A systematic review on the economic burden of interstitial lung disease and the cost-effectiveness of current therapies

Wong, Alyson W.; Koo, John; Ryerson, Christopher J.; Sadatsafavi, Mohsen; Chen, Wenjia

doi:10.1186/s12890-022-01922-2

Cited by 13 publications

(3 citation statements)

References 57 publications

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“…Direct and indirect costs of ILD, including typical IP, were found to be high globally [16]. Timely diagnosis and effective treatment to prevent relapses can limit the mortality and morbidity of the disease.…”

Section: Ethical and Clinical Implications Of The Hypothesismentioning

confidence: 99%

Ground Glass Opacities: Sign of Caution in Typical Interstitial Pneumonia

Tezcan

Kasman

2023

CAJMHE

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Typical interstitial pneumonia (IP) is mainly the fibrotic form of interstitial lung disease. In some cases with typical IP, a certain amount of ground-glass opacity (GGO) can be detected on high-resolution computed tomography, however, some important issues, such as the co-existence of GGO and typical IP, still require further investigation by biopsy. After the diagnosis of typical IP, anti-fibrosis treatment is usually considered. Here, we hypothesized that GGO in typical IP could be a manifestation of an acute inflammatory attack requiring immunosuppressive therapy or an indicator of ongoing contact with trigger factors that initiate pathological reactions in typical IP.

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Section: Ethical and Clinical Implications Of The Hypothesismentioning

confidence: 99%

Ground Glass Opacities: Sign of Caution in Typical Interstitial Pneumonia

Tezcan

Kasman

2023

CAJMHE

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“…tobacco smoking) and manifest in older adults as accelerated lung aging [3]. As such, both diseases are associated with significant morbidity, mortality, and a high economic burden to our society [4,5]. Therefore, there is an urgent need for disease prevention and improved treatments.…”

Section: Introductionmentioning

confidence: 99%

Computational Deconvolution of Cell Type-Specific Gene Expression in COPD and IPF Lungs Reveals Disease Severity Associations

Ryu,

Yun,

Kim

et al. 2024

Preprint

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Rationale: Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes in the lungs. At present, due to cost and technical limitations, profiling cell types is not practical in large epidemiology cohorts (n>1000). Here, we used computational deconvolution to identify cell types in COPD and IPF lungs whose abundances and cell type-specific gene expression are associated with disease diagnosis and severity. Methods: We analyzed lung tissue RNA-seq data from 1026 subjects (COPD, n=465; IPF, n=213; control, n=348) from the Lung Tissue Research Consortium. We performed RNA-seq deconvolution, querying thirty-eight discrete cell-type varieties in the lungs. We tested whether deconvoluted cell-type abundance and cell type-specific gene expression were associated with disease severity. Results: The abundance score of twenty cell types significantly differed between IPF and control lungs. In IPF subjects, eleven and nine cell types were significantly associated with forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO), respectively. Aberrant basaloid cells, a rare cells found in fibrotic lungs, were associated with worse FVC and DLCO in IPF subjects, indicating that this aberrant epithelial population increased with disease severity. Alveolar type 1 and vascular endothelial (VE) capillary A were decreased in COPD lungs compared to controls. An increase in macrophages and classical monocytes was associated with lower DLCO in IPF and COPD subjects. In both diseases, lower non-classical monocytes and VE capillary A cells were associated with increased disease severity. Alveolar type 2 cells and alveolar macrophages had the highest number of genes with cell type-specific differential expression by disease severity in COPD and IPF. In IPF, genes implicated in the pathogenesis of IPF, such as matrix metallopeptidase 7, growth differentiation factor 15, and eph receptor B2, were associated with disease severity in a cell type-specific manner. Conclusion: Utilization of RNA-seq deconvolution enabled us to pinpoint cell types present in the lungs that are associated with the severity of COPD and IPF. This knowledge offers valuable insight into the alterations within tissues in more advanced illness, ultimately providing a better understanding of the underlying pathological processes that drive disease progression.

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“…In 2019, chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory conditions, were the third leading cause of death globally, resulting in 4.0 million deaths and affecting 454.6 million individuals [ 1 , 2 ]. These diseases also impose a substantial burden on healthcare systems owing to hospitalisations, emergency department visits, and long-term care expenses [ 3 – 6 ]. Furthermore, respiratory infections, including upper and lower respiratory tract infections, contribute to a substantial global burden, with billions of cases and millions of deaths reported annually [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of ambient temperature on respiratory disease: a case-crossover study in Seoul

Lee,

Yoon

2024

Respir Res

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Background Respiratory diseases contribute to global morbidity and mortality, and temperature is a significant factor. We investigated the association between ambient temperature and emergency department (ED) visits for various respiratory diseases in Seoul, South Korea. Methods Using data from the National Emergency Department Information System (2008–2017), we analysed 1,616,644 ED visits for respiratory diseases, categorised according to the Korean Standard Classification of Diseases 7th revision codes (J00-J99). Using a time-stratified case-crossover design and a distributed lag nonlinear model, we investigated the effect of temperature exposure on ED visits for respiratory diseases, calculating the relative risk (RR) for the maximum risk temperature (MaxRT) of both cold and hot extremes compared to the minimum risk temperature (MinRT). Results Cold temperatures (MaxRT: -9.0 °C) resulted in a 2.68-fold increase (RR = 2.68, 95% CI = 2.26–3.14) in ED visits for total respiratory diseases, while hot temperatures (MaxRT: 29.4 °C) led to a 1.26-fold increase (RR = 1.26, 95% CI = 1.11–1.42) compared to the MinRT (24.8 °C). Cold temperatures increased the risk of most respiratory diseases, except interstitial lung disease, whereas hot temperatures increased ED visits for acute upper respiratory infections and influenza. Cold temperatures increased ED visits for all age groups, especially those aged 18–64 (RR = 3.54, 95% CI = 2.90–4.33), while hot temperatures significantly affected those < 18 (RR = 1.45, 95% CI = 1.27–1.66). The risk levels were similar in both males and females, regardless of hot and cold temperatures. Conclusion Our findings underscore the significant impact of both cold and heat exposure on ED visits for respiratory diseases, with varying intensities and risk profiles across different population groups.

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A systematic review on the economic burden of interstitial lung disease and the cost-effectiveness of current therapies

Cited by 13 publications

References 57 publications

Ground Glass Opacities: Sign of Caution in Typical Interstitial Pneumonia

Ground Glass Opacities: Sign of Caution in Typical Interstitial Pneumonia

Computational Deconvolution of Cell Type-Specific Gene Expression in COPD and IPF Lungs Reveals Disease Severity Associations

Impact of ambient temperature on respiratory disease: a case-crossover study in Seoul

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