence of Crimean-Congo hemorrhagic fever in Iraq in 2023

Atwan,

Alhilfi,

Mousa

et al. 2024

IJID Regions

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Section: Discussionmentioning

confidence: 99%

Alarming update on incidence of Crimean-Congo hemorrhagic fever in Iraq in 2023

Atwan,

Alhilfi,

Mousa

et al. 2024

IJID Regions

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“…Intravenous proton pump inhibitors (PPIs) to prevent gastrointestinal bleeding and oral progesterone to prevent or control menstrual bleeding are essential. Among the various strategies used to control CCHF, corticosteroids, intravenous immunoglobulin (IVIG), and plasma exchange are not valid enough (23).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Crimean-Congo Hemorrhagic Fever in Kermanshah (2006 - 2020)

Zamanian

Nouri

Shirvani

et al. 2023

Zahedan J Res Med Sci

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Background: Crimean-Congo hemorrhagic fever (CCHF) is a contagious viral disease that can be transmitted through various means, including tick bites, contact with infected blood and animal tissues in slaughterhouses, and healthcare-related infections. Methods: In this study, we examined the incidence of CCHF and analyzed the demographic and clinical data of 130 patients diagnosed with CCHF in Kermanshah, a city located in western Iran, over a period of 15 years (2006 - 2020). Results: During the study, 19 cases tested positive, 66 were verisimilar, and the remaining cases (31.54%) were considered suspected. Among the positive cases, 15 patients recovered, and four died. Of those infected, 63.16% were males residing in rural areas. Additionally, 78.95% of the infected individuals had contact with domestic livestock, 26.31% had a history of contact with ticks, and 10.53% had contact with raw meat or raw liver. Furthermore, 5.26% had a history of contact with a CCHF patient. Conclusions: The highest prevalence of CCHF was observed among men aged 15 to 30 who lived in rural areas. According to the annual reports of people suffering from CCHF, health authorities should prioritize this disease in their public health programs. Since individuals who come into direct contact with livestock and livestock products are at a high risk of contracting diseases, it is important to educate them.

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“…Additionally, the efficacy of other therapeutic approaches such as steroid injection, immunoglobulin therapy, and mAbs need more definitive evidence. Favipiravir is a very promising antiviral medication for the treatment of CCHF [187].…”

Section: Limitations and Advantages Of Novel Treatment Methods In Cchfvmentioning

confidence: 99%

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Muzammil,

Rayyani,

Abbas Sahib

et al. 2024

Biol Proced Online

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Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, and affects large regions of Asia, Southwestern and Southeastern Europe, and Africa. CCHFV can produce symptoms, including no specific clinical symptoms, mild to severe clinical symptoms, or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), and reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, and cheap technology, including biosensors, must be designed and developed to detect CCHFV. The goal of this article is to offer an overview of modern laboratory tests available as well as other innovative detection methods such as biosensors for CCHFV, as well as the benefits and limits of the assays. Furthermore, confirmed cases of CCHF are managed with symptomatic assistance and general supportive care. This study examined the various treatment modalities, as well as their respective limitations and developments, including immunotherapy and antivirals. Recent biotechnology advancements and the availability of suitable animal models have accelerated the development of CCHF vaccines by a substantial margin. We examined a range of potential vaccines for CCHF in this research, comprising nucleic acid, viral particles, inactivated, and multi-epitope vaccines, as well as the present obstacles and developments in this field. Thus, the purpose of this review is to present a comprehensive summary of the endeavors dedicated to advancing various diagnostic, therapeutic, and preventive strategies for CCHF infection in anticipation of forthcoming hazards. Graphical Abstract

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A Systematic Review of Treatment Strategies Including Future Novel Therapies in Crimean-Congo Hemorrhagic Fever

Cited by 8 publications

References 25 publications

Alarming update on incidence of Crimean-Congo hemorrhagic fever in Iraq in 2023

Alarming update on incidence of Crimean-Congo hemorrhagic fever in Iraq in 2023

Evaluation of Crimean-Congo Hemorrhagic Fever in Kermanshah (2006 - 2020)

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

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