A systematic review on theRosa canina effect and efficacy profiles

Abstract

Rose hip, rose hip and seed and rose hip seed, all were negatively monographed by the German Commission E due to insufficient evidence of effects and effectiveness. Therefore a comprehensive review of the literature was conducted to summarize the pharmacological and clinical effects of Rosa canina L. to reevaluate its usefulness in traditional medicine. For various preparations of rose hip and rose hip and seed, antioxidative and antiinflammatory effects have been demonstrated. Lipophilic constituents are involved in those mechanisms of action. The proprietary rose hip and seed powder Litozin has been employed successfully in a number of exploratory studies in patients suffering from osteoarthritis, rheumatoid arthritis and low back pain. However, the sizes of the clinical effects for the different indications need to be determined to assure clinical significance. There is also a rationale behind the use of Litozin as part of a hypocaloric diet based on the rose hip probiotic, stool regulating and smooth muscle-relaxing actions, as well as the rose hip seed lipid-lowering, antiobese and antiulcerogenic effects. Further research is needed to clarify the importance of the reported promising experimental effects in clinical use and to characterize the optimum rose hip seed oil preparation for topical use in the treatment of skin diseases.

Antibacterial and Antitumor Activities of Some Wild Fruits Grown in Turkey

“…tadic et al (58) reported the anti-inflammatory, gastroprotective, free-radicalscavenging and antimicrobial activities of ethanolic extracts of hawthorn berries mixture (C. monogyna and C. oxycantha). Dog rose (Rosa canina) has astringent, aperient, stomachic, carminative, diuretic, laxative, ophthalmic, anti-inflammatory and tonic activities (11,12). Fruits have been used in folk medicine in the treatment of colds, influenza, minor infectious diseases, scurvy, diarrhea and gastritis (7,11,22).…”

Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial

“…In Europe and America, rosehip is processed widely into jam and juice, used as a vitamin C supplement, in cosmetics, and as a folklore drug in the form of tisane 4,5. The functional capacities of rosehip includes efficacy on diuresis, as a laxative, and as treatments for gout and rheumatism 6,7. There have also been reports of several effects including antioxidative,8 anticold, and anti-inflammatory actions,9 inhibitory effects on metabolism of arachidonic acid and formation of cyclooxygenase 1, cyclooxygenase 2, and leukotriene B4,10 suppression of inflammation and cancer cell proliferation attributable to anticomplementary effect,11 antibacterial action and suppression of experimental nephrolithiasis,12 melanin production inhibition,13 and antidiarrheal action using a methanol extract of rosehip leaves 14.…”

Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons

“…Rose hip is the pseudofruit of the rose plant. 6 The fruit is rich in antioxidants, such as ascorbic acid, phenolic compounds and carotenoids. It has been used in traditional medicine for almost a century for its high content of ascorbic acid.…”