A systematic review of validated assessments methods for head and neck lymphedema

Arends, Coralie R.; Lindhout, Josephine E; Molen, Lisette van der; Wilthagen, Erica A.; Brekel, M.W.M. van den; Stuiver, Martijn M.

doi:10.1007/s00405-023-07841-0

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…Head and neck lymphedema (HNL) is an increasingly recognized contributor to post-HNC functional impairment and occur in up to 90% of HNC survivors [25,26 ▪▪ ,27,28]. Whilst the assessment of head and neck lymphoedema and fibrosis is typically based on physical examination/palpation and use of clinician-rated and patient-reported outcome measures, the reporting of use of radiologic and ultrasonographic measures is increasing – describing promising early work to advance the objective assessment/monitoring of these sequelae following HNC treatment [29 ▪ ,30].…”

Section: Imaging In Lymphoedema and Fibrosismentioning

confidence: 99%

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

Wishart

Ward

Galloway

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of Review Radiological imaging is an essential component of head/neck cancer (HNC) care. Advances in imaging modalities (including CT, PET, MRI and ultrasound) and analysis have enhanced our understanding of tumour characteristics and prognosis. However, the application of these methods to evaluate treatment-related toxicities and functional burden is still emerging. This review showcases recent literature applying advanced imaging and radiomics to the assessment and management of sequelae following chemoradiotherapy for HNC. Recent findings Whilst primarily early-stage/exploratory studies, recent investigations have showcased the feasibility of using radiological imaging, particularly advanced/functional MRI (including diffusion-weighted and dynamic contrast-enhanced MRI), to quantify treatment-induced tissue change in the head/neck musculature, and the clinical manifestation of lymphoedema/fibrosis and dysphagia. Advanced feature analysis and radiomic studies have also begun to give specific focus to the prediction of functional endpoints, including dysphagia, trismus and fibrosis. Summary There is demonstrated potential in the use of novel imaging techniques, to help better understand pathophysiology, and improve assessment and treatment of functional deficits following HNC treatment. As larger studies emerge, technologies continue to progress, and pathways to clinical translation are honed, the application of these methods offers an exciting opportunity to transform clinical practices and improve outcomes for HNC survivors.

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Section: Imaging In Lymphoedema and Fibrosismentioning

confidence: 99%

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

Wishart

Ward

Galloway

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…baseline, T 1 = 6 weeks, T 2 = 12 weeks, T 3 = 6 months, T 4 = 12 monthsDomainClinical assessment T 0Physical functionBody compositionBio-impedance Spectroscopy with the InBody device[34,35] measuring the body composition, with as most important outcome parameters: body mass index (BMI), extracellular water (ECW) ratio, fat free mass, phase angle, and the skeletal muscle index (SMI) to deterconstant measurement to determine the %water content at different local points, with the device MoistureMeterD Compact of Delfin[36,37]. 6 points bilateral in the head and neck area (and 1 point submental) are measured according to the protocol "Lymphscanner/MoistureMeter head and neck area" of C.R [38]. of the Netherlands Cancer Institute (circumference tape measurements at the 3 points in the neck area of the previous protocol [(CTC) Version 3.0[40] …”

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confidence: 99%

EffEx-HN trial: study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life

Aperen

Groef

Devoogdt

et al. 2023

Trials

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Background With over 500,000 annually reported cases worldwide, head and neck cancer (HNC) is the seventh most common type of cancer worldwide. Treatment of HNC with chemoradiotherapy frequently results in serious impairments in physical and psychosocial functioning. Besides, HNC patients typically start their cancer treatment already with poor physical and psychosocial health. It has been shown that a sufficient level of physical activity (PA) before, during, and after cancer treatment is associated with fewer negative treatment-related side effects and a better quality of life (QOL). In order to prevent worsening of functioning and limit the physical impact of the HNC treatment, a comprehensive supervised exercise program (CSEP) may be beneficial during early cancer treatment. However, up to now, the feasibility and effectiveness of such a program are not yet investigated thoroughly in HNC. Therefore, the primary objective of this study is to examine the effectiveness of a CSEP during HNC treatment, in addition to usual supportive care, compared to usual supportive care alone, on health-related QOL up to 1 year post-diagnosis. Secondary objectives entail gathering information on (1) the effectiveness of a CSEP on secondary outcomes such as physical and mental function, activities of daily life, and participation in society and (2) the feasibility, possible barriers, and facilitators for participation in a CSEP during HNC treatment. Methods To investigate the effectiveness of the CSEP, a parallel, open-label randomized controlled trial will be performed. To study the feasibility of the CSEP, a mixed-method study will be performed in a subgroup of participants. HNC patients are eligible if they receive radiotherapy at the Radiation-Oncology department of the University Hospital of Leuven. A 4-size permuted block randomization will be used. The control group receives the current standard of supportive care. The intervention group receives a CSEP, additional to the same usual supportive care. The CSEP consists of a 12-week intensive phase with 3 exercise sessions of 1 h per week, where supervision is gradually reduced after 6 weeks. During the maintenance phase (from week 13), patients exercise at home with monthly tele-consultations with a physiotherapist. The CSEP contains supervised aerobic and resistance training. In both groups, outcomes of interest are evaluated through self-reported questionnaires and clinical assessments, at baseline, 6 weeks, 12 weeks, 6 months, and 12 months post-diagnosis. The primary endpoint is health-related QOL, measured with the EORTC QLQ-C30 at 6 months post-diagnosis. Discussion The study will be conducted in accordance with the Declaration of Helsinki. This protocol has been approved by the ethical committee of the University Hospitals Leuven (s65549). Recruitment started in January 2022. Results will be disseminated via peer-reviewed scientific journals and presentations at congresses. Trial registration Trial Registration: ClinicalTrials.gov Identifier: NCT05256238 Date of registration: February 25, 2022

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Current and Future Implications of Lymphedema Surgery in Head and Neck Reconstruction

Kukreja-Pandey,

Gaxiola-Garcia,

Moheeputh

et al. 2024

Oral and Maxillofacial Surgery Clinics of North America

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A systematic review of validated assessments methods for head and neck lymphedema

Cited by 5 publications

References 44 publications

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

EffEx-HN trial: study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life

Current and Future Implications of Lymphedema Surgery in Head and Neck Reconstruction

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