A Systematic Review on Natural Antioxidant Properties of Resveratrol

Abstract

Polyphenols, including anthocyanins, flavonoids and stilbenes, which constitute one of the most abundant and ubiquitous groups of plant metabolites, are an integral part of the human diet. Resveratrol (3,5,4'-trihydroxystilbene), a naturally occurring polyphenol produced by some plants as a self-defence agent, has an antifungal activity. Resveratrol has been found in some plants (such as grapevine, pine and peanuts) and is considered to have beneficial effects also on human health. The number of studies on resveratrol greatly increased in PubMed database since 1997, after the anticancer effect of this molecule was first reported. The interest in resveratrol in grape was originally sparked by epidemiological studies indicating an inverse relationship between long-standing moderate consumption of red wine and the risk of coronary heart disease; this effect has been ascribed to resveratrol, which possesses diverse biochemical and physiological properties, including antiplatelet and anti-inflammatory proprieties, and provides a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, resveratrol has been described as an anti-aging compound. The consumption of resveratrol (red wine) together with a Mediterranean diet or a fast-food meal ("McDonald'sMeal") had a positive impact on oxidized (ox-) LDL and on the expression of oxidative and inflammatory genes. Therefore, this review summarized the most important scientific data about healing and preventive potential of resveratrol, acting as cardioprotective, neuroprotective, chemopreventive and antioxidant agent.

Grapevine as a Rich Source of Polyphenolic Compounds

“…CVD is associated with high cholesterol levels in the blood-in particular, low-density lipoproteins (LDL). It is widely accepted that an excessive dietary intake of saturated fats and an unhealthy diet increases cholesterol and LDL levels in the blood [15,110,163] Thus, the research by Renaud et al [12] that the French population suffered a relatively low incidence of coronary heart disease (CHD) despite the high intake of saturated fat, has sparked the interest of many researchers. The so-called "French paradox" was attributed to moderate wine consumption and its polyphenolic compounds.…”

Evidences that polyploidization and hybridization affected resveratrol content in Arachis interspecific hybrids

“…Peanuts are among the few plant species that produce resveratrol (Lanz et al, 1990;Sobolev and Cole, 1999;Arora and Japlan, 2018). This phenolic compound is a potent antioxidant (Frankel et al, 1993) whose healing and preventive potential for many human diseases were described in some recent reviews (Colica et al, 2018;Galiniak et al, 2019). Resveratrol is also a phytoalexin that has been associated with resistance to major peanut diseases (Sobolev et al, 2007).…”

Impact of Climatic Conditions on the Resveratrol Concentration in Blend of Vitis vinifera L. cvs. Barbera and Croatina Grape Wines

“…Subsequently, resveratrol was isolated from several other plants, fruits, and derivatives, from grapes, wines, apples, raspberries, blueberries, pistachios, plums, peanuts, and a multitude of medicinal and edible plant species undergoing response to stress conditions [ 3 ]. Experimental and preclinical studies have shown that resveratrol has several health-promoting properties, including cardioprotective effects, chemo-preventive activity in diverse cancers, and a capacity to extend the lifespan of lower organisms [ 4 , 5 , 6 ].…”