A Systematic Study on Processing Problems and &lt;em&gt;In vitro&lt;/em&gt; Release of &lt;em&gt;Saraca indica&lt;/em&gt; Caesalpiniaceae Bark Powder Tablets

Singh, Satya Prakash; Patra, Chinam Niranjan; Dinda, Subas Chandra

doi:10.4314/tjpr.v11i3.7

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…5 and Table 3, CFSC starts deforming at the same pressure as that of granules (10 kg/cm 2 ). As the compression pressure increased, both CFSC and granules (WG) showed plastic deformation [29]. The degree of plasticity k was almost equal for both CFSC and granules (WG).…”

Section: Heckel Analysismentioning

confidence: 95%

Design and characterization of aceclofenac and paracetamol spherical crystals and their tableting properties

et al. 2015

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Section: Heckel Analysismentioning

confidence: 95%

Design and characterization of aceclofenac and paracetamol spherical crystals and their tableting properties

et al. 2015

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“…Whereas, lower value of 1/b for SDs (F7-F10) showed that it is less cohesive than CA, PM and SDs by FM (F1-F6). [2829]…”

Section: Resultsmentioning

confidence: 99%

Improvement in Dissolution Rate of Cefuroxime Axetil by using Poloxamer 188 and Neusilin US2

Jammula¹,

Patra²,

Swain³

et al. 2013

Indian J Pharm Sci

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A combination of fusion and surface adsorption techniques was used to enhance the dissolution rate of cefuroxime axetil. Solid dispersions of cefuroxime axetil were prepared by two methods, namely fusion method using poloxamer 188 alone and combination of poloxamer 188 and Neusilin US2 by fusion and surface adsorption method. Solid dispersions were evaluated for solubility, phase solubility, flowability, compressibility, Kawakita analysis, Fourier transform-infrared spectra, differential scanning calorimetry, powder X-ray diffraction study, in vitro drug release, and stability study. Solubility studies showed 12- and 14-fold increase in solubility for solid dispersions by fusion method, and fusion and surface adsorption method, respectively. Phase solubility studies showed negative ΔG0tr values for poloxamer 188 at various concentrations (0, 0.25, 0.5, 0.75 and 1%) indicating spontaneous nature of solubilisation. Fourier transform-infrared spectra and differential scanning calorimetry spectra showed that drug and excipients are compatible with each other. Powder X-ray diffraction study studies indicated that presence of Neusilin US2 is less likely to promote the reversion of the amorphous cefuroxime axetil to crystalline state. in vitro dissolution studies, T50% and mean dissolution time have shown better dissolution rate for solid dispersions by fusion and surface adsorption method. Cefuroxime axetil release at 15 min (Q15) and DE15 exhibited 23- and 20-fold improvement in dissolution rate. The optimized solid dispersion formulation was stable for 6 months of stability study as per ICH guidelines. The stability was ascertained from drug content, in vitro dissolution, Fourier transform-infrared spectra and differential scanning calorimetry study. Hence, this combined approach of fusion and surface adsorption can be used successfully to improve the dissolution rate of poorly soluble biopharmaceutical classification system class II drug cefuroxime axetil.

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In Silico and in Vitro Evaluation of Silk Fibroin Based Amorphous Ball-Milled Binary Solid Dispersion for Improved Solubility, Dissolution and Tablettability: The Case of Naproxen

PANTWALAWALKAR,

NANGARE,

GHAGARE

et al. 2024

Cellulose Chem. Technol.

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The present study aims to use a natural protein silk fibroin (SF) to enhance solubility, dissolution, tablettability, and subsequently, delivery of naproxen (NP) using a green technique  ball milling. The development of SF and NP solid dispersion (SF-NP-SD) for enhancing the solubility, dissolution, and compatibility of NP using ball milling. In silico molecular docking indicated a strong binding affinity of SF towards NP. Herein, SF-NP-SD (1:1) showed significant improvement (p 0.05) in saturation solubility (12 fold) and dissolution (1.46 fold) of NP. Along with reduced wetting time (p 0.05), optimum values of flowability, compressibility, and compatibility were noteworthy. The spectroscopic analysis confirmed favorable interactions, amorphization, and stabilization of NP. The tablet formulation of SF-NP-SD exhibited 1.38-fold enhanced dissolution. Molecular-level hydrophobic and hydrophilic interactions of SF favor molecular-level dispersion, enhance solubility and dissolution, and consecutively, improve drug delivery of NP.

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A Systematic Study on Processing Problems and <em>In vitro</em> Release of <em>Saraca indica</em> Caesalpiniaceae Bark Powder Tablets

Cited by 3 publications

References 14 publications

Design and characterization of aceclofenac and paracetamol spherical crystals and their tableting properties

Design and characterization of aceclofenac and paracetamol spherical crystals and their tableting properties

Improvement in Dissolution Rate of Cefuroxime Axetil by using Poloxamer 188 and Neusilin US2

In Silico and in Vitro Evaluation of Silk Fibroin Based Amorphous Ball-Milled Binary Solid Dispersion for Improved Solubility, Dissolution and Tablettability: The Case of Naproxen

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