A systematic review on anti-Alzheimer's disease activity of prescription Kangen-karyu

Paudel, Pradeep; Park, Chan Hum; Jung, Hyun Ah; Yokozawa, Takako; Choi, Jae Sue

doi:10.5582/ddt.2020.03013

Cited by 8 publications

(7 citation statements)

References 42 publications

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“…Numerous studies have shown that the overgeneration of reactive oxygen species and inactive antioxidant defenses result in the failure in removing free radicals or fixing organ damage that leads to the occurrence of oxidative stress, which is considered as a key role in the pathogenesis of dementias (Mao, 2012). Salviae Miltiorrhizae is a popular Chinese herbal plant that is widely employed in the treatment of nerve system disease including dementia (Paudel et al, 2020). Tanshinone IIA (Tan IIA) is an active compound isolated from Salviae Miltiorrhizae (Kong et al, 2021).…”

Section: Hm Extracts On Oxidative Stressmentioning

confidence: 99%

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Progress in the Mechanism of Autophagy and Traditional Chinese Medicine Herb Involved in Dementia

Tao

et al. 2022

Front. Pharmacol.

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Dementias is a kind of neurodegenerative disease, which occurs among the aging population. Current therapeutic outcome for dementia is limited. The medical use of herbal plant has a rich history in traditional Chinese medicine practice for thousands of years. Herbal medicine (HM) may provide a positive effect for prevention and treatment in dementia. As an alternative treatment to dementia, there has been a growing interest in HM extracts in scientific community as a result of its promising study results, mainly in animal experiment. At the molecular level, HM extracts trigger autophagy and reduce generation of reactive oxygen species (ROS) while inhibiting inflammation and reduce neurotoxicity. Experiments both in vivo and in vitro have identified certain potential of HM extracts and natural products as an important regulator factor in mediating autophagy, which might contribute to the improvement of dementia. This brief review not only summarizes the mechanism of autophagy in dementia but also offers a general understanding of the therapeutic mechanism of HM extracts in treating dementia and evaluates the potential clinical practice of HM in general.

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Section: Hm Extracts On Oxidative Stressmentioning

confidence: 99%

“…Salviae Miltiorrhizae is a popular Chinese herbal plant that is widely employed in the treatment of nerve system disease including dementia ( Paudel et al, 2020 ). Tanshinone IIA (Tan IIA) is an active compound isolated from Salviae Miltiorrhizae ( Kong et al, 2021 ).…”

Section: Hm Extracts On Oxidative Stressmentioning

confidence: 99%

Progress in the Mechanism of Autophagy and Traditional Chinese Medicine Herb Involved in Dementia

Tao

et al. 2022

Front. Pharmacol.

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“…Due to its complexity, the etiology of AD is still uncertain. However, some hypotheses have been proposed regarding the factors that may influence its development. , Despite directly targeting one of the most acceptable hypotheses seems a safe approach, it is known that some obstacles have not yet been overcome, leading to a failure in the search for agents associated with the therapy of this disease or even the discovery of new treatments may require novel approaches, which is quite challenging …”

Section: Introductionmentioning

confidence: 99%

“…However, some hypotheses have been proposed regarding the factors that may influence its development. 4,5 Despite directly targeting one of the most acceptable hypotheses seems a safe approach, 6 it is known that some obstacles have not yet been overcome, leading to a failure in the search for agents associated with the therapy of this disease 7 or even the discovery of new treatments may require novel approaches, which is quite challenging. 8 One of them associates the development of AD to type 2 diabetes mellitus (T2DM), in which the link between these two conditions is protein kinase AMPK, where the progression of T2DM can lead to cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics-Assisted Interaction of Vanadium Complex–AMPK: From Force Field Development to Biological Application for Alzheimer’s Treatment

et al. 2023

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A large part of the world’s population is affected by Alzheimer’s disease (AD) and diabetes mellitus type 2, which cause both social and economic impacts. These two conditions are associated with one protein, AMPK. Studies have shown that vanadium complexes, such as bis(N′,N′-dimethylbiguanidato)-oxovanadium(IV), VO(metf)2·H2O, are potential agents against AD. A crucial step in drug design studies is obtaining information about the structure and interaction of these complexes with the biological targets involved in the process through molecular dynamics (MD) simulations. However, MD simulations depend on the choice of a good force field that could present reliable results. Moreover, general force fields are not efficient for describing the properties of metal complexes, and a VO(metf)2·H2O-specific force field does not yet exist; thus, the proper development of a parameter set is necessary. Furthermore, this investigation is essential and relevant given the importance for both the scientific community and the population that is affected by this neurodegenerative disease. Therefore, the present work aims to develop and validate the AMBER force field parameters for VO(metf)2·H2O since the literature lacks such information on metal complexes and investigate through classical molecular dynamics the interactions made by the complex with the protein. The proposed force field proved to be effective for describing the vanadium complex (VC), supported by different analyses and validations. Moreover, it had a great performance when compared to the general AMBER force field. Beyond that, MD findings provided an in-depth perspective of vanadium complex–protein interactions that should be taken into consideration in future studies.

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“…However, some hypotheses have been proposed regarding the factors that may influence on its development. 4,5 Despite directly targeting one of the most acceptable hypotheses to seems a safe approach, 6 it is known that some obstacles have not yet been overcome, leading to a failure in the search for agents associated with the therapy of this disease 7 or even, the discovery of new treatments may require novel approaches, which is quite challenging. 8 One of them associates the development of AD to type 2 diabetes mellitus (T2DM) in which the link between those two conditions is the protein kinase AMPK, where the progression of T2DM can lead to cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics-Assisted Interaction of Vanadium Complex-AMPK: from the force field development to biological application for Alzheimer's treatment

Tavares

Santos

Cunha

et al. 2022

Preprint

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Large part of the world population is affected by Alzheimer's disease (AD) and diabetes mellitus type 2, which causes both social and economic impacts. These two conditions are associated to one protein, AMPK. Studies have shown that vanadium complexes, such as bis(N',N'-dimethylbiguanidato)-oxovanadium (IV), VO(metf)2·H2O, are potential agents against AD. A crucial step on drug design studies is obtaining information about the structure and interaction of these complexes with the biological targets involved in the process through Molecular Dynamics (MD) simulations. However, MDs depend on the choice of a good force field that could present reliable results. Moreover, general force fields are not efficient for describing the properties of metal complexes, and a VO(metf)2·H2O-specific force field does not yet exist, thus the proper development of a parameter set is necessary. Furthermore, this investigation is essential and relevant given the importance for both the scientific community and the population that is affected by this neurodegenerative disease. Therefore, the present work aims to develop and validate the AMBER force field parameters for VO(metf)2·H2O, since the literature lacks such information on metal complexes, and investigate through classical molecular dynamics the interactions made by the complex with the protein. The proposed force field proved to be effective for describing the vanadium complex (VC), supported by different analysis and validation. Moreover, it had a great performance when compared to general AMBER force field. Beyond that, MD findings provided an in-depth perspective about vanadium complex-protein interactions that should be taken into consideration in future studies.

show abstract

A systematic review on anti-Alzheimer's disease activity of prescription Kangen-karyu

Cited by 8 publications

References 42 publications

Progress in the Mechanism of Autophagy and Traditional Chinese Medicine Herb Involved in Dementia

Progress in the Mechanism of Autophagy and Traditional Chinese Medicine Herb Involved in Dementia

Molecular Dynamics-Assisted Interaction of Vanadium Complex–AMPK: From Force Field Development to Biological Application for Alzheimer’s Treatment

Molecular Dynamics-Assisted Interaction of Vanadium Complex-AMPK: from the force field development to biological application for Alzheimer's treatment

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