BackgroundResearch into the transdiagnostic processes underlying multiple mental health problems is promising for making clinical practice and interventions more effective and resource-efficient. In this protocol, we describe a systematic review and meta-analysis that will explore time perspective, defined as an individual’s relative investment of attention on past, present, and future, as a possible transdiagnostic factor that may contribute to issues across wide-ranging domains of mental health. MethodsA systematic review and meta-analysis will be conducted to quantify the associations between mental health issue and specific dimensions of time perspective (past, present, future), respectively. The review will include quantitatively measured associations between time perspective and psychological problems published in a peer-reviewed journal from 1st January 1990 up until 1st March 2021, in the English language. Electronic searches will be conducted in Google Scholar, PubMed, MEDLINE, PsycINFO, and Web of Science, and EMBASE and supplemented by expert consultation and inspection of the reference lists of included papers. Screening, quality assessment and data extraction will be conducted by two reviewers independently, and potential conflicts will be resolved through discussion with a third reviewer. Random-effects meta-analysis will be conducted using the metafor package in R statistical software, and quality assessment will employ The Newcastle-Ottawa Quality Assessment Form for Cohort Studies and for Case-Control Studies. The Quality In Prognosis Studies (QUIPS) will be used to evaluate risk of bias. A narrative synthesis will additionally be used to summarize and interpret the results. DiscussionThe present review will provide the first systematic synthesis exploring the associations between time perspective defined as a multidimensional construct and a broad range of mental health issues. This will help evaluate the extent to which time perspective can be considered a key transdiagnostic factor in mental health and thus a key intervention target for the prevention and treatment of multiple mental health issues simultaneously. With a clearer view of the relations between time perspective and various mental health issues based on a robust synthesis, more focused, effective, and efficient interventions may be delivered. Systematic review registrationPROSPERO CRD42021228869