A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus

Abstract

There is no rigorous evidence that oral vanadium supplementation improves glycaemic control in type 2 diabetes. The routine use of vanadium for this purpose cannot be recommended. A large-scale randomized controlled trial is needed to address this clinical question.

Feline Diabetes Mellitus

“…The effects are similar, regardless of the type of vanadium salts used. Several clinical trials in human diabetics have documented improvement in glycemic control; there is, however, a high incidence of gastrointestinal adverse effects (Smith et al, 2008;Clark et al, 2014). There is very little experience with vanadium supplementation in diabetic cats.…”

Vanadium treatment of type 2 diabetes: A view to the future

“…The 20 mg BEOV daily dose that was chosen for this trial was previously determined to be safe and tolerable in human subjects [14] and is equivalent, on a molar basis, to 12.6 mg vanadyl sulfate. Interestingly enough, it would therefore have been below the cut-off for ''real world dose ranges and a minimum duration for effective supplementation" as delineated in a recent review paper [41]. In the latter opinion paper, only studies of at least 30 mg daily and two months' duration were included.…”

Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

“…In drug research, its therapeutic performance is subjected to further scrutiny. 83,84 As a direct result of our chimerical de novo design, TSAG0101 is proposed as a new lead candidate for its structural simplicity and chemical derivation potential. Our in silico studies led theoretical insight into its pharmacophore pattern and molecular blocking action.…”